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Autor:
Isabelle Manfroid, Silke Rinkwitz, Joachim Djiotsa, Vincianne Verbruggen, Minaka Ishibashi, Jean Giacomotto, Marianne Voz, Bernard Peers, Elisabeth Manning
Publikováno v:
BMC Developmental Biology; Vol 12
BMC Developmental Biology
BMC Developmental Biology, Vol 12, Iss 1, p 37 (2012)
BMC Developmental Biology
BMC Developmental Biology, Vol 12, Iss 1, p 37 (2012)
Background Genetic studies in mouse have demonstrated the crucial function of PAX4 in pancreatic cell differentiation. This transcription factor specifies β- and δ-cell fate at the expense of α-cell identity by repressing Arx gene expression and e