Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Elisabetta Michielon"'
Publikováno v:
Michielon, E, de Gruijl, T D & Gibbs, S 2022, ' From simplicity to complexity in current melanoma models ', Experimental Dermatology, vol. 31, no. 12, pp. 1818-1836 . https://doi.org/10.1111/exd.14675
Despite the recent impressive clinical success of immunotherapy against melanoma, development of primary and adaptive resistance against immune checkpoint inhibitors remains a major issue in a large number of treated patients. This highlights the nee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0b4415b70b31c4eaabce0b81c63225
http://www.scopus.com/inward/record.url?scp=85139196545&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85139196545&partnerID=8YFLogxK
Autor:
Elisabetta Michielon, Marta López González, Dorian A. Stolk, Joeke G. C. Stolwijk, Sanne Roffel, Taco Waaijman, Sinéad M. Lougheed, Tanja D. de Gruijl, Susan Gibbs
Publikováno v:
Cancers, 15(10):2849. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, 15(10):2849, 1-22. MDPI Multidisciplinary Digital Publishing Institute
Michielon, E, López González, M, Stolk, D A, Stolwijk, J G C, Roffel, S, Waaijman, T, Lougheed, S M, de Gruijl, T D & Gibbs, S 2023, ' A Reconstructed Human Melanoma-in-Skin Model to Study Immune Modulatory and Angiogenic Mechanisms Facilitating Initial Melanoma Growth and Invasion ', Cancers, vol. 15, no. 10, 2849, pp. 1-22 . https://doi.org/10.3390/cancers15102849
Cancers; Volume 15; Issue 10; Pages: 2849
Michielon, E, López González, M, Stolk, D A, Stolwijk, J G C, Roffel, S, Waaijman, T, Lougheed, S M, de Gruijl, T D & Gibbs, S 2023, ' A Reconstructed Human Melanoma-in-Skin Model to Study Immune Modulatory and Angiogenic Mechanisms Facilitating Initial Melanoma Growth and Invasion ', Cancers, vol. 15, no. 10, 2849 . https://doi.org/10.3390/cancers15102849
Cancers, 15(10):2849, 1-22. MDPI Multidisciplinary Digital Publishing Institute
Michielon, E, López González, M, Stolk, D A, Stolwijk, J G C, Roffel, S, Waaijman, T, Lougheed, S M, de Gruijl, T D & Gibbs, S 2023, ' A Reconstructed Human Melanoma-in-Skin Model to Study Immune Modulatory and Angiogenic Mechanisms Facilitating Initial Melanoma Growth and Invasion ', Cancers, vol. 15, no. 10, 2849, pp. 1-22 . https://doi.org/10.3390/cancers15102849
Cancers; Volume 15; Issue 10; Pages: 2849
Michielon, E, López González, M, Stolk, D A, Stolwijk, J G C, Roffel, S, Waaijman, T, Lougheed, S M, de Gruijl, T D & Gibbs, S 2023, ' A Reconstructed Human Melanoma-in-Skin Model to Study Immune Modulatory and Angiogenic Mechanisms Facilitating Initial Melanoma Growth and Invasion ', Cancers, vol. 15, no. 10, 2849 . https://doi.org/10.3390/cancers15102849
Invasion, immune modulation, and angiogenesis are crucial in melanoma progression. Studies based on animals or two-dimensional cultures poorly recapitulate the tumor-microenvironmental cross-talk found in humans. This highlights a need for more physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f792d8b54df1e7864047e1c7d788269
https://research.vumc.nl/en/publications/e67dad4e-089b-4065-92db-f7b7ce754045
https://research.vumc.nl/en/publications/e67dad4e-089b-4065-92db-f7b7ce754045
Autor:
Xue D. Manz, Robert Szulcek, Xiaoke Pan, Petr Symersky, Chris Dickhoff, Jisca Majolée, Veerle Kremer, Elisabetta Michielon, Ekaterina S. Jordanova, Teodora Radonic, Irene V. Bijnsdorp, Sander R. Piersma, Thang V. Pham, Connie R. Jimenez, Anton Vonk Noordegraaf, Frances S. de Man, Reinier A. Boon, Jan Voorberg, Peter L. Hordijk, Jurjan Aman, Harm Jan Bogaard
