End-to-end process of hollow spacecraft structures with high frequency and low mass obtained with in-house structural optimization tool and additive manufacturing

Autor: Alexandru-Mihai CISMILIANU, Camelia Elena MUNTEANU, Ionut-Cosmin ONCESCU, Radu-Petru BIBIRE, Valentin STOENESCU, Mihai Victor PRICOP, Elisabeth REY, Sébastien EYRIGNOUX

Publikováno v: INCAS Bulletin, Vol 9, Iss 3, Pp 13-20 (2017)

In the space sector the most decisive elements are: mass reduction, cost saving and minimum lead time; here, structural optimization and additive layer manufacturing (ALM) fit best. The design must be driven by stiffness, because an important require

Externí odkaz: https://doaj.org/article/bfaae86990e94861aab2249e0639a400

Population pharmacokinetics of oxcarbazepine and its monohydroxy derivative in epileptic children

Autor: Christelle Rodrigues, Vincent Jullien, Olivier Dulac, Gérard Pons, Catherine Chiron, Elisabeth Rey, Emmanuelle Comets

Publikováno v: British Journal of Clinical Pharmacology
British Journal of Clinical Pharmacology, Wiley, 2017, 83 (12), pp.2695-2708. ⟨10.1111/bcp.13392⟩
British Journal of Clinical Pharmacology, 2017, 83 (12), pp.2695-2708. ⟨10.1111/bcp.13392⟩

International audience; AimsOxcarbazepine is an antiepileptic drug with an activity mostly due to its monohydroxy derivative metabolite (MHD). A parent-metabolite population pharmacokinetic model in children was developed to evaluate the consistency

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc6387e108c217607388e5d00a8a9e6
https://doi.org/10.1111/bcp.13392

Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated with Stiripentol, Valproate and Clobazam Combination Therapy

Autor: Stéphanie Chhun, Elisabeth Rey, Sophie Peigné, Christelle Rodrigues, Vincent Jullien, Gérard Pons, Michel Tod, Catherine Chiron

Publikováno v: Clinical pharmacokinetics. 57(6)

The aim of this study was to describe the pharmacokinetics of stiripentol in children with Dravet syndrome and to determine the concentrations of stiripentol achieved in this population for the usual 25 mg/kg twice-daily dose. Thirty-five children wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730276ce5a4aa813510cb31996fe2eaf
https://pubmed.ncbi.nlm.nih.gov/28819726

Population Pharmacokinetics of Tenofovir in HIV-1–Infected Pediatric Patients

Autor: Pierre Frange, Saïk Urien, Jean-Marc Tréluyer, Elisabeth Rey, Frantz Foissac, Sihem Benaboud, Déborah Hirt, Stéphane Blanche, Naïm Bouazza

Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes; Vol 58

Objectives To evaluate the pharmacokinetics of tenofovir in children and the influence of covariates [body weight (BW), age, cotreatments]. The main goal was then to suggest for the first time the dose of tenofovir disoproxil fumarate (TDF) to give i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825faa5763be8a6f485107adb5f568db
https://doi.org/10.1097/qai.0b013e3182302ea8

Topiramate pharmacokinetics in infants and young children: Contribution of population analysis

Autor: Rima Nabbout, Vincent Jullien, Catherine Chiron, Stéphanie Chhun, Elisabeth Rey, Olivier Dulac, Gérard Pons, Marion Bouillon-Pichault

Publikováno v: Epilepsy Research. 93:208-211

Summary Purpose To determine the range of topiramate (TPM) concentrations obtained in children under 4 with the recommended dosage regimen (3–9mg/kg/day) and to compare them to adult target ranges. Methods The population pharmacokinetic model devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd48d6658ad27b04bb7917f8a1fd2550
https://doi.org/10.1016/j.eplepsyres.2010.12.004