Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Elisabeth Kurunci-Csacsko"'
Autor:
Khayal Gasimli, Monika Raab, Morva Tahmasbi Rad, Elisabeth Kurunci-Csacsko, Sven Becker, Klaus Strebhardt, Mourad Sanhaji
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10892 (2022)
Ovarian cancer (OC) accounts for approximately 4% of cancer deaths in women worldwide and is the deadliest gynecologic malignancy. High-grade serous ovarian cancer (HGSOC) is the most predominant ovarian cancer, in which BRCA1/2 gene mutation ranges
Externí odkaz:
https://doaj.org/article/79b0de13be434a51be3acf2292c76c27
Autor:
Monika Raab, Mourad Sanhaji, Yves Matthess, Albrecht Hörlin, Ioana Lorenz, Christina Dötsch, Nils Habbe, Oliver Waidmann, Elisabeth Kurunci-Csacsko, Ron Firestein, Sven Becker, Klaus Strebhardt
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The overexpression of Polo-like kinase 1 (Plk1) promotes various cancers in humans; sporadic evidence suggests Plk1 could act as a tumor suppressor but the molecular basis for this effect are unclear. Here the authors show that Plk1 inhibition augmen
Externí odkaz:
https://doaj.org/article/a03432a0fac04ac49c63a7cf0e5451dc
Autor:
Birgit Spänkuch, Isabel Steinhauser, Heidrun Wartlick, Elisabeth Kurunci-Csacsko, Klaus I Strebhardt, Klaus Langer
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 3, Pp 223-234 (2008)
Human serum albumin (HSA) nanoparticles represent a promising tool for targeted drug delivery to tumor cells. The coupling of the antibody trastuzumab to nanoparticles uses the capability of human epidermal growth factor receptor 2 (HER2)-positive ce
Externí odkaz:
https://doaj.org/article/db25bf0fb5b1452e8cdb6acdcca45e4e
Autor:
Sanhaji, Khayal Gasimli, Monika Raab, Morva Tahmasbi Rad, Elisabeth Kurunci-Csacsko, Sven Becker, Klaus Strebhardt, Mourad
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10892
Ovarian cancer (OC) accounts for approximately 4% of cancer deaths in women worldwide and is the deadliest gynecologic malignancy. High-grade serous ovarian cancer (HGSOC) is the most predominant ovarian cancer, in which BRCA1/2 gene mutation ranges
Autor:
Andrea Krämer, Sven Becker, Klaus Strebhardt, Mourad Sanhaji, Elisabeth Kurunci-Csacsko, Monika Raab, Nene F. Kobayashi
Publikováno v:
International Journal of Cancer. 146:1086-1098
Ovarian cancer exhibits the highest mortality rate among gynecological malignancies. Antimitotic agents, such as paclitaxel, are frontline drugs for the treatment of ovarian cancer. They inhibit microtubule dynamics and their efficiency relies on a p
Autor:
Christina Dötsch, Monika Raab, Elisabeth Kurunci-Csacsko, Nils Habbe, Ioana Lorenz, Ron Firestein, Oliver Waidmann, Mourad Sanhaji, Sven Becker, Klaus Strebhardt, Yves Matthess, Albrecht Hörlin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications
The spindle assembly checkpoint (SAC) acts as a molecular safeguard in ensuring faithful chromosome transmission during mitosis, which is regulated by a complex interplay between phosphatases and kinases including PLK1. Adenomatous polyposis coli (AP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf3471ac557426d2727f0366746e1a8
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46573
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46573
Autor:
Krishna Saxena, Monika Raab, Santosh Lakshmi Gande, Sridhar Sreeramulu, Elisabeth Kurunci-Csacsko, Susan Klaeger, Denis Kudlinzki, Christina Dötsch, Andrej Scharow, Bernhard Kuster, Harald Schwalbe, Klaus Strebhardt, Thorsten Berg
Publikováno v:
ACS Chemical Biology. 10:2570-2579
Polo-like kinase 1 (Plk1) is a central regulator of mitosis and has been validated as a target for antitumor therapy. The polo-box domain (PBD) of Plk1 regulates its kinase activity and mediates the subcellular localization of Plk1 and its interactio
Autor:
Klaus Langer, Klaus Strebhardt, Birgit Spänkuch, Isabel Steinhauser, Elisabeth Kurunci-Csacsko, Heidrun Wartlick
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 3, Pp 223-234 (2008)
Human serum albumin (HSA) nanoparticles represent a promising tool for targeted drug delivery to tumor cells. The coupling of the antibody trastuzumab to nanoparticles uses the capability of human epidermal growth factor receptor 2 (HER2)-positive ce
Publikováno v:
Oncogene. 26:5793-5807
Commonly used drugs for the treatment of breast cancer patients like paclitaxel and Herceptin often show severe side effects or induce resistance in clinical settings. Thus, we analysed a combination of Plk1 (polo-like kinase 1)-specific small interf
Autor:
Sven Becker, Gesine Bug, Monika Raab, Stephanie Hehlgans, Fiona Pachl, Andrea Krämer, Mourad Sanhaji, Bernhard Kuster, Oliver G. Ottmann, Klaus Strebhardt, Christina Dötsch, Elisabeth Kurunci-Csacsko
Exposure to drugs that interfere with microtubule dynamics block cell cycle progression at mitosis by prolonged activation of the spindle assembly checkpoint (SAC). Cells can evade mitotic arrest and proceed to interphase without chromosome segregati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5180a2597f329b945f815d2367590d7f
https://europepmc.org/articles/PMC5528686/
https://europepmc.org/articles/PMC5528686/