Zobrazeno 1 - 10 of 34 pro vyhledávání: '"Elisabeth Löwdin"'
1
Human plasma protein levels alter the in vitro antifungal activity of caspofungin: An explanation to the effect in critically ill?
Autor: Olof Breuer, Siri Kurland, Mia Furebring, Elisabeth Löwdin, Thomas Tängdén, Pernilla Lagerbäck, Ayda Shams, Erja Chryssanthou, Jan Sjölin
Publikováno v: MycosesREFERENCES. 65(1)
Background Recent studies have shown low caspofungin concentrations in critically ill patients. In some patients, the therapeutic target, area under the total plasma concentration curve in relation to the minimal inhibition concentration (AUCtot/MIC)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd57dfbf75cb219bd430af12dd3ae91
https://pubmed.ncbi.nlm.nih.gov/34709674
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2
Pharmacokinetics of Caspofungin in Critically Ill Patients in Relation to Liver Dysfunction: Differential Impact of Plasma Albumin and Bilirubin Levels
Autor: Mia Furebring, Siri Kurland, Elisabeth Löwdin, Elisabet I. Nielsen, Jan Sjölin, Erik Eliasson
Publikováno v: Antimicrobial agents and chemotherapy. 63(6)
Caspofungin has a liver-dependent metabolism. Reduction of the dose is recommended based on Child-Pugh (C-P) score. In critically ill patients, drug pharmacokinetics (PK) may be altered. The aim of this study was to investigate the prevalence of abno
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c84eb76cd49697f5d36cbb22f2d88a48
https://pubmed.ncbi.nlm.nih.gov/30962329
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3
Posaconazole in Human Serum: a Greater Pharmacodynamic Effect than Predicted by the Non-Protein-Bound Serum Concentration
Autor: Jan Sjölin, Anders Lignell, Otto Cars, Elisabeth Löwdin, Erja Chryssanthou
Publikováno v: Antimicrobial Agents and Chemotherapy. 55:3099-3104
It is generally accepted that only the unbound fraction of a drug is pharmacologically active. Posaconazole is an antifungal agent with a protein binding of 98 to 99%. Taking into account the degree of protein binding, plasma levels in patients, and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736caead4bd41ee0441b4780ac492847
https://doi.org/10.1128/aac.01671-10
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4
Voriconazole-Induced Inhibition of the Fungicidal Activity of Amphotericin B in Candida Strains with Reduced Susceptibility to Voriconazole: an Effect Not Predicted by the MIC Value Alone
Autor: Dominique Sanglard, Otto Cars, Jan Sjölin, Anders Lignell, Elisabeth Löwdin
Publikováno v: Antimicrobial Agents and Chemotherapy. 55:1629-1637
An antagonistic effect of voriconazole on the fungicidal activity of sequential doses of amphotericin B has previously been demonstrated in Candida albicans strains susceptible to voriconazole. Because treatment failure and the need to switch to othe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265af7b1d8b693eac52d7a166690692f
https://doi.org/10.1128/aac.00791-10
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5
Pharmacodynamic Effects of Telavancin against Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Strains in the Presence of Human Albumin or Serum and in an In Vitro Kinetic Model
Autor: Otto Cars, Elisabeth Löwdin, Inga Odenholt
Publikováno v: Antimicrobial Agents and Chemotherapy. 51:3311-3316
Telavancin is a novel bactericidal lipoglycopeptide with multiple mechanisms of action against gram-positive pathogens. The aim of this study was to describe the dynamics of the antimicrobial effect of telavancin against two strains of Staphylococcus
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f219e59b511e4220d88261c8f1c03138
https://doi.org/10.1128/aac.01470-06
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6
Propensity to release endotoxin after two repeated doses of cefuroxime in an in vitro kinetic model: higher release after the second dose
Autor: Elisabeth Löwdin, Jan Sjölin, Gunilla Goscinski, Eva Tano
Publikováno v: Journal of Antimicrobial Chemotherapy. 60:328-333
To study endotoxin release from two strains of Escherichia coli after exposure to two repeated doses of cefuroxime in an in vitro kinetic model.Cefuroxime in concentrations simulating human pharmacokinetics was added to the bacterial solution with a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9e55a416ddfb165e256bc54abc0505
https://doi.org/10.1093/jac/dkm190
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7
A new in-vitro kinetic model to study the pharmacodynamics of antifungal agents: inhibition of the fungicidal activity of amphotericin B against Candida albicans by voriconazole
Autor: Anders Johansson, Elisabeth Löwdin, Jan Sjölin, Otto Cars, Anders Lignell
Publikováno v: Clinical Microbiology and Infection. 13(6):613-619
The aim of this study was to develop and validate a new in-vitro kinetic model for the combination of two drugs with different half-lives, and to use this model for the study of the pharmacodynamic effects of amphotericin B and voriconazole, alone or
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf0f21aa9133727c9a3f1ed378280673
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8
[Cross allergy between penicillins and other beta lactam antibiotics--the risk is much less than previously thought]
Autor: Thomas, Tängden, Mia, Furebring, Elisabeth, Löwdin, Sonja, Werner
Publikováno v: Lakartidningen. 112
Severe IgE-mediated allergic reactions to penicillins are rare but might be fatal. Because some studies demonstrated a high risk of cross-sensitivity to cephalosporins and carbapenems it has been recommended to avoid these antibiotics in patients wit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee8d7fcacc66af112734809e62dff8a5
https://pubmed.ncbi.nlm.nih.gov/25647104
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9
Pharmacodynamic studies of amoxicillin against Streptococcus pneumoniae: comparison of a new pharmacokinetically enhanced formulation (2000 mg twice daily) with standard dosage regimens
Autor: Elisabeth Löwdin, Inga Odenholt, Otto Cars
Publikováno v: Journal of Antimicrobial Chemotherapy. 54:1062-1066
Objectives: To compare the pharmacodynamic effects of a pharmacokinetically enhanced formulation of amoxicillin 2000 mg twice daily, with amoxicillin 875 mg twice daily, 875 mg three times daily and 500 mg three times daily against Streptococcus pneu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d44d58255af61e3530cfe38a7344a25
https://doi.org/10.1093/jac/dkh484
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10
In vitro studies of the pharmacodynamics of teicoplanin against Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecium
Autor: Elisabeth Löwdin, Inga Odenholt, Otto Cars
Publikováno v: Clinical Microbiology and Infection. 9(9):930-937
Objective To investigate the basic pharmacodynamic properties of teicoplanin in vitro for Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecium. Methods The following experiments were performed: (1) bacterial killing by teicoplan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7547db8f62f396e200f341a37616e34b
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