Publikováno v:
American journal of respiratory and critical care medicine, 205(7), 808-818. American Thoracic Society
Manz, X D, Szulcek, R, Pan, X, Symersky, P, Dickhoff, C, Majolee, J, Kremer, V, Michielon, E, Jordanova, E S, Radonic, T, Bijnsdorp, I V, Piersma, S R, Pham, T V, Jimenez, C R, Noordegraaf, A V, de Man, F S, Boon, R A, Voorberg, J, Hordijk, P L, Aman, J & Bogaard, H J 2022, ' Epigenetic Modification of the von Willebrand Factor Promoter Drives Platelet Aggregation on the Pulmonary Endothelium in Chronic Thromboembolic Pulmonary Hypertension ', American Journal of Respiratory and Critical Care Medicine, vol. 205, no. 7, pp. 806-818 . https://doi.org/10.1164/rccm.202109-2075OC
American Journal of Respiratory and Critical Care Medicine, 205(7), 806-818. American Thoracic Society
Manz, X D, Szulcek, R, Pan, X, Symersky, P, Dickhoff, C, Majolee, J, Kremer, V, Michielon, E, Jordanova, E S, Radonic, T, Bijnsdorp, I V, Piersma, S R, Pham, T V, Jimenez, C R, Noordegraaf, A V, de Man, F S, Boon, R A, Voorberg, J, Hordijk, P L, Aman, J & Bogaard, H J 2022, ' Epigenetic Modification of the von Willebrand Factor Promoter Drives Platelet Aggregation on the Pulmonary Endothelium in Chronic Thromboembolic Pulmonary Hypertension ', American Journal of Respiratory and Critical Care Medicine, vol. 205, no. 7, pp. 806-818 . https://doi.org/10.1164/rccm.202109-2075OC
American Journal of Respiratory and Critical Care Medicine, 205(7), 806-818. American Thoracic Society
Rationale: von Willebrand factor (vWF) mediates platelet adhesion during thrombosis. While chronic thromboembolic pulmonary hypertension (CTEPH) is associated with increased plasma levels of vWF, the role of this protein in CTEPH has remained enigmat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e382bcba5e7d072452cae1dd7c7f50
http://www.scopus.com/inward/record.url?scp=85128000994&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85128000994&partnerID=8YFLogxK
Autor:
Tanja D. de Gruijl, Susan Gibbs, Judith L A Burm, Elisabetta Michielon, Ekaterina S. Jordanova, Marta López González, Taco Waaijman
Publikováno v:
Cancer Immunology, Immunotherapy, 69(11), 2319-2331. Springer Science and Business Media Deutschland GmbH
Michielon, E, López González, M, Burm, J L A, Waaijman, T, Jordanova, E S, de Gruijl, T D & Gibbs, S 2020, ' Micro-environmental cross-talk in an organotypic human melanoma-in-skin model directs M2-like monocyte differentiation via IL-10 ', Cancer Immunology, Immunotherapy, vol. 69, no. 11, pp. 2319-2331 . https://doi.org/10.1007/s00262-020-02626-4
Cancer Immunology, Immunotherapy
Michielon, E, López González, M, Burm, J L A, Waaijman, T, Jordanova, E S, de Gruijl, T D & Gibbs, S 2020, ' Micro-environmental cross-talk in an organotypic human melanoma-in-skin model directs M2-like monocyte differentiation via IL-10 ', Cancer Immunology, Immunotherapy, vol. 69, no. 11, pp. 2319-2331 . https://doi.org/10.1007/s00262-020-02626-4
Cancer Immunology, Immunotherapy
Preclinical assessment of novel therapies to fight cancer requires models that reflect the human physiology and immune response. Here, we established an in vitro three-dimensional (3D) reconstructed organotypic human melanoma-in-skin (Mel-RhS) model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb39af4083cbc3e967d27a97862f019c
https://research.vu.nl/en/publications/d4df51cd-2f0e-4a20-8ec6-e0b556e31501
https://research.vu.nl/en/publications/d4df51cd-2f0e-4a20-8ec6-e0b556e31501