Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Elisavet Makou"'
Autor:
Heather Kerr, Andrew P. Herbert, Elisavet Makou, Dariusz Abramczyk, Talat H. Malik, Hannah Lomax-Browne, Yi Yang, Isabel Y. Pappworth, Harriet Denton, Anna Richards, Kevin J. Marchbank, Matthew C. Pickering, Paul N. Barlow
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Recombinant human factor H (hFH) has potential for treating diseases linked to aberrant complement regulation including C3 glomerulopathy (C3G) and dry age-related macular degeneration. Murine FH (mFH), produced in the same host, is useful for pre-cl
Externí odkaz:
https://doaj.org/article/4b16b9f4821f41259babd4128c2016d1
Autor:
Robyn M, Biggs, Elisavet, Makou, Scott, Lauder, Andrew P, Herbert, Paul N, Barlow, Suresh K, Katti
Publikováno v:
Current eye research. 47(7)
GEM103 is a recombinantly produced full-length version of the human complement factor H (CFH) under clinical investigation for treatment of age-related macular degeneration (AMD) in individuals carrying an AMD risk-associated genetic variant ofKey bi
Autor:
John David Parkin, Elisavet Makou, Richard G. Bailey, Georg Hähner, Heather J. Johnston, Paul N. Barlow, Alison N. Hulme
Publikováno v:
The Journal of Biological Chemistry
Makou, E, Bailey, R G, Johnston, H, Parkin, J D, Hulme, A N, Hähner, G & Barlow, P N 2019, ' Combining SPR with atomic-force microscopy enables single-molecule insights into activation and suppression of the complement cascade ', Journal of Biological Chemistry, vol. 294, no. 52, pp. 20148-20163 . https://doi.org/10.1074/jbc.RA119.010913
Makou, E, Bailey, R G, Johnston, H, Parkin, J D, Hulme, A N, Hähner, G & Barlow, P N 2019, ' Combining SPR with atomic-force microscopy enables single-molecule insights into activation and suppression of the complement cascade ', Journal of Biological Chemistry, vol. 294, no. 52, pp. 20148-20163 . https://doi.org/10.1074/jbc.RA119.010913
This work was supported by Leverhulme Trust Grant RPG-2015-109. Activation and suppression of the complement system compete on every serum-exposed surface, host or foreign. Potentially harmful outcomes of this competition depend on surface molecules
Autor:
Heather, Kerr, Edwin, Wong, Elisavet, Makou, Yi, Yang, Kevin, Marchbank, David, Kavanagh, Anna, Richards, Andrew P, Herbert, Paul N, Barlow
Publikováno v:
The Journal of Biological Chemistry
Spontaneous activation enables the complement system to respond very rapidly to diverse threats. This activation is efficiently suppressed by complement factor H (CFH) on self-surfaces but not on foreign surfaces. The surface selectivity of CFH, a so
Publikováno v:
Biochemical Society transactions. 43(5)
Complement control protein modules (CCPs) occur in numerous functionally diverse extracellular proteins. Also known as short consensus repeats (SCRs) or sushi domains each CCP contains approximately 60 amino acid residues, including four consensus cy
Publikováno v:
Biochemistry. 52(23)
Factor H (FH) is a soluble regulator of the proteolytic cascade at the core of the evolutionarily ancient vertebrate complement system. Although FH consists of a single chain of similar protein modules, it has a demanding job description. Its chief r
Autor:
Christoph Q. Schmidt, Haydyn D. T. Mertens, Paul N. Barlow, Elisavet Makou, Mateusz Maciejewski, Ilias Matis, Andrew P. Herbert, Dmitri I. Svergun, Dinesh C. Soares
Publikováno v:
Journal of Molecular Biology
Journal of molecular biology 424, 295-312 (2012). doi:10.1016/j.jmb.2012.09.013
Makou, E, Mertens, H D T, Maciejewski, M, Soares, D C, Matis, I, Schmidt, C Q, Herbert, A P, Svergun, D I & Barlow, P N 2012, ' Solution structure of CCP modules 10-12 illuminates functional architecture of the complement regulator, factor H ', Journal of Molecular Biology, vol. 424, no. 5, pp. 295-312 . https://doi.org/10.1016/j.jmb.2012.09.013
Journal of molecular biology 424, 295-312 (2012). doi:10.1016/j.jmb.2012.09.013
Makou, E, Mertens, H D T, Maciejewski, M, Soares, D C, Matis, I, Schmidt, C Q, Herbert, A P, Svergun, D I & Barlow, P N 2012, ' Solution structure of CCP modules 10-12 illuminates functional architecture of the complement regulator, factor H ', Journal of Molecular Biology, vol. 424, no. 5, pp. 295-312 . https://doi.org/10.1016/j.jmb.2012.09.013
The 155-kDa plasma glycoprotein factor H (FH), which consists of 20 complement control protein (CCP) modules, protects self-tissue but not foreign organisms from damage by the complement cascade. Protection is achieved by selective engagement of FH,
Autor:
Arthur J. Rowe, Andrew P. Herbert, Elisavet Makou, Ilias Matis, Dmitry I. Svergun, Paul N. Barlow, Christoph Q. Schmidt, Haydyn D. T. Mertens
Publikováno v:
Molecular Immunology. 46:2866-2867