Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Elisabeth M. Storck"'
Autor:
Cory A. Ocasio, Marc P. Baggelaar, James Sipthorp, Ana Losada de la Lastra, Jana Volarić, Christelle Soudy, Elisabeth M. Storck, Susana A. Palma-Duran, James I. MacRae, Goran Tomic, Lotte Carr, Julian Downward, Ulrike S. Eggert, Edward W. Tate
The 23 human ZDHHCS-acyltransferases catalyze long-chainS-acylation at cysteine residues across an extensive network of hundreds of proteins important for normal physiology or dysregulated in disease. Here we present a technology platform to directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecc9036807dfa9291da193193120d746
https://doi.org/10.1101/2023.04.18.537386
https://doi.org/10.1101/2023.04.18.537386
Autor:
Federico Donà, Cagakan Özbalci, Andrea Paquola, Federica Ferrentino, Stephen J. Terry, Elisabeth M. Storck, Gaoge Wang, Ulrike S. Eggert
Publikováno v:
Journal of the American Chemical Society. 144(39)
Lipids are key constituents of all cells, which express thousands of different lipid species. In most cases, it is not known why cells synthesize such diverse lipidomes, nor what regulates their metabolism. Although it is known that dividing cells sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941cb1fc73587edb31c25e1c6f6f058e
https://pubmed.ncbi.nlm.nih.gov/36136763
https://pubmed.ncbi.nlm.nih.gov/36136763
Publikováno v:
Proteomics
Ozbalci, C, Storck Saha, E M & Eggert, U S 2019, ' RNAi Transfection Results in Lipidome Changes ', Proteomics, vol. 19, no. 13, 1800298 . https://doi.org/10.1002/pmic.201800298
Ozbalci, C, Storck Saha, E M & Eggert, U S 2019, ' RNAi Transfection Results in Lipidome Changes ', Proteomics, vol. 19, no. 13, 1800298 . https://doi.org/10.1002/pmic.201800298
RNAi experiments are ubiquitously used in cell biology and are achieved by transfection of small interfering RNAs (siRNAs) into cells using a transfection reagent. These results in knock‐down of proteins of interest, and the phenotypic consequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1257dead9eb01c793ef47cbf62b5695
https://pubmed.ncbi.nlm.nih.gov/31099980
https://pubmed.ncbi.nlm.nih.gov/31099980
Publikováno v:
Annual review of biochemistry. 87
Cells depend on hugely diverse lipidomes for many functions. The actions and structural integrity of the plasma membrane and most organelles also critically depend on membranes and their lipid components. Despite the biological importance of lipids,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ab3bac0bc23f29b2097266a632ea8c
https://pubmed.ncbi.nlm.nih.gov/29494237
https://pubmed.ncbi.nlm.nih.gov/29494237
Autor:
James A, Clulow, Elisabeth M, Storck, Thomas, Lanyon-Hogg, Karunakaran A, Kalesh, Lyn H, Jones, Edward W, Tate
Publikováno v:
Chemical Communications (Cambridge, England)
Protein targets of sulforaphane identified, and their affinities quantified, through competition-based chemical proteomics in two live breast cancer cell lines.
Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential,
Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::551d68162ef163577dfb3811d6324d45
https://pubmed.ncbi.nlm.nih.gov/28439590
https://pubmed.ncbi.nlm.nih.gov/28439590
Publikováno v:
Vascular Pharmacology. 58:202-210
Rho proteins, best known for their regulatory role in actin dynamics, stimulate a variety of processes important in the control of vascular function, including morphogenesis, migration, cell proliferation and adhesion, cell survival, gene expression,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f328a3652ef854d422bb8d049bb74e89
https://doi.org/10.1016/j.vph.2012.09.004
https://doi.org/10.1016/j.vph.2012.09.004
Autor:
Lucie, Duluc, Blerina, Ahmetaj-Shala, Jane, Mitchell, Vahitha B, Abdul-Salam, Abdul S, Mahomed, Lulwah, Aldabbous, Eduardo, Oliver, Lucio, Iannone, Olivier D, Dubois, Elisabeth M, Storck, Edward W, Tate, Lan, Zhao, Martin R, Wilkins, Beata, Wojciak-Stothard
Publikováno v:
Cardiovascular research. 113(3)
RhoB plays a key role in the pathogenesis of hypoxia-induced pulmonary hypertension. Farnesylated RhoB promotes growth responses in cancer cells and we investigated whether inhibition of protein farnesylation will have a protective effect.The analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b462225d9147f1d8da2cb36de9b662e6
https://pubmed.ncbi.nlm.nih.gov/28395024
https://pubmed.ncbi.nlm.nih.gov/28395024
Autor:
Edward W. Tate, Robert P. Fagan, William P. Heal, Elisabeth M. Storck, Claire Janoir, T. H. Tam Dang, Neil F. Fairweather, Lucia de la Riva
Publikováno v:
ACS Chemical Biology. 5:279-285
Clostridium difficile, a leading cause of hospital-acquired infection, possesses a dense surface layer (S-layer) that mediates host-pathogen interactions. The key structural components of the S-layer result from proteolytic cleavage of a precursor pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60656b28fd3b2c9db71ae703e1bd5d4
https://doi.org/10.1021/cb9002859
https://doi.org/10.1021/cb9002859
Autor:
Lucie Duluc, Blerina Ahmetaj-Shala, Jane Mitchell, Vahitha B Abdul-Salam, Robert Edwards, Lulwah Aldabbous, Lucio Iannone, Olivier D Dubois, Elisabeth M Storck, Edward W Tate, Lan Zhao, Martin Wilkins, Beata Wojciak-Stothard
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35
Study objectives: Small GTPase RhoB contributes to pulmonary vascular remodelling in pulmonary hypertension. Farnesylation of RhoB augments cell proliferation while geranylgeranylation of RhoB is believed to be pro-apoptotic. We hypothesized that far
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69257fac75579ac4d8f6a92b14e91c5e
https://doi.org/10.1161/atvb.35.suppl_1.230
https://doi.org/10.1161/atvb.35.suppl_1.230
Autor:
Edward W, Tate, Karunakaran A, Kalesh, Thomas, Lanyon-Hogg, Elisabeth M, Storck, Emmanuelle, Thinon
Publikováno v:
Current Opinion in Chemical Biology
Highlights • Protein lipidation is an essential modification (PTM) in all forms of life. • Key modifications include acylation, prenylation, cholesterylation and GPI anchors. • Global profiling of this class of PTM is beyond the scope of standa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5cc84e87f0bf2750951771183736bd1
https://pubmed.ncbi.nlm.nih.gov/25461723
https://pubmed.ncbi.nlm.nih.gov/25461723