The influence of IS1301 in the capsule biosynthesis locus on meningococcal carriage and disease.

Autor: Elisabeth Kugelberg, Bridget Gollan, Christopher Farrance, Holly Bratcher, Jay Lucidarme, Ana Belén Ibarz-Pavón, Martin C J Maiden, Ray Borrow, Christoph M Tang

Publikováno v: PLoS ONE, Vol 5, Iss 2, p e9413 (2010)

Previously we have shown that insertion of IS1301 in the sia/ctr intergenic region (IGR) of serogroup C Neisseria meningitidis (MenC) isolates from Spain confers increased resistance against complement-mediated killing. Here we investigate the signif

Externí odkaz: https://doaj.org/article/1f7f5ee99f814997860ffe9701bc8f52

Infection: IL-22 controls iron scavenging

Autor: Elisabeth, Kugelberg

Publikováno v: Nature reviews. Immunology. 17(3)

Host immunity limits iron availability to pathogenic bacteria, but whether immunity limits pathogenic bacteria from accessing host heme, the major source of iron in the body, remains unclear. Using Citrobacter rodentium, a mouse enteric pathogen and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c252ef7386fcc9783eaab20ad270fb69
https://pubmed.ncbi.nlm.nih.gov/28286877

Infection: TSLP complements neutrophil killing of bacteria

Autor: Elisabeth, Kugelberg

Publikováno v: Sci Immunol

Community-acquired Staphylococcus aureus infections often present as serious skin infections in otherwise healthy individuals, and have become a world-wide epidemic problem fueled by the emergence of strains with antibiotic resistance, such as methic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::21cd4b2edfc6b4eeeead6d3143bf5b9e
https://pubmed.ncbi.nlm.nih.gov/28783679

Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

Autor: Su Li, Joseph J. E. Caesar, Pietro Roversi, Beverly E. Prosser, Elisabeth Kugelberg, Muriel C. Schneider, Qian Zhang, Christoph M. Tang, Janet E. Deane, Susan M. Lea, Sadik Quoraishi, Robert B. Sim, Steven Johnson, Janet E. Lovett

Publikováno v: Nature
Schneider, M C, Prosser, B E, Caesar, J J E, Kugelberg, E, Li, S, Zhang, Q, Quoraishi, S, Lovett, J E, Deane, J E, Sim, R B, Roversi, P, Johnson, S, Tang, C M & Lea, S M 2009, ' Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates ', Nature, vol. 458, no. 7240, pp. 890-U9 . https://doi.org/10.1038/nature07769

The complement system is an essential component of the innate and acquired immune system(1), and consists of a series of proteolytic cascades that are initiated by the presence of microorganisms. In health, activation of complement is precisely contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007d3e68c89215a97723e6775680bb59
https://doi.org/10.1038/nature07769

THE INTERACTION BETWEEN FACTOR H AND NEISSERIA MENINGITIDIS

Autor: Muriel C. Schneider, Joe Caesar, Christoph M. Tang, Lionel Tan, Elisabeth Kugelberg, Qian Zhang, Susan M. Lea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4ed09f7b8df244b3f5369f75e93313
https://ora.ox.ac.uk/objects/uuid:1aaa1461-881f-444d-9d83-1b6a0fc9d4a2