Homocysteine induces oxidative stress by uncoupling of no synthase activity through reduction of tetrahydrobiopterin

Autor: Gokce Topal, Elisabeth Millanvoye, Francine Rendu, Jean-Luc Boucher, Marie-Aude Devynck, Annie Brunet, Monique David-Dufilho

Publikováno v: Free Radical Biology and Medicine
Free Radical Biology and Medicine, Elsevier, 2004, 36 (12), pp.1532-1541. ⟨10.1016/j.freeradbiomed.2004.03.019⟩

Hyperhomocysteinemia is a risk factor for cardiovascular diseases that induces endothelial dysfunction. Here, we examine the participation of endothelial NO synthase (eNOS) in the homocysteine-induced alterations of NO/O(2)(-) balance in endothelial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c1a698e0bd671ed91c8e053acd6022
https://doi.org/10.1016/j.freeradbiomed.2004.03.019

Lysophosphatidylcholine and 7-oxocholesterol modulate Ca2+ signals and inhibit the phosphorylation of endothelial NO synthase and cytosolic phospholipase A2

Autor: Gokce Topal, Annie Brunet, Francine Rendu, Elisabeth Millanvoye-Van Brussel, Valérie Deckert, Thuc Do Pham, Monique David-Dufilho

Publikováno v: The Biochemical journal. 380(Pt 2)

The oxidation of plasma LDLs (low-density lipoproteins) is a key event in the pathogenesis of atherosclerosis. LPC (lysophosphatidylcholine) and oxysterols are major lipid constitutents of oxidized LDLs. In particular, 7-oxocholesterol has been found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b473d08f7d8ec5e3a3870315439664
https://pubmed.ncbi.nlm.nih.gov/14992685

Regulation of arachidonic acid release by calcium influx in human endothelial cells

Autor: Lahcen Iouzalen, Marie-Aude Devynck, Thuc Do Pham, Monique David-Dufilho, Elisabeth Millanvoye-Van Brussel

Publikováno v: Journal of vascular research. 36(3)

In response to stimuli, endothelial cells release arachidonic acid, a lipid precursor of various vasoactive substances. We have investigated the relationships between cytosolic Ca2+ movements and arachidonic acid release in human umbilical vein endot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e6bb49d0201b81809eef4467255d6c
https://pubmed.ncbi.nlm.nih.gov/10393510

SKF 96365 inhibits intracellular Ca2+ pumps and raises cytosolic Ca2+ concentration without production of nitric oxide and von Willebrand factor

Autor: Elisabeth Millanvoye-Van Brussel, Frédérique Lantoine, Marie-Gabrielle Pernollet, Monique David-Dufilho, Lahcen Iouzalen, Marie-Aude Devynck

Publikováno v: Cell calcium. 20(6)

The effects of the imidazole compound SK&F 96365 on Ca2+ movements and production of nitric oxide (NO) and von Willebrand factor (vWF) have been investigated in human endothelial cells. Changes in cytosolic Ca2+ concentration ([Ca2+]i) were measured

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00c82b6c5d4271d6b8c1f2d237bb202
https://pubmed.ncbi.nlm.nih.gov/8985595

Growth rate and phospholipase C activity in cardiac and aortic spontaneously hypertensive rat cells

Autor: Philippe Meyer, Elisabeth Millanvoye, Marianne Freyss-Beguin, Jean-Luc Paquet, Maryvonne Baudouin-Legros, Sylvie Durant, Pierre Marche

Publikováno v: Scopus-Elsevier

The cellular proliferation rate and phospholipase C sensitivity have been compared in various cardiovascular cells cultured from spontaneously hypertensive (SHR) and Wistar-Kyoto rats (WKY). Aortic smooth muscle cells from SHR showed an enhanced prol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f45170f52f82108efbd28dde9e59d4e
https://doi.org/10.1097/00004872-198812040-00115