Extracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy

Autor: Judy R. van Beijnum, Elisabeth J. M. Huijbers, Karlijn van Loon, Athanasios Blanas, Parvin Akbari, Arno Roos, Tse J. Wong, Stepan S. Denisov, Tilman M. Hackeng, Connie R. Jimenez, Patrycja Nowak-Sliwinska, Arjan W. Griffioen

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

The pro-tumorigenic effects of vimentin have been attributed to intracellular functions in tumour cells so far. Here, the authors show that tumour endothelial cells can secrete vimentin as a pro-angiogenic factor and that targeting of vimentin can be

Externí odkaz: https://doaj.org/article/940243d65bf0461c97115d8cd768c41f

COVID-19 is a systemic vascular hemopathy

Autor: Maximilian Ackermann, Gerald B. Pier, Coert Margadant, Coralie L. Guerin, David M. Smadja, Olivier Sanchez, Nicolas Gendron, Michael Laffan, Elisabeth J. M. Huijbers, Jean-Luc Diehl, Patrycja Nowak-Sliwinska, Steven J. Mentzer, Stéphanie Pons, Anna M. Randi, Arjan W. Griffioen, Michaela Fontenay, Danny Jonigk, Christian Karagiannidis, Philipp Kümpers, Julie Helms, Aurélien Philippe, Richard Chocron, David Skurnik, Nicolas Chapuis

Publikováno v: Smadja, D M, Mentzer, S J, Fontenay, M, Laffan, M A, Ackermann, M, Helms, J, Jonigk, D, Chocron, R, Pier, G B, Gendron, N, Pons, S, Diehl, J-L, Margadant, C, Guerin, C, Huijbers, E J M, Philippe, A, Chapuis, N, Nowak-Sliwinska, P, Karagiannidis, C, Sanchez, O, Kümpers, P, Skurnik, D, Randi, A M & Griffioen, A W 2021, ' COVID-19 is a systemic vascular hemopathy : insight for mechanistic and clinical aspects ', Angiogenesis, vol. 24, no. 4, pp. 755-788 . https://doi.org/10.1007/s10456-021-09805-6
Angiogenesis

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with vascular inflammation and endothelial injury. Severe forms of SARS-CoV-2 infection induce a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c493ed738231281a75aa1dc6159dd1b7
https://doi.org/10.1007/s10456-021-09805-6

Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergy

Autor: Patrycja Nowak-Sliwinska, Judy R. van Beijnum, Christian J. Griffioen, Zowi R. Huinen, Nadine Grima Sopesens, Ralph Schulz, Samir V. Jenkins, Ruud P. M. Dings, Floris H. Groenendijk, Elisabeth J. M. Huijbers, Victor L. J. L. Thijssen, Eric Jonasch, Florry A. Vyth-Dreese, Ekaterina S. Jordanova, Axel Bex, René Bernards, Tanja D. de Gruijl, Arjan W. Griffioen

Publikováno v: Angiogenesis. Springer Netherlands
Nowak-Sliwinska, P, van Beijnum, J R, Griffioen, C J, Huinen, Z R, Sopesens, N G, Schulz, R, Jenkins, S V, Dings, R P M, Groenendijk, F H, Huijbers, E J M, Thijssen, V L J L, Jonasch, E, Vyth-Dreese, F A, Jordanova, E S, Bex, A, Bernards, R, de Gruijl, T D & Griffioen, A W 2022, ' Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergy ', Angiogenesis . https://doi.org/10.1007/s10456-022-09863-4
Angiogenesis, 26(2), 279-293. Springer Netherlands

Purpose Ongoing angiogenesis renders the tumor endothelium unresponsive to inflammatory cytokines and interferes with adhesion of leukocytes, resulting in escape from immunity. This process is referred to as tumor endothelial cell anergy. We aimed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fd56259da385781a1fbb2ca7f1c118
https://research.vumc.nl/en/publications/9161280f-a17f-4174-aa72-1ff4ff8957d1

Anti-angiogenic agents — overcoming tumour endothelial cell anergy and improving immunotherapy outcomes

Autor: Patrycja Nowak-Sliwinska, Elisabeth J. M. Huijbers, Arjan W. Griffioen, Zowi R. Huinen, Judy R. van Beijnum

Publikováno v: Huinen, Z R, Huijbers, E J M, van Beijnum, J R, Nowak-Sliwinska, P & Griffioen, A W 2021, ' Anti-angiogenic agents — overcoming tumour endothelial cell anergy and improving immunotherapy outcomes ', Nature Reviews Clinical Oncology, vol. 18, no. 8, pp. 527-540 . https://doi.org/10.1038/s41571-021-00496-y

Immune checkpoint inhibitors have revolutionized medical oncology, although currently only a subset of patients has a response to such treatment. A compelling body of evidence indicates that anti-angiogenic therapy has the capacity to ameliorate anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bce0b48f02401c0a7e4efd74041ecd6
https://research.vumc.nl/en/publications/6e164432-1aa7-4992-af47-0ee6c48ab4e0

Secreted frizzled-related protein 2: a key player in noncanonical Wnt signaling and tumor angiogenesis

Autor: Karlijn van Loon, Elisabeth J. M. Huijbers, Arjan W. Griffioen

Publikováno v: van Loon, K, Huijbers, E J M & Griffioen, A W 2021, ' Secreted frizzled-related protein 2: a key player in noncanonical Wnt signaling and tumor angiogenesis ', Cancer and Metastasis Reviews, vol. 40, no. 1, pp. 191-203 . https://doi.org/10.1007/s10555-020-09941-3
Cancer Metastasis Reviews

Secreted frizzled-related proteins (SFRP) are glycoproteins containing a so-called frizzled-like cysteine-rich domain. This domain enables them to bind to Wnt ligands or frizzled (FzD) receptors, making potent regulators of Wnt signaling. As Wnt sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203d571ee657d79ae2d0567684aa03da
https://research.vumc.nl/en/publications/a6ed2234-4539-4d92-971a-dc4e4e614be6