Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Elisabeth Kowenz-Leutz"'
Autor:
Guillem Torcal Garcia, Elisabeth Kowenz-Leutz, Tian V Tian, Antonis Klonizakis, Jonathan Lerner, Luisa De Andres-Aguayo, Valeriia Sapozhnikova, Clara Berenguer, Marcos Plana Carmona, Maria Vila Casadesus, Romain Bulteau, Mirko Francesconi, Sandra Peiro, Philipp Mertins, Kenneth Zaret, Achim Leutz, Thomas Graf
Publikováno v:
eLife, Vol 12 (2023)
Here, we describe how the speed of C/EBPα-induced B cell to macrophage transdifferentiation (BMT) can be regulated, using both mouse and human models. The identification of a mutant of C/EBPα (C/EBPαR35A) that greatly accelerates BMT helped to ill
Externí odkaz:
https://doaj.org/article/e1e5d33715b64c80af5205c035c652f0
Autor:
Evelyn Ramberger, Valeria Sapozhnikova, Elisabeth Kowenz-Leutz, Karin Zimmermann, Nathalie Nicot, Petr V. Nazarov, Daniel Perez-Hernandez, Ulf Reimer, Philipp Mertins, Gunnar Dittmar, Achim Leutz
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102686- (2021)
Summary: C/EBPα represents a paradigm intrinsically disordered transcription factor containing short linear motifs and post-translational modifications (PTM). Unraveling C/EBPα protein interaction networks is a prerequisite for understanding the mu
Externí odkaz:
https://doaj.org/article/ffaf33db25f0418896d38ec650bd59eb
Autor:
Gunnar Dittmar, Daniel Perez Hernandez, Elisabeth Kowenz-Leutz, Marieluise Kirchner, Günther Kahlert, Radoslaw Wesolowski, Katharina Baum, Maria Knoblich, Maria Hofstätter, Arnaud Muller, Jana Wolf, Ulf Reimer, Achim Leutz
Publikováno v:
iScience, Vol 13, Iss , Pp 351-370 (2019)
Summary: CCAAT enhancer-binding protein beta (C/EBPβ) is a pioneer transcription factor that specifies cell differentiation. C/EBPβ is intrinsically unstructured, a molecular feature common to many proteins involved in signal processing and epigene
Externí odkaz:
https://doaj.org/article/7bcb40579ac84aafa4e30e45ab6c32a9
Autor:
Branko Cirovic, Jörg Schönheit, Elisabeth Kowenz-Leutz, Jelena Ivanovska, Christine Klement, Nina Pronina, Valérie Bégay, Achim Leutz
Publikováno v:
Stem Cell Reports, Vol 8, Iss 2, Pp 346-359 (2017)
The lymphoid-myeloid transdifferentiation potentials of members of the C/EBP family (C/EBPα, β, δ, and ε) were compared in v-Abl-immortalized primary B cells. Conversion of B cells to macrophages was readily induced by the ectopic expression of a
Externí odkaz:
https://doaj.org/article/c9760a28c0b748a4adbe5b63f0f95252
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65169 (2013)
The transcription factor C/EBPβ controls differentiation, proliferation, and functionality of many cell types, including innate immune cells. A detailed molecular understanding of how C/EBPβ directs alternative cell fates remains largely elusive. A
Externí odkaz:
https://doaj.org/article/bee7f42a2ec74de386d74419d1727423
Autor:
Guillem Torcal Garcia, Elisabeth Kowenz-Leutz, Tian V. Tian, Antonios Klonizakis, Jonathan Lerner, Luisa de Andrés-Aguayo, Clara Berenguer, Marcos Plana-Carmona, Maria Vila-Casadesús, Romain Bulteau, Mirko Francesconi, Sandra Peiró, Kenneth S. Zaret, Achim Leutz, Thomas Graf
Cell fate decisions are driven by lineage-restricted transcription factors but how they are regulated is incompletely understood. The C/EBPα-induced B cell to macrophage transdifferentiation (BMT) is a powerful system to address this question. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8d409be2038709f5b14f5da6eef25dc
https://doi.org/10.1101/2022.10.03.510647
https://doi.org/10.1101/2022.10.03.510647
Autor:
Karin Zimmermann, Nathalie Nicot, Evelyn Ramberger, Daniel Pérez-Hernández, Valeria Sapozhnikova, Gunnar Dittmar, Achim Leutz, Elisabeth Kowenz-Leutz, Philipp Mertins, Ulf Reimer, Petr V. Nazarov
The pioneering transcription factor C/EBPα coordinates cell fate and cell differentiation. C/EBPα represents an intrinsically disordered protein with multiple short linear motifs and extensive post-translational side chain modifications (PTM), refl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22afbba92b204d74e3375c3b29acce5f
https://doi.org/10.1101/2020.12.28.424569
https://doi.org/10.1101/2020.12.28.424569
Autor:
Gunnar, Dittmar, Daniel Perez, Hernandez, Elisabeth, Kowenz-Leutz, Marieluise, Kirchner, Günther, Kahlert, Radoslaw, Wesolowski, Katharina, Baum, Maria, Knoblich, Maria, Hofstätter, Arnaud, Muller, Jana, Wolf, Ulf, Reimer, Achim, Leutz
Publikováno v:
iScience, Vol 13, Iss, Pp 351-370 (2019)
iScience
iScience
Summary CCAAT enhancer-binding protein beta (C/EBPβ) is a pioneer transcription factor that specifies cell differentiation. C/EBPβ is intrinsically unstructured, a molecular feature common to many proteins involved in signal processing and epigenet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0069ea19511636ad79c695dbf375d61d
http://edoc.mdc-berlin.de/18099/1/18099oa.pdf
http://edoc.mdc-berlin.de/18099/1/18099oa.pdf
Publikováno v:
Transcription. 2:3-8
C/EBPs are implied in an amazing number of cellular functions: C/EBPs regulate tissue and cell type specific gene expression, proliferation, and differentiation control. C/EBPs assist in energy metabolism, female reproduction, innate immunity, inflam
Publikováno v:
The EMBO Journal
Cellular signalling cascades regulate the activity of transcription factors that convert extracellular information into gene regulation. C/EBPbeta is a ras/MAPkinase signal-sensitive transcription factor that regulates genes involved in metabolism, p