Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Elisabeth Mahen"'
Autor:
Patricia Spilman, Carl Anthony Blau, S Parker, Michael O. Dorschner, Eric Q. Konnick, Elisabeth Mahen, Rahul Parulkar, Jing Zhu, Julie Gralow, Stephen C. Benz, Kimberly A. Burton, Vijayakrishna K. Gadi, Shahrooz Rabizadeh, Christopher Szeto, Francis M. Senecal, Colin C. Pritchard, Patrick Soon-Shiong, Sibel Blau
Publikováno v:
Cancer Research. 81:PS11-13
Background Metastatic triple negative breast cancer (mTNBC) is an inherently diverse disease and while molecular classification of mTNBC has assisted in treatment decisions, if based on only an initial biopsy, it does not take into account the evolut
Autor:
Kimberly A. Burton, Elisabeth Mahen, Eric Quentin Konnick, Sibel Blau, Michael O. Dorschner, Arturo B. Ramirez, Stephen C. Schmechel, Chaozhong Song, Rahul Parulkar, Stephanie Parker, Francis Mark Senecal, Colin C. Pritchard, Brigham H. Mecham, Christopher Szeto, Patricia Spilman, Jingchun Zhu, Vijayakrishna K. Gadi, Roy Ronen, Jackie Stilwell, Eric Kaldjian, Janusz Dutkowski, Stephen Charles Benz, Shahrooz Rabizadeh, Patrick Soon-Shiong, C. Anthony Blau
Publikováno v:
JCO Precision Oncology.
PURPOSE Patients with metastatic triple-negative breast cancer (mTNBC) have poor outcomes. The Intensive Trial of Omics in Cancer (ITOMIC) sought to determine the feasibility and potential efficacy of informing treatment decisions through multiple bi
Autor:
Abhinav K Jain, Kendra Allton, Michelina Iacovino, Elisabeth Mahen, Robert J Milczarek, Thomas P Zwaka, Michael Kyba, Michelle Craig Barton
Publikováno v:
PLoS Biology, Vol 10, Iss 2, p e1001268 (2012)
Multiple studies show that tumor suppressor p53 is a barrier to dedifferentiation; whether this is strictly due to repression of proliferation remains a subject of debate. Here, we show that p53 plays an active role in promoting differentiation of hu
Externí odkaz:
https://doaj.org/article/95383081643b4342828fa9dca7f7709b
Autor:
C. Anthony Blau, Sibel Blau, Kimberly A. Burton, Francis M. Senecal, Vijayakrishna K. Gadi, S Parker, Gary H. Lyman, Nicole M. Kuderer, Elisabeth Mahen, Josh J. Carlson, David Veenstra
Publikováno v:
JCO Precision Oncology
Purpose Multidimensional molecular analysis of tumor tissue intensively over space and time can provide insight into how cancers evolve and escape treatment. Attitudes of participants in such trials have not been assessed. We explored patient views r
Autor:
C. Anthony Blau, Carol Collins, Wayne Monsky, Nathan D. Price, William Stafford Noble, Michael O. Dorschner, Linda Dhaene, Brigham H. Mecham, Arturo Ramirez, Aime Radenbaugh, Jackie L. Stilwell, Chaozhong Song, Nicole M. Kuderer, Julie R. Gralow, Elisabeth Mahen, Colin C. Pritchard, Carla Grandori, David Haussler, Jeannine S. McCune, Mary Goldman, Frank Senecal, Kimberly A. Burton, Vijayakrishna K. Gadi, Jennifer M. Specht, Eric Kladjian, Sibel Blau, Jingchun Zhu
Publikováno v:
Cancer Research. 75:P4-08
We hypothesize that new insights into how cancers progress and respond to treatment will come from clinical trials that i) extensively characterize the molecular features of a patient’s cancer; ii) use results to predict drug susceptibilities; iii)
Autor:
Julie Mathieu, Jason W. Miklas, Christopher Cavanaugh, Abdiasis M. Hussein, Walter L. Ruzzo, Oliver Fiehn, Megan R. Showalter, Hannele Ruohola-Baker, Chaozhong Song, C. Anthony Blau, Yuliang Wang, Lilyana Margaretha, Elisabeth Mahen, Daniel C. Jones, Carol B. Ware
Publikováno v:
Dev Cell
Regulation of embryonic diapause, dormancy that interrupts the tight connection between developmental stage and time, is still poorly understood. Here, we characterize the transcriptional and metabolite profiles of mouse diapause embryos and identify
Autor:
Sibel Blau, William Stafford Noble, Choli Lee, Donna Prunkard, Michael O. Dorschner, C. Anthony Blau, Jie Liu, John T. Halloran, Chaozhong Song, Jeff A. Bilmes, Vijayakrishna K. Gadi, Jay Shendure, Riza M. Daza, Elisabeth Mahen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
A comprehensive characterization of tumor genetic heterogeneity is critical for understanding how cancers evolve and escape treatment. Although many algorithms have been developed for capturing tumor heterogeneity, they are designed for analyzing eit
Autor:
Elisabeth Mahen, William Stafford Noble, Jingchun Zhu, Michael O. Dorschner, Chaozhong Song, Gadi, Stephen C. Benz, Sibel Blau, Carl Anthony Blau, Stephen C. J. Parker, Jie Liu, Komashko, Stephen C. Schmechel, Zhijun Duan, Shelly Heimfeld, Goldsmith J, Kimberly A. Burton, Johnsen J, Naozumi Hiranuma, Francis M. Senecal, David Haussler, Walter L. Ruzzo, Colin C. Pritchard, Allison S, Sofie R. Salama, Wayne Monsky, LaMadrid-Hermannsfeldt M, Patrick Soon-Shiong, Mary Goldman, Amie Radenbaugh
About 16% of breast cancers fall into a clinically aggressive category designated triple negative (TNBC) due to a lack of ERBB2, estrogen receptor and progesterone receptor expression1-3. The mutational spectrum of TNBC has been characterized as part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4cdd2aebfde8917b2d88759e2ed2e0
https://doi.org/10.1101/085316
https://doi.org/10.1101/085316
Autor:
Lacey E. Dobrolecki, Eric Kaldjian, Jackie L. Stilwell, C. Anthony Blau, Timothy J. Martins, Elisabeth Mahen, Arturo Ramirez, Michael T. Lewis
Publikováno v:
Cancer Research. 77:4816-4816
Background. Enumeration, phenotyping and single cell genomics of circulating tumor cells (CTCs) provide three types of information to guide cancer therapy. In some instances, a fourth type is possible: functional analysis in vitro, or in in vivo pati
Autor:
Jackie L. Stilwell, Kellie Howard, Kimberly Kruse, Christopher K. Ellison, Steve Anderson, Taylor J. Jensen, Michael O. Dorschner, Eric Kaldjian, Marcia Eisenberg, Sibel Blau, Debbie Boles, Arturo Ramirez, Brianna Greenwood, Mathias Ehrich, Elisabeth Mahen, Elliott Swanson, Sharon Austin, Anup Madan, John Pruitt
Publikováno v:
Cancer Research. 77:2757-2757
The ability to characterize molecular features of cancer from liquid biopsies is resulting in the development of innovative health care for patients. Longitudinal changes in the mutational profiles of DNA isolated from liquid biopsies are being used