Zobrazeno 1 - 4 of 4 pro vyhledávání: '"Elise, Balaux"'
1
Exploring the chiral space within the active site of α-thrombin with a constrained mimic of d -Phe-Pro-Arg — design, synthesis, inhibitory activity, and X-ray structure of an enzyme–inhibitor complex
Autor: Djorde Musil, Stephen Hanessian, Ingemar Nilsson, Lise-Lotte Olsson, Elise Balaux
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 10:243-247
An indolizidinone motif with strategically placed substitutents was designed and synthesized as a constrained mimic of d -Phe-Pro-Arg. Low nanomolar inhibition of α-thrombin validates the design elements in this inhibitor which also exhibits a 20-fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a3054a4cab707f447d1b7929629218
https://doi.org/10.1016/s0960-894x(99)00669-1
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3
Novel benzimidazole derivatives as selective CB2 agonists
Autor: Daniel, Pagé, Elise, Balaux, Luc, Boisvert, Ziping, Liu, Claire, Milburn, Maxime, Tremblay, Zhongyong, Wei, Simon, Woo, Xuehong, Luo, Yun-Xing, Cheng, Hua, Yang, Sanjay, Srivastava, Fei, Zhou, William, Brown, Miroslaw, Tomaszewski, Christopher, Walpole, Leila, Hodzic, Stéphane, St-Onge, Claude, Godbout, Dominic, Salois, Kemal, Payza, Keymal, Payza
Publikováno v: Bioorganicmedicinal chemistry letters. 18(13)
The preparation and evaluation of a novel class of CB2 agonists based on a benzimidazole moiety are reported. They showed binding affinities up to 1 nM towards the CB2 receptor with partial to full agonist potencies. They also demonstrated good to ex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b38faeba6c5ce18da2d54a009c6fb34
https://pubmed.ncbi.nlm.nih.gov/18522867
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Plný text Recenzováno Digitální knihovna AV ČR
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