Výsledky vyhledávání - "Elise E. Drouin"

Akademický článek

Efficacy and Safety of the Bruton's Tyrosine Kinase Inhibitor Evobrutinib in Systemic Lupus Erythematosus: Results of a Phase II, Randomized, Double‐Blind, Placebo‐Controlled Dose‐Ranging Trial

Autor: Daniel J. Wallace, Thomas Dörner, David S. Pisetsky, Jorge Sanchez‐Guerrero, Anand C. Patel, Dana Parsons‐Rich, Claire Le Bolay, Elise E. Drouin, Amy H. Kao, Hans Guehring, Maria Dall'Era

Publikováno v: ACR Open Rheumatology, Vol 5, Iss 1, Pp 38-48 (2023)

Objective Evobrutinib is a highly selective, orally administered Bruton's tyrosine kinase (BTK) inhibitor. The objective of this phase II, multicenter, randomized, double‐blind, placebo‐controlled trial was to evaluate the efficacy and safety of

Externí odkaz: https://doaj.org/article/fbfb7923863e4170999f2062f9b263dc

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Akademický článek

Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody.

Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0191926 (2018)

CTLA-4 and CD28 exemplify a co-inhibitory and co-stimulatory signaling axis that dynamically sculpts the interaction of antigen-specific T cells with antigen-presenting cells. Anti-CTLA-4 antibodies enhance tumor-specific immunity through a variety o

Externí odkaz: https://doaj.org/article/a2c5e638342c4ecea28b08aa00701413

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Efficacy and Safety of the Bruton's Tyrosine Kinase Inhibitor Evobrutinib in Systemic Lupus Erythematosus: Results of a Phase II, Randomized, Double-Blind, Placebo-Controlled Dose-Ranging Trial

Autor: Daniel J, Wallace, Thomas, Dörner, David S, Pisetsky, Jorge, Sanchez-Guerrero, Anand C, Patel, Dana, Parsons-Rich, Claire, Le Bolay, Elise E, Drouin, Amy H, Kao, Hans, Guehring, Maria, Dall'Era

Publikováno v: ACR open rheumatologyREFERENCES.

Evobrutinib is a highly selective, orally administered Bruton's tyrosine kinase (BTK) inhibitor. The objective of this phase II, multicenter, randomized, double-blind, placebo-controlled trial was to evaluate the efficacy and safety of evobrutinib in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8c914e887bef8a0fc2d37ee1efc59306
https://pubmed.ncbi.nlm.nih.gov/36530019

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Immunogenic HLA-DR-Presented Self-Peptides Identified Directly from Clinical Samples of Synovial Tissue, Synovial Fluid, or Peripheral Blood in Patients with Rheumatoid Arthritis or Lyme Arthritis

Autor: Catherine E. Costello, Yu Huang, Jiyang Zhang, Elise E. Drouin, Chunxiang Yao, Allen C. Steere, Deborah R. Leon, Qi Wang

Publikováno v: Journal of Proteome Research. 16:122-136

HLA-DR-molecules are highly expressed in synovial tissue (ST), the target of the immune response in chronic inflammatory forms of arthritis. Here, we used LC-MS/MS to identify HLA-DR-presented self-peptides in cells taken directly from clinical sampl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea83aef857c5daf936cb66ce888c209
https://doi.org/10.1021/acs.jproteome.6b00386

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Annexin A2 is a target of autoimmune T and B cell responses associated with synovial fibroblast proliferation in patients with antibiotic-refractory Lyme arthritis

Autor: Sheila L. Arvikar, Elise E. Drouin, Annalisa Pianta, Klemen Strle, Jameson T. Crowley, Allen C. Steere, Catherine E. Costello

Publikováno v: Clinical Immunology. 160:336-341

In this study, autoantibody responses to annexin A2 were found in 11-15% of 278 patients with Lyme disease, including in those with erythema migrans (EM), an early sign of the illness, and in those with antibiotic-responsive or antibiotic-refractory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5538e4f39017c2d828ba0babc6c46a
https://doi.org/10.1016/j.clim.2015.07.005

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A Highly Expressed Human Protein, Apolipoprotein B-100, Serves as an Autoantigen in a Subgroup of Patients With Lyme Disease

Autor: Allen C. Steere, Elise E. Drouin, Catherine E. Costello, Klemen Strle, Jameson T. Crowley, Annalisa Pianta, Qi Wang

Publikováno v: Journal of Infectious Diseases. 212:1841-1850

To discover novel autoantigens associated with Lyme arthritis (LA), we identified T-cell epitopes presented in vivo by human leukocyte antigen (HLA)-DR molecules in patients' inflamed synovial tissue or joint fluid and tested each epitope for autorea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01674ed4ab6d80009ecf6f0ffc42107
https://doi.org/10.1093/infdis/jiv310

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Evidence for Immune Relevance of Prevotella copri, a Gut Microbe, in Patients with Rheumatoid Arthritis

Autor: Klemen Strle, Sheila L. Arvikar, Qi Wang, Elise E. Drouin, Allen C. Steere, Catherine E. Costello, Annalisa Pianta

Objective Prevotella copri, an intestinal microbe, may overexpand in stool samples from patients with new-onset rheumatoid arthritis (RA), but it is not yet clear whether the organism has immune relevance in RA pathogenesis. Methods HLA–DR–presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2072b6adfba1ec79ac2f07e94c293010
https://europepmc.org/articles/PMC5406252/

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Antibodies to Endothelial Cell Growth Factor and Obliterative Microvascular Lesions in the Synovium of Patients With Antibiotic-Refractory Lyme Arthritis

Autor: Elise E. Drouin, Diana Londoño, Klemen Strle, John M. Aversa, Diego Cadavid, Gail McHugh, Allen C. Steere

Publikováno v: Arthritis & Rheumatology. 66:2124-2133

Lyme disease in the northeastern United States is caused by the tick-transmitted spirochete, Borrelia burgdorferi (1). The most common late manifestation of the infection is Lyme arthritis, which often affects one or both knees (2). Most patients can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a14920e8bec4bd6afe44ce8ad27bc610
https://doi.org/10.1002/art.38618

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