Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Elise Champeil"'
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
The clinically used antitumor agent mitomycin C (MC) alkylates DNA upon reductive activation, forming six covalent DNA adducts in this process. This review focuses on differential biological effects of individual adducts in various mammalian cell cul
Externí odkaz:
https://doaj.org/article/9af043799f2e46e69a54d4fb89e9d34e
Autor:
Manuel M. Paz, Elise Champeil
Publikováno v:
Chemical record (New York, N.Y.).
Mitomycin C, (MC), an antitumor drug used in the clinics, is a DNA alkylating agent. Inert in its native form, MC is reduced to reactive mitosenes in cellulo which undergo nucleophilic attack by DNA bases to form monoadducts as well as interstrand cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b60da2dda2b496d0842d9100ccb660e
https://pubmed.ncbi.nlm.nih.gov/36251922
https://pubmed.ncbi.nlm.nih.gov/36251922
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd7a849946161b36e88322ab3677b843
https://doi.org/10.1096/fasebj.2022.36.s1.r1988
https://doi.org/10.1096/fasebj.2022.36.s1.r1988
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4865632e360191eb53e0176e83d0e646
https://doi.org/10.1096/fasebj.2022.36.s1.r1979
https://doi.org/10.1096/fasebj.2022.36.s1.r1979
Autor:
Marian Romaine, Ana G. Petrovic, Manuel M. Paz, Elise Champeil, Gloria Proni, Rinat R. Abzalimov, Owen Zacarias, William Aguilar
Publikováno v:
Chemistry
Mitomycin C, (MC), an antitumor drug and decarbamoylmitomycin C, (DMC), a derivative of MC lacking the carbamoyl moiety, are DNA alkylating agents which can form DNA interstrand crosslinks (ICLs) between deoxyguanosine residues located on opposing DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e665c3bfa36a60577271895d2f00323f
https://doi.org/10.1002/chem.202002452
https://doi.org/10.1002/chem.202002452
Autor:
Shu-Yuan Cheng, Lissette Delgado-Cruzata, Cristina C. Clement, Owen Zacarias, Marta Concheiro-Guisan, Nicholas Towler, Timothy Snyder, Maggie Zheng, Nickolas Almodovar, Christina Gonzalez, Marian Romaine, Anne-Marie Sapse, Elise Champeil
Publikováno v:
Bioorg Chem
While interstrand crosslinks (ICLs) have been considered as one type of DNA damage in the past, there is mounting evidence suggesting that these highly cytotoxic lesions are processed differently by the cellular machinery depending upon the ICL struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec54592d906abc765353ca4c66c8188
https://pubmed.ncbi.nlm.nih.gov/35349830
https://pubmed.ncbi.nlm.nih.gov/35349830
Publikováno v:
Chemistry
Mitomycin C, (MC), an antitumor drug, is a DNA alkylating agent currently used in the clinics. Inert in its native form, MC is reduced to reactive mitosenes, which undergo nucleophilic attack by guanine or adenine bases in DNA to form monoadducts as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::40cdae7bae4149535cf4f0240609e3e6
https://pubmed.ncbi.nlm.nih.gov/34319608
https://pubmed.ncbi.nlm.nih.gov/34319608
Autor:
Manuel M. Paz, Elise Champeil, Maggie Zheng, William Aguilar, Sergey Tsukanov, Shu-Yuan Cheng, Padmanava Pradhan, Owen Zacarias
Publikováno v:
Chemical Research in Toxicology. 31:762-771
Mitomycin C (MC) is an anticancer agent that alkylates DNA to form monoadducts and interstrand cross-links. Decarbamoylmitomycin C (DMC) is an analogue of MC lacking the carbamate on C10. The major DNA adducts isolated from treatment of culture cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acd11600dae178d963ac44704195ec93
https://doi.org/10.1021/acs.chemrestox.8b00102
https://doi.org/10.1021/acs.chemrestox.8b00102
Autor:
Maggie Zheng, Seokjin Hwang, Timothy Snyder, Jake Aquilina, Gloria Proni, Manuel M. Paz, Padmanava Pradhan, Shu-Yuan Cheng, Elise Champeil
Publikováno v:
Bioorg Chem
Mitomycin C (MC), an anti-cancer drug, and its analog, decarbamoylmitomycin C (DMC), are DNA-alkylating agents. MC is currently used in the clinics and its cytotoxicity is mainly due to its ability to form Interstrand Crosslinks (ICLs) which impede D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbad4431b02bb536644de398ab3feb14
https://europepmc.org/articles/PMC6936608/
https://europepmc.org/articles/PMC6936608/
Publikováno v:
International Journal of Oncology
Mitomycin C (MC), a commonly used anticancer drug, induces DNA damage via DNA alkylation. Decarbamoyl mitomycin C (DMC), another mitomycin lacking the carbamate at C10, generates similar lesions as MC. Interstrand cross-links (ICLs) are believed to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996d42278f01f3f6e826038d42fd8362
https://doi.org/10.3892/ijo.2016.3703
https://doi.org/10.3892/ijo.2016.3703