Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Elisavet Vardaka"'
Autor:
Andreas Ouranidis, Anastasia Tsiaxerli, Elisavet Vardaka, Catherine K. Markopoulou, Constantinos K. Zacharis, Ioannis Nicolaou, Dimitris Hatzichristou, Anna-Bettina Haidich, Nikolaos Kostomitsopoulos, Kyriakos Kachrimanis
Publikováno v:
Pharmaceuticals, Vol 14, Iss 4, p 365 (2021)
Sildenafil is a potent selective, reversible inhibitor of phosphodiesterase type 5 (PDE5) approved for the treatment of erectile dysfunction and pulmonary arterial hypertension. Whilst twenty years have passed since its original approval by the US Fo
Externí odkaz:
https://doaj.org/article/b615aef0f09e4a1f80460e4bbe665c0b
Autor:
Andreas Ouranidis, Nikos Gkampelis, Elisavet Vardaka, Anna Karagianni, Dimitrios Tsiptsios, Ioannis Nikolakakis, Kyriakos Kachrimanis
Publikováno v:
Pharmaceutics, Vol 12, Iss 10, p 969 (2020)
Wet media milling, coupled with spay drying, is a commonly proposed formulation strategy for the production and solidification of nanosuspensions in order to overcome the solubility barrier of BCS Class II substances. However, the application of mech
Externí odkaz:
https://doaj.org/article/9b46a461baf24cafbac7663a1044f49d
Autor:
Djordje Medarević, Svetlana Ibrić, Elisavet Vardaka, Miodrag Mitrić, Ioannis Nikolakakis, Kyriakos Kachrimanis
Publikováno v:
Pharmaceutics, Vol 12, Iss 1, p 53 (2020)
Nanocrystal formation for the dissolution enhancement of glimepiride was attempted by wet media milling. Different stabilizers were tested and the obtained nanosuspensions were solidified by spray drying in presence of mannitol, and characterized reg
Externí odkaz:
https://doaj.org/article/d08c69c3a50849ff91dbeb145538cf9d
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 139:291-300
In the present work molecular mobility and intermolecular interactions were evaluated as two distinct mechanisms for amorphous agomelatine (AGM) stabilization in the presence of pyrogenic silica. Specifically, amorphous AGM properties related to mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf65786ff3d89a0de94fb1dd9bfaca7
https://doi.org/10.1016/j.ejpb.2019.04.015
https://doi.org/10.1016/j.ejpb.2019.04.015
Autor:
Elisavet Vardaka, Anna Karagianni, Konstantinos Katopodis, Panagiotis Barmpalexis, Kyriakos Kachrimanis
Publikováno v:
European Journal of Pharmaceutical Sciences. 130:260-268
A realistic molecular description of amorphous drug-polymer-plasticizer matrices, suitable for the preparation of amorphous solid dispersions (ASDs) with the aid of fusion-based techniques, was evaluated. Specifically, the incorporation of two model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736e098ee8a27f04807f74d15d95bae3
https://doi.org/10.1016/j.ejps.2019.02.004
https://doi.org/10.1016/j.ejps.2019.02.004
Autor:
Miodrag Mitrić, Elisavet Vardaka, Djordje Medarević, Svetlana Ibrić, Kyriakos Kachrimanis, Ioannis Nikolakakis
Publikováno v:
Pharmaceutics
Volume 12
Issue 1
Pharmaceutics, Vol 12, Iss 1, p 53 (2020)
Volume 12
Issue 1
Pharmaceutics, Vol 12, Iss 1, p 53 (2020)
Nanocrystal formation for the dissolution enhancement of glimepiride was attempted by wet media milling. Different stabilizers were tested and the obtained nanosuspensions were solidified by spray drying in presence of mannitol, and characterized reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c3e1748dea01f9a54cc4ebea73fdc0
https://vinar.vin.bg.ac.rs/bitstream/id/22062/pharmaceutics-12-00053-v2.pdf
https://vinar.vin.bg.ac.rs/bitstream/id/22062/pharmaceutics-12-00053-v2.pdf
Autor:
Panagiotis Barmpalexis, Elisavet Vardaka, Afroditi Kapourani, Konstantinos Katopodis, Kyriakos Kachrimanis
Publikováno v:
International journal of pharmaceutics. 579
The correlation between glass forming ability (GFA) and several thermophysical or physicochemical properties of APIs with the formation and the physical stability of amorphous solid dispersions (ASDs) was evaluated in the present study. Eight poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbed39f22d4c57922d20cf81a6cb3cbe
https://pubmed.ncbi.nlm.nih.gov/32070762
https://pubmed.ncbi.nlm.nih.gov/32070762
Publikováno v:
European Journal of Pharmaceutical Sciences. 166:105979
Nanocrystal formulations of the BCS class II agomelatine, were developed by wet media milling. The most suitable stabilizer was identified and effects of process and formulation variables on the nanocrystal size and ζ-potential were evaluated employ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e4abd92fef2baa77ca69b7944df5ed
https://doi.org/10.1016/j.ejps.2021.105979
https://doi.org/10.1016/j.ejps.2021.105979
Autor:
Kyriakos Kachrimanis, Afroditi Kapourani, Panagiotis Barmpalexis, Konstantinos Katopodis, Elisavet Vardaka
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 145
The present study evaluates the physical stability and intermolecular interactions of Rivaroxaban (RXB) amorphous solid dispersions (ASDs) in polymeric carriers via thermodynamic modelling and molecular simulations. Specifically, the Flory-Huggins (F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdfcdebcc89537b862a130ee3997acb
https://pubmed.ncbi.nlm.nih.gov/31698042
https://pubmed.ncbi.nlm.nih.gov/31698042
Autor:
Dimitrios Tsiptsios, Kyriakos Kachrimanis, Andreas Ouranidis, Nikos Gkampelis, Anna Karagianni, Ioannis Nikolakakis, Elisavet Vardaka
Publikováno v:
Pharmaceutics
Volume 12
Issue 10
Pharmaceutics, Vol 12, Iss 969, p 969 (2020)
Volume 12
Issue 10
Pharmaceutics, Vol 12, Iss 969, p 969 (2020)
Wet media milling, coupled with spay drying, is a commonly proposed formulation strategy for the production and solidification of nanosuspensions in order to overcome the solubility barrier of BCS Class II substances. However, the application of mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be26936580574b50b88cdc9bf708f74
https://doi.org/10.3390/pharmaceutics12100969
https://doi.org/10.3390/pharmaceutics12100969