Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Elisabetta Brunello"'
Publikováno v:
eLife, Vol 10 (2021)
Time-resolved X-ray diffraction of isolated fast-twitch muscles of mice was used to show how structural changes in the myosin-containing thick filaments contribute to the regulation of muscle contraction, extending the previous focus on regulation by
Externí odkaz:
https://doaj.org/article/f41ef1eeccfb4eef9dd63e3d7248b90b
Autor:
Laura Crespi, Monica Bosco, Naika Scalabrino, Massimo Baravelli, Anna Picozzi, Andrea Rossi, Melania Romano, Daniela Imperiale, Silvana Borghi, Elisabetta Brunello, Claudio Anzà
Publikováno v:
Monaldi Archives for Chest Disease, Vol 72, Iss 3 (2016)
Background. Patients following major cardiac surgery are increasingly elderly and present many comorbidities. For these reasons their post-operative phase is often burdened by several complications requiring a long stay in Critical Care and prolonged
Externí odkaz:
https://doaj.org/article/e9b828414b494d97a94c88024d7ccf14
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Contraction of skeletal muscle is triggered by a transient rise in intracellular calcium concentration leading to a structural change in the actin-containing thin filaments that allows binding of myosin motors from the thick filaments. Most myosin mo
Publikováno v:
The Journal of physiology. 600(17)
Myosin motors in resting muscle are inactivated by folding against the backbone of the myosin filament in an ordered helical array and must be released from that conformation to engage in force generation. Time-resolved X-ray diffraction from single
Autor:
Luca Fusi, Theyencheri Narayanan, Elisabetta Brunello, Malcolm Irving, So-Jin Park-Holohan, Andrea Ghisleni, Jesus G. Ovejero
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
'Proceedings of the National Academy of Sciences of the USA ', vol: 117, pages: 8177-8186 (2020)
Brunello, E, Fusi, L, Ghisleni, A, Holohan, S-J, Garcia Ovejero, J, Narayanan, T & Irving, M 2020, ' Myosin filament-based regulation of the dynamics of contraction in heart muscle ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 14, pp. 8177-8186 . https://doi.org/10.1073/pnas.1920632117
'Proceedings of the National Academy of Sciences of the USA ', vol: 117, pages: 8177-8186 (2020)
Brunello, E, Fusi, L, Ghisleni, A, Holohan, S-J, Garcia Ovejero, J, Narayanan, T & Irving, M 2020, ' Myosin filament-based regulation of the dynamics of contraction in heart muscle ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 14, pp. 8177-8186 . https://doi.org/10.1073/pnas.1920632117
Significance Cardiovascular disease continues to be the leading cause of death worldwide, and is frequently associated with heart failure. Efforts to develop better therapeutics for heart failure have been held back by limited understanding of the no
Autor:
Jesus G. Ovejero, Luca Fusi, So-Jin Park-Holohan, Andrea Ghisleni, Theyencheri Narayanan, Malcolm Irving, Elisabetta Brunello
Publikováno v:
Garcia Ovejero, J, Fusi, L, Holohan, S-J, Ghisleni, A, Narayanan, T, Irving, M & Brunello, E 2022, ' Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation ', Journal of General Physiology, vol. 154, no. 3, e202113029 . https://doi.org/10.1085/jgp.202113029
'Journal of General Physiology ', vol: 154, pages: e202113029-1-e202113029-15 (2022)
'Journal of General Physiology ', vol: 154, pages: e202113029-1-e202113029-15 (2022)
Myosin filament–based regulation supplements actin filament–based regulation to control the strength and speed of contraction in heart muscle. In diastole, myosin motors form a folded helical array that inhibits actin interaction; during contract
Autor:
Vincenzo Lombardi, David Gore, Gabriella Piazzesi, Elisabetta Brunello, Massimo Reconditi, Marco Caremani, Luca Fusi, Malcolm Irving, Thomas C. Irving, Marco Linari
Publikováno v:
'Journal of General Physiology ', vol: 151, pages: 1272-1286 (2019)
The Journal of General Physiology
The Journal of General Physiology
The active force of mammalian skeletal muscle is reduced at low temperatures. Caremani et al. reveal that this is due to the rise of a population of myosin motors captured in a refractory state insensitive to muscle activation.
Myosin motors in
Myosin motors in
Autor:
So-Jin Park-Holohan, Luca Fusi, Thomas Kampourakis, Elisabetta Brunello, Malcolm Irving, Martin Rees
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The efficiency of the heart as a pump depends on an autoregulatory mechanism, the Frank–Starling law of the heart, that potentiates the strength of contraction in response to an increase in ventricular filling. Disruption of this mecha
Autor:
Elisabetta Brunello, Samina Juma, Alexander Alexandrovich, Emma Smith, Malcolm Irving, Luca Fusi
Publikováno v:
Biophysical Journal. 121:36a