Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Elisabetta, Chiarparin"'
Autor:
Thomas G. Hayhow, Beth Williamson, Mandy Lawson, Natalie Cureton, Erin L. Braybrooke, Andrew Campbell, Rodrigo J. Carbajo, Azadeh Cheraghchi-Bashi, Elisabetta Chiarparin, Coura R. Diène, Charlene Fallan, David I. Fisher, Frederick W. Goldberg, Lorna Hopcroft, Philip Hopcroft, Anne Jackson, Jason G. Kettle, Teresa Klinowska, Ulrike Künzel, Gillian Lamont, Hilary J. Lewis, Gareth Maglennon, Scott Martin, Pablo Morentin Gutierrez, Christopher J. Morrow, Myria Nikolaou, J. Willem M. Nissink, Patrick O’Shea, Radoslaw Polanski, Markus Schade, James S. Scott, Aaron Smith, Judith Weber, Joanne Wilson, Bin Yang, Claire Crafter
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Targeting the estrogen receptor alpha (ERα) pathway is validated in the clinic as an effective means to treat ER+ breast cancers. Here we present the development of a VHL-targeting and orally bioavailable proteolysis-targeting chimera (PROT
Externí odkaz:
https://doaj.org/article/ec006f9560824ea494be6041bb1eeb60
Autor:
Alexander N. Kapustin, Paul Davey, David Longmire, Carl Matthews, Emily Linnane, Nitin Rustogi, Maria Stavrou, Paul W. A. Devine, Nicholas J. Bond, Lyndsey Hanson, Silvia Sonzini, Alexey Revenko, A. Robert MacLeod, Sarah Ross, Elisabetta Chiarparin, Sanyogitta Puri
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Kapustin et al. investigate the intracellular trafficking of anti-KRAS antisense oligonucleotides. They show that the oligonucleotide AZD4785 is recycled via late endosomes in extracellular vesicles in both cells with poor and good oligo productive u
Externí odkaz:
https://doaj.org/article/e4d7d13e7cd04080b03cedf4614a86e6
Autor:
Hélène Adihou, Ranganath Gopalakrishnan, Tim Förster, Stéphanie M. Guéret, Raphael Gasper, Stefan Geschwindner, Carmen Carrillo García, Hacer Karatas, Ajaybabu V. Pobbati, Mercedes Vazquez‐Chantada, Paul Davey, Carola M. Wassvik, Jeremy Kah Sheng Pang, Boon Seng Soh, Wanjin Hong, Elisabetta Chiarparin, Dennis Schade, Alleyn T. Plowright, Eric Valeur, Malin Lemurell, Tom N. Grossmann, Herbert Waldmann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Targeting the interaction between transcription factor TEAD and its co-repressor VGL4 is an attractive strategy to chemically modulate Hippo signaling. Here, the authors develop a proteomimetic with stabilized tertiary structure that inhibits the TEA
Externí odkaz:
https://doaj.org/article/34105208594045348e3822ea97b488f7
Autor:
Benjamin Jeffries, Zhong Wang, Robert I. Troup, Anaïs Goupille, Jean-Yves Le Questel, Charlene Fallan, James S. Scott, Elisabetta Chiarparin, Jérôme Graton, Bruno Linclau
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2141-2150 (2020)
A systematic comparison of lipophilicity modulations upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl substituents, at a single carbon atom, is provided using directly comparable, and easily accessible model compounds. In addition, comparis
Externí odkaz:
https://doaj.org/article/5644f5bd717b453ba99d0547aa77d2b0
Autor:
James S. Scott, Darren Stead, Bernard Barlaam, Jason Breed, Rodrigo J. Carbajo, Elisabetta Chiarparin, Natalie Cureton, Paul R. J. Davey, David I. Fisher, Eric T. Gangl, Tyler Grebe, Ryan D. Greenwood, Sudhir Hande, Holia Hatoum-Mokdad, Samantha J. Hughes, Thomas A. Hunt, Tony Johnson, Stefan L. Kavanagh, Teresa C. M. Klinowska, Carrie J. B. Larner, Mandy Lawson, Andrew S. Lister, David Longmire, Stacey Marden, Thomas M. McGuire, Caroline McMillan, Lindsay McMurray, Christopher J. Morrow, J. Willem M. Nissink, Thomas A. Moss, Daniel H. O’Donovan, Radoslaw Polanski, Stephen Stokes, Kumar Thakur, Dawn Trueman, Caroline Truman, Michael J. Tucker, Haixia Wang, Nicky Whalley, Dedong Wu, Ye Wu, Bin Yang, Wenzhan Yang
Publikováno v:
Journal of Medicinal Chemistry. 66:2918-2945
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2ec7d4c4fb73ee3f4aed9c21a77b1bf
https://doi.org/10.1021/acs.jmedchem.2c01964
https://doi.org/10.1021/acs.jmedchem.2c01964
Autor:
