Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Elisabeth Wik"'
Autor:
Silje Kjølle, Kenneth Finne, Even Birkeland, Vandana Ardawatia, Ingeborg Winge, Sura Aziz, Gøril Knutsvik, Elisabeth Wik, Joao A. Paulo, Heidrun Vethe, Dimitrios Kleftogiannis, Lars A. Akslen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Cancers are often associated with hypoxia and metabolic reprogramming, resulting in enhanced tumor progression. Here, we aim to study breast cancer hypoxia responses, focusing on secreted proteins from low-grade (luminal-like) and high-grade
Externí odkaz:
https://doaj.org/article/be78054afd6a4ceaaf336d787ab25c13
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 3, Pp 151-164 (2023)
Abstract CD47 expressed on tumor cells binds to signal regulatory protein alpha on macrophages, initiating inhibition of phagocytosis. We investigated the relationships between tumor expression of CD47 and CD68 macrophage content, subsets of tumor‐
Externí odkaz:
https://doaj.org/article/91b86216cd7f482a880dd6492a71a0b6
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 7, Iss 5, Pp 517-527 (2021)
Abstract The tumor microenvironment plays a critical role in breast cancer progression. Here, we investigated tumor‐infiltrating lymphocytes (TILs) and associations with macrophage numbers, tumor stromal elastosis, vascular invasion, and tumor dete
Externí odkaz:
https://doaj.org/article/6c3f1cfe21f44e44844c1b2a24fbb215
Autor:
Kristi Krüger, Laxmi Silwal-Pandit, Elisabeth Wik, Oddbjørn Straume, Ingunn M. Stefansson, Elin Borgen, Øystein Garred, Bjørn Naume, Olav Engebraaten, Lars A. Akslen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract A subset of breast cancer patients benefits from preoperative bevacizumab and chemotherapy, but validated predictive biomarkers are lacking. Here, we aimed to evaluate tissue-based angiogenesis markers for potential predictive value regardin
Externí odkaz:
https://doaj.org/article/c8a2b3892eea4e2a921d64ce837fe2d4
Autor:
Hilde Ytre‐Hauge Smeland, Cecilie Askeland, Elisabeth Wik, Gøril Knutsvik, Anders Molven, Reidunn J Edelmann, Rolf K Reed, David J Warren, Donald Gullberg, Linda Stuhr, Lars A Akslen
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 6, Iss 1, Pp 69-82 (2020)
Abstract Cancer‐associated fibroblasts are essential modifiers of the tumor microenvironment. The collagen‐binding integrin α11β1 has been proposed to be upregulated in a pro‐tumorigenic subtype of cancer‐associated fibroblasts. Here, we an
Externí odkaz:
https://doaj.org/article/093358f51bed4e48943b4d1cb6b8c992
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-17 (2018)
Abstract Background Towards discovering robust cancer biomarkers, it is imperative to unravel the cellular heterogeneity of patient samples and comprehend the interactions between cancer cells and the various cell types in the tumor microenvironment.
Externí odkaz:
https://doaj.org/article/c7b8622ff723496699bbe147089e20ee
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249767 (2021)
Stromal elastosis is related to good prognosis in breast cancer and fibulin-2 helps to stabilize elastic fibers in basement membranes. Here, we examined the level of perivascular fibulin-2 expression in relation to elastosis content, vascular invasio
Externí odkaz:
https://doaj.org/article/8692018ddc1b430ab80b40b13d0e4152
Autor:
Kristi Krüger, Elisabeth Wik, Gøril Knutsvik, Hawa Nalwoga, Tor A. Klingen, Jarle B. Arnes, Ying Chen, Monica Mannelqvist, Konstantina Dimitrakopoulou, Ingunn M. Stefansson, Even Birkeland, Turid Aas, Nicholas P. Tobin, Inge Jonassen, Jonas Bergh, William D. Foulkes, Lars A. Akslen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract We here examined whether Nestin, by protein and mRNA levels, could be a predictor of BRCA1 related breast cancer, a basal-like phenotype, and aggressive tumours. Immunohistochemical staining of Nestin was done in independent breast cancer ho
Externí odkaz:
https://doaj.org/article/2a8a20fe1d2e4fe7af3fd1ff76db984e
Autor:
Kanthida Kusonmano, Mari K Halle, Elisabeth Wik, Erling A Hoivik, Camilla Krakstad, Karen K Mauland, Ingvild L Tangen, Anna Berg, Henrica M J Werner, Jone Trovik, Anne M Øyan, Karl-Henning Kalland, Inge Jonassen, Helga B Salvesen, Kjell Petersen
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206665 (2018)
We have identified nine highly connected and differentially expressed gene subnetworks between aggressive primary tumors and metastatic lesions in endometrial carcinomas. We implemented a novel pipeline combining gene set and network approaches, whic
Externí odkaz:
https://doaj.org/article/fc3d0ff10436409287a37f73b4818276
Autor:
Johannes Landskron, Sigrid M Kraggerud, Elisabeth Wik, Anne Dørum, Merete Bjørnslett, Espen Melum, Øystein Helland, Line Bjørge, Ragnhild A Lothe, Helga B Salvesen, Kjetil Taskén
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0182030 (2017)
The pan lymphocyte marker CD45 exists in various isoforms arising from alternative splicing of the exons 4, 5 and 6. While naïve T cells express CD45RA translated from an mRNA containing exon 4, exons 4-6 are spliced out to encode the shorter CD45R0
Externí odkaz:
https://doaj.org/article/af94fcdd5ceb473d835ce1cc73c37a2c