The build-up of stock of stable integrated proviruses overtime explains the difficulty in reducing HIV-1 DNA levels when treatment is initiated at the chronic stage of the infection

Autor: Gilbert Mchantaf, Antoine Cheret, Adeline Melard, Asma Essat, Elise Gardiennet, Rebecca Bauer, Caroline Charre, Vincent Meiffredy, Lionel Piroth, Cécile Goujard, Laurence Meyer, Véronique Avettand-Fenoel

Publikováno v: Journal of Virus Eradication, Vol 9, Iss 4, Pp 100357- (2023)

Background: Understanding factors affecting the size and the evolution of the HIV reservoir is essential for the development of curative strategies. This study aimed to assess the impact of antiretroviral therapy (ART) initiated during primary infect

Externí odkaz: https://doaj.org/article/b1252e915fef4f8583db7a4cedaa010f

Association between cellular HIV-1 DNA level and mortality in HIV-1 infected African adults starting ART with high CD4 counts

Autor: Jean Baptiste N'takpe, Delphine Gabillard, Raoul Moh, Elise Gardiennet, Arlette Emieme, Anani Badje, Gérard M. Kouame, Thomas-d'Aquin Toni, Sophie Karcher, Jérome Le Carrou, Hervé Ménan, Christine Danel, Serge P. Eholie, Christine Rouzioux, Xavier Anglaret

Publikováno v: EBioMedicine, Vol 56, Iss , Pp 102815- (2020)

Background: High HIV-1 DNA levels in peripheral blood mononuclear cells (PBMC) were associated with a higher risk of severe morbidity and a faster decline in CD4 count in ART-naive patients. We report the association between HIV-1 DNA and mortality i

Externí odkaz: https://doaj.org/article/bea6b65d892a4824b92df0a06e3ad13d

HIV-1-RNA and total HIV-1-DNA loads in the genital compartment in men receiving dolutegravir- versus darunavir-based combined ART (cART) regimens during primary HIV infection

Autor: Alice-Andrée Mariaggi, Rebecca Bauer, Caroline Charre, Elise Gardiennet, Vincent Meiffredy, Faiza Ajana, Karine Lacombe, Gilles Pialoux, Eric Cua, Christine Rouzioux, Laurence Meyer, Antoine Cheret, Véronique Avettand-Fenoel

Publikováno v: The Journal of antimicrobial chemotherapy. 77(3)

Background Dolutegravir is a widespread integrase strand-transfer inhibitor (INSTI) recommended for treatment of primary HIV infection (PHI). PHI is a high-risk stage for sexual transmission because of the high viral load in semen. Yet dolutegravir c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3556a9ec19e4c68a8b35ef1cb822ba2
https://pubmed.ncbi.nlm.nih.gov/35195692

Performance of 30 commercial SARS-CoV-2 serology assays in testing symptomatic COVID-19 patients

Autor: Agnès Carol, Narjis Boukli, Elyanne Gault, Juliette Villemonteix, Tiffany Guilleminot, Héloïse Petit, Guislaine Carcelain, Dominique Challine, Diane Descamps, Sarah Maylin, Jean-François Meritet, Claire Périllaud-Dubois, Laurence Morand-Joubert, Sonia Burrel, Marie-Anne Rameix-Welti, Frédérique Moreau, Charlotte Charpentier, Jérôme LeGoff, Jean-Michel Pawlotsky, Anne-Geneviève Marcelin, Emmanuel Gordien, Christelle Vauloup-Fellous, Samuel Lepape, Isabelle Podglajen, Slim Fourati, Sepideh Akhavan, Nadhira Houhou-Fidouh, Ana-Maria Roque-Afonso, Marianne Leruez-Ville, Vincent Mackiewicz, Florence Damond, Véronique Avettand-Fenoel, Jacques Fourgeaud, Jean-Baptiste Ronat, Chakib Alloui, Ségolène Brichler, Joël Gozlan, Thierry Naas, Elise Gardiennet, Marie-Laure Chaix, Stéphane Bonacorsi, Constance Delaugerre, Flore Rozenberg, Laurent Dortet, Stéphane Marot

Publikováno v: European Journal of Clinical Microbiology and Infectious Diseases
European Journal of Clinical Microbiology and Infectious Diseases, Springer Verlag, 2021, Online ahead of print. ⟨10.1007/s10096-021-04232-3⟩
European Journal of Clinical Microbiology and Infectious Diseases, 2021, Online ahead of print. ⟨10.1007/s10096-021-04232-3⟩
European Journal of Clinical Microbiology & Infectious Diseases

We report evaluation of 30 assays’ (17 rapid tests (RDTs) and 13 automated/manual ELISA/CLIA assay (IAs)) clinical performances with 2594 sera collected from symptomatic patients with positive SARS-CoV-2 rRT-PCR on a respiratory sample, and 1996 pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9fdf0a9a88a22b8dcce4135cab5b96
https://www.hal.inserm.fr/inserm-03227584

Evaluation of 31 Commercial SARS-CoV-2 Serology Assays

Autor: Florence Damond, Fourati S, Charlotte Charpentier, Tiffany Guilleminot, Carol A, Alloui A, Samuel Le Pape, Baudier Mc, Jacques Fourgeaud, Héloïse Petit, Isabelle Podglajen, A G Marcelin, Marianne Leruez-Ville, Marot Ss, Stéphane Bonacorsi, Sepideh Akhavan, Laurent Dortet, Flore Rozenberg, Mackiewicz, Rona J, Elyanne Gault, Joël Gozlan, Thierry Naas, Gordien N, Fellous Cv, Guislaine Carcelain, François Moreau, Sarah Maylin, Ségolène Brichler, Constance Delaugerre, Laurence Morand-Joubert, Fenoel Va, Juliette Villemonteix, Boukli-Hacene N, Sonia Burrel, Elise Gardiennet, Afonso Ar, Pawlotsky Jm, Dubois C, Dominique Challine, Welti Mr, Jérôme Le Goff, Diane Descamps, Jean-François Meritet, Houhou N

Publikováno v: SSRN Electronic Journal.

Background: The virus responsible of severe acute respiratory syndrome named SARS-CoV-2 and causing the new coronavirus disease (COVID-19) has gone global within three months. The current gold standard technique used to detect SARS-CoV-2 is real-time

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46ca87f1ea12561ab375afe3faf54f3f
https://doi.org/10.2139/ssrn.3696824