Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Elisabetta Sporeno"'
Autor:
Elena Fattori, Agostino Cirillo, Manuela Cappelletti, R Cortese, Andrew J. Bett, Alfredo Nicosia, Stefano Colloca, Annalisa Meola, Elisabetta Sporeno, Immacolata Zampaglione, Bruno Bruni Ercole, Mirko Arcuri, Antonella Folgori
Publikováno v:
Gene Therapy. 13:1088-1096
Efficient vaccination against viral agents requires a strong T-cell-mediated immune response to clear viral-infected cells. Optimal vaccination can be achieved by administration of recombinant viral vectors encoding phatogen antigens. Adenoviral vect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b4fff0389003bde150b22467bea1e54
https://doi.org/10.1038/sj.gt.3302754
https://doi.org/10.1038/sj.gt.3302754
Autor:
Monica Cimino, Gennaro Ciliberto, Elisabetta Sporeno, Cira Daniela Rinaudo, Carlo Toniatti, Stefania Lamartina, Giuseppe Roscilli
Publikováno v:
Molecular Therapy. 6:653-663
Diseases requiring frequent and lifelong injections of recombinant proteins would be more efficaciously treated by intramuscular delivery of genes encoding secretable proteins. However, the success of this approach largely depends on our capability t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51195eecaaf22d5a422fb17be3871a0d
https://doi.org/10.1006/mthe.2002.0717
https://doi.org/10.1006/mthe.2002.0717
Autor:
Elisabetta Sporeno, Carlo Toniatti, Wolfgang Hillen, Hermann Bujard, Cira Daniela Rinaudo, Riccardo Cortese, Stefania Lamartina, Gennaro Ciliberto, Giuseppe Roscilli, Luisa Silvi
Publikováno v:
Human Gene Therapy. 13:199-210
The tetracycline (Tet)-dependent regulatory system has been widely used for controlling gene expression. The Tet-on version of the system, in which the reverse Tet-responsive transcriptional activator (rtTA) is positively regulated by Tet or its anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da9d91799d5fdf84733669913bcf9c3
https://doi.org/10.1089/10430340252769734
https://doi.org/10.1089/10430340252769734
Autor:
Elisabetta Sporeno, Gennaro Ciliberto, Armin Lahm, Carlo Toniatti, Ren Xiao Sun, Laura Ciapponi, Giacomo Paonessa, Kari Pulkki, Bernard Klein, Rocco Savino, Andrea Cabibbo
Publikováno v:
Blood. 87:4510-4519
Interleukin-6 (IL-6) is the major growth factor for myeloma cells and is believed to participate in the pathogenesis of chronic autoimmune diseases and postmenopausal osteoporosis. IL-6 has been recently shown to possess three topologically distinct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::474577b3639108930719af7368ac313d
https://doi.org/10.1182/blood.v87.11.4510.bloodjournal87114510
https://doi.org/10.1182/blood.v87.11.4510.bloodjournal87114510
Autor:
Giacomo Paonessa, Rocco Savino, Gennaro Ciliberto, Elisabetta Sporeno, Sergio Altamura, Andrea Cabibbo, Carlo Toniatti
Publikováno v:
Gene. 167:41-47
Phage display of proteins can be used to study ligand-receptor interaction and for the affinity-maturation of binding sites in polypeptide hormones and/or cytokines. We have expressed human interleukin-6 (hIL-6) on M13 phage in a monovalent fashion a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8db8bfdb6c3e9b3a82793460301003
https://doi.org/10.1016/0378-1119(95)00632-x
https://doi.org/10.1016/0378-1119(95)00632-x
Autor:
Giampaolo Nitti, Pietro Pucci, Gaetano Barbato, Giacomo Paonessa, Elisabetta Sporeno, Rita Graziani
Publikováno v:
Cytokine. 6:255-264
Oncostatin M is a cytokine that acts as a growth regulator on a wide variety of cells and has diverse biological activities including acute phase protein induction, LDL receptor up-regulation and cell-specific gene expression. In order to gather info
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599c36e9865406638c62eca5f7d9b997
https://doi.org/10.1016/1043-4666(94)90021-3
https://doi.org/10.1016/1043-4666(94)90021-3
Autor:
Rita Graziani, Paolo Delmastro, Carlo Toniatti, Elisabetta Sporeno, Gennaro Ciliberto, Anna Laura Salvati, Giacomo Paonessa
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
Oncostatin M (OM) and interleukin 6 (IL-6) are functionally related cytokines, which trigger similar biological responses because they share gp130 as a common signal transducing transmembrane receptor. While IL-6 recruits gp130 only upon binding to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fe59bbcdccbb05642caa25cd9b5dd7
https://doi.org/10.1016/s0021-9258(19)78081-8
https://doi.org/10.1016/s0021-9258(19)78081-8
Autor:
Sergio Altamura, Rocco Savino, Anna Laura Salvati, Giacomo Paonessa, Gennaro Ciliberto, Armin Lahm, Elisabetta Sporeno, Carlo Toniatti, Laura Ciapponi
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
Interleukin-6 (IL-6) drives the sequential assembly of a receptor complex formed by the IL-6 receptor (IL-6R alpha) and the signal transducing subunit, gp130. A model of human IL-6 (hIL-6) was constructed by homology using the structure of bovine gra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f590f6f40c2b6835a1ea5f9877ac09a
https://doi.org/10.1002/j.1460-2075.1994.tb06389.x
https://doi.org/10.1002/j.1460-2075.1994.tb06389.x
Autor:
Gennaro Ciliberto, Francesca Bernassola, Carlo Toniatti, Elisabetta Sporeno, Bernard Klein, Anna Demartis, Laura Ciapponi, Gennaro Melino, Rocco Savino
Publikováno v:
Europe PubMed Central
Interleukin-6 (IL-6) plays a central role in the pathogenesis of multiple myeloma, acting both as a growth and a survival factor for myeloma cells. IL-6 has been recently shown to possess three topologically distinct receptor binding sites: site 1 fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9606a387a0aa8ee4323d3887989c3a81
https://pubmed.ncbi.nlm.nih.gov/21590082
https://pubmed.ncbi.nlm.nih.gov/21590082
Autor:
Lionello Ruggeri, Alessandra Vitelli, Alfredo Nicosia, Armin Lahm, Elena Fattori, Alessandra Luzzago, Stefania Capone, Elisabetta Sporeno, Rosalba Tafi, Antonella Folgori, Stefano Colloca, Monica Pezzanera, Riccardo Cortese, Annalisa Meola, Mirko Arcuri, Bruno Bruni Ercole
Publikováno v:
Nature medicine. 12(2)
Three percent of the world's population is chronically infected with the hepatitis C virus (HCV) and at risk of developing liver cancer. Effective cellular immune responses are deemed essential for spontaneous resolution of acute hepatitis C and long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c556860393eabb19b97dcd53efd7f1ba
https://pubmed.ncbi.nlm.nih.gov/17418169
https://pubmed.ncbi.nlm.nih.gov/17418169