Adriana E. Tron, Matthew A. Belmonte, Ammar Adam, Brian M. Aquila, Lawrence H. Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J. Embrey, Eric Gangl, Francis D. Gibbons, Gareth P. Gregory, David Hargreaves, J. Adam Hendricks, Jeffrey W. Johannes, Ricky W. Johnstone, Steven L. Kazmirski, Jason G. Kettle, Michelle L. Lamb, Shannon M. Matulis, Ajay K. Nooka, Martin J. Packer, Bo Peng, Philip B. Rawlins, Daniel W. Robbins, Alwin G. Schuller, Nancy Su, Wenzhan Yang, Qing Ye, Xiaolan Zheng, J. Paul Secrist, Edwin A. Clark, David M. Wilson, Stephen E. Fawell, Alexander W. Hird
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
High expression of Mcl-1 promotes tumorigenesis and resistance to anticancer therapies. Here they report a macrocyclic molecule with high selectivity and affinity for Mcl-1 that exhibits potent anti-tumor effects as single agent and in combination wi
Externí odkaz:
https://doaj.org/article/814ff3ef6b204d84917e2b025f3e1da9
Autor:
David Hargreaves, Rodrigo J. Carbajo, Michael S. Bodnarchuk, Kevin Embrey, Philip B. Rawlins, Martin Packer, Sébastien L. Degorce, Alexander W. Hird, Jeffrey W. Johannes, Elisabetta Chiarparin, Markus Schade
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The structure-based design of small-molecule inhibitors targeting protein–protein interactions (PPIs) remains a huge challenge as the drug must bind typically wide and shallow protein sites. A PPI target of high interest for hematological cancer th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2bffac636430c22137888d848f374ca
https://doi.org/10.1073/pnas.2221967120
https://doi.org/10.1073/pnas.2221967120
Autor:
Lydia I. Dewis, Madhavachary Rudrakshula, Christopher Williams, Elisabetta Chiarparin, Eddie L. Myers, Craig P. Butts, Varinder K. Aggarwal
Publikováno v:
Angewandte Chemie International Edition. 62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0132decec5fe8233177de29b92ca228a
https://doi.org/10.1002/anie.202301209
https://doi.org/10.1002/anie.202301209
Autor:
Craig F. Steven, Manasa Punaha-Ravindra, Martin Lee, William Brownlee, Paul Davey, Elisabetta Chiarparin, Valerie G. Brunton, Alison N. Hulme
Publikováno v:
Visualizing and Quantifying Drug Distribution in Tissue VII.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ef6657d8dab35bc70fd8b749293772f
https://doi.org/10.1117/12.2647240
https://doi.org/10.1117/12.2647240
Autor:
Alan Gerber, Sven Hennig, Rosa Bellavita, Isabel Everard, Thirza van Ramshorst, Elisabetta Chiarparin, Nina Louisa Efrém, Nicholas M Pearce, Paul R. J. Davey, Tom N. Grossmann, Paolo Grieco, Mathias Wendt, Mercedes Vazquez-Chantada
Publikováno v:
Angewandte Chemie (International Ed. in English)
Angewandte Chemie-International Edition, 60(25), 13937-13944. Wiley
Wendt, M, Bellavita, R, Gerber, A, Efrém, N L, van Ramshorst, T, Pearce, N M, Davey, P R J, Everard, I, Vazquez-Chantada, M, Chiarparin, E, Grieco, P, Hennig, S & Grossmann, T N 2021, ' Bicyclic β-Sheet Mimetics that Target the Transcriptional Coactivator β-Catenin and Inhibit Wnt Signaling ', Angewandte Chemie-International Edition, vol. 60, no. 25, pp. 13937-13944 . https://doi.org/10.1002/anie.202102082
Angewandte Chemie-International Edition, 60(25), 13937-13944. John Wiley and Sons Ltd
Angewandte Chemie-International Edition, 60(25), 13937-13944. Wiley
Wendt, M, Bellavita, R, Gerber, A, Efrém, N L, van Ramshorst, T, Pearce, N M, Davey, P R J, Everard, I, Vazquez-Chantada, M, Chiarparin, E, Grieco, P, Hennig, S & Grossmann, T N 2021, ' Bicyclic β-Sheet Mimetics that Target the Transcriptional Coactivator β-Catenin and Inhibit Wnt Signaling ', Angewandte Chemie-International Edition, vol. 60, no. 25, pp. 13937-13944 . https://doi.org/10.1002/anie.202102082
Angewandte Chemie-International Edition, 60(25), 13937-13944. John Wiley and Sons Ltd
Protein complexes are defined by the three‐dimensional structure of participating binding partners. Knowledge about these structures can facilitate the design of peptidomimetics which have been applied for example, as inhibitors of protein–protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6210eeee6d272df71252f5b2989c6227
http://europepmc.org/articles/PMC8252567
http://europepmc.org/articles/PMC8252567