S186: ACQUIRED RESISTANCE TO BISPECIFIC ANTIBODIES BY GENETIC OR EPIGENETIC INACTIVATION OF THE TARGET IN MULTIPLE MYELOMA

Autor: Jennifer Derrien, Sarah Gastineau, Antoine Frigout, Nils Giordano, Mia Cherkaoui, Victor Gaborit, Elise Douillard, Magali Devic, Florence Magrangeas, Philippe Moreau, Stéphane Minvielle, Cyrille Touzeau, Eric Letouzé

Publikováno v: HemaSphere, Vol 7, p e6417985 (2023)

Externí odkaz: https://doaj.org/article/b191db4228db407fb8af7f36ae52d67b

CARD11 and BCL2A1 Join Forces to Promote Resistance to Ibrutinib/Venetoclax Combination in Lymphoma Patients

Autor: Salomé Decombis, Celine Bellanger, Yannick Le Bris, Delphine Boulet, Jane Jardine, Christelle Dousset, Audrey Ménard, Charlotte Kervoelen, Elise Douillard, Philippe Moreau, Stephane Minvielle, Agnes Moreau-Aubry, Benoit Tessoulin, Nicolas Bidère, Steven Le Gouill, Catherine Pellat-Deceunynck, David Chiron

Publikováno v: Blood. 140:2044-2045

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a30cec62d0edda9fba54d3a6579ea299
https://doi.org/10.1182/blood-2022-157694

Chromatin accessibility combined with enhancer clusters activation mediates heterogeneous response to dexamethasone in myeloma cells

Autor: Loïc Campion, Catherine Guérin-Charbonnel, Stephane Minvielle, Victor Gaborit, Jennifer Derrien, Jérémie Bourdon, P. Moreau, Carl Herrmann, Nathalie Roi, Jonathan Cruard, Elise Douillard, Florence Magrangeas, Magali Devic, Jean-Baptiste Alberge, Frank Westermann

Glucocorticoids (GC) effects occur through binding to the GC receptor (GR) which, once translocated to the nucleus, binds to GC response elements (GREs) to activate or repress target genes. Among GCs, dexamethasone (Dex) is widely used in treatment o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27362dc0d11d485800ff9269e8300ab
https://doi.org/10.1101/2021.09.06.459068

The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability

Autor: Jennifer Derrien, Catherine Guérin-Charbonnel, Victor Gaborit, Loïc Campion, Magali Devic, Elise Douillard, Nathalie Roi, Hervé Avet-Loiseau, Olivier Decaux, Thierry Facon, Jan-Philipp Mallm, Roland Eils, Nikhil C. Munshi, Philippe Moreau, Carl Herrmann, Florence Magrangeas, Stéphane Minvielle

Publikováno v: Genome Medicine
Genome Medicine, BioMed Central, 2021, 13 (1), ⟨10.1186/s13073-021-00938-3⟩
Genome Medicine, 2021, 13 (1), ⟨10.1186/s13073-021-00938-3⟩
Genome Medicine, Vol 13, Iss 1, Pp 1-21 (2021)

Background Cancer evolution depends on epigenetic and genetic diversity. Historically, in multiple myeloma (MM), subclonal diversity and tumor evolution have been investigated mostly from a genetic perspective. Methods Here, we performed an analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e399c09b39facc0962bc2d48b27be406
https://pubmed.ncbi.nlm.nih.gov/34372935