Genetic diversification of persistent Mycobacterium abscessus within cystic fibrosis patients

Autor: Astrid Lewin, Elisabeth Kamal, Torsten Semmler, Katja Winter, Sandra Kaiser, Hubert Schäfer, Lei Mao, Patience Eschenhagen, Claudia Grehn, Jennifer Bender, Carsten Schwarz

Publikováno v: Virulence, Vol 12, Iss 1, Pp 2415-2429 (2021)

Mycobacterium (M.) abscessus infections in Cystic Fibrosis (CF) patients cause a deterioration of lung function. Treatment of these multidrug-resistant pathogens is associated with severe side-effects, while frequently unsuccessful. Insight on M. abs

Externí odkaz: https://doaj.org/article/0f2081c8922a48828890383cafb62789

Integrated microRNA-mRNA-analysis of human monocyte derived macrophages upon Mycobacterium avium subsp. hominissuis infection.

Autor: Jutta Sharbati, Astrid Lewin, Barbara Kutz-Lohroff, Elisabeth Kamal, Ralf Einspanier, Soroush Sharbati

Publikováno v: PLoS ONE, Vol 6, Iss 5, p e20258 (2011)

BackgroundMany efforts have been made to understand basal mechanisms of mycobacterial infections. Macrophages are the first line of host immune defence to encounter and eradicate mycobacteria. Pathogenic species have evolved different mechanisms to e

Externí odkaz: https://doaj.org/article/4b6100548ce2466da5d35aeefcdff7ee

Environmental Mycobacterium avium subsp. hominissuis have a higher probability to act as a recipient in conjugation than clinical strains

Autor: Abdelfattah Selim, Elisabeth Kamal, Wilbert Bitter, Faysal Hamouda, Astrid Lewin, Elsayed Galila, Anna M. Oschmann, Carsten Schwarz, Torsten Semmler, Salma A. Shoulah

Publikováno v: Shoulah, S A, Oschmann, A M, Selim, A, Semmler, T, Schwarz, C, Kamal, E, Hamouda, F, Galila, E, Bitter, W & Lewin, A 2018, ' Environmental Mycobacterium avium subsp. hominissuis have a higher probability to act as a recipient in conjugation than clinical strains ', Plasmid, vol. 95, pp. 28-35 . https://doi.org/10.1016/j.plasmid.2018.01.003
Plasmid, 95, 28-35. Elsevier
Plasmid, 95, 28-35. Academic Press Inc.

Mycobacterium avium subsp. hominissuis (MAH) is a widespread opportunistic pathogen that can be isolated from environment (dust, soil and water) and patients with lung or lymphnode infection. In our previous research we revealed the pronounced geneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5fa1822374fa7dccc8c4d0bc198adef
https://research.vu.nl/en/publications/78aa331c-33a6-4af1-859e-70ea10355c84

Abundance of Mycobacterium avium ssp. hominissuis in soil and dust in Germany - implications for the infection route

Autor: Astrid Lewin, J. Kneisel, Elisabeth Kamal, I. Kloster, Annesha Lahiri

Publikováno v: Letters in applied microbiology. 59(1)

UNLABELLED The nontuberculous mycobacteria (NTM) are a heterogeneous group of bacteria found in soil, water and dust. The spread of NTM infection depends on the exposure to reservoirs with high proportions of mycobacteria, the virulence of the NTM st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4302e93ee65d1d86575e0e868b6071
https://pubmed.ncbi.nlm.nih.gov/24612016

The role of the mycobacterial DNA-binding protein 1 (MDP1) from Mycobacterium bovis BCG in host cell interaction

Autor: Elisabeth Kamal, Ralph Kunisch, Astrid Lewin

Publikováno v: BMC Microbiology, Vol 12, Iss 1, p 165 (2012)
BMC Microbiology

Background Mycobacterium tuberculosis differs from most pathogens in its ability to multiply inside monocytes and to persist during long periods of time within granuloma in a status of latency. A class of proteins called mycobacterial histone-like pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde08368f65a75da68d74326f1a6e935
http://www.biomedcentral.com/1471-2180/12/165