Quantitative proteomics of differentiated primary bronchial epithelial cells from chronic obstructive pulmonary disease and control identifies potential novel host factors post-influenza A virus infection

Autor: Misako Nakayama, Hannah Marchi, Anna M. Dmitrieva, Ashesh Chakraborty, Juliane Merl-Pham, Elisabeth Hennen, Ronan Le Gleut, Clemens Ruppert, Andreas Guenther, Kathrin Kahnert, Jürgen Behr, Anne Hilgendorff, Stefanie M. Hauck, Heiko Adler, Claudia A. Staab-Weijnitz

Publikováno v: Frontiers in Microbiology, Vol 13 (2023)

BackgroundChronic obstructive pulmonary disease (COPD) collectively refers to chronic and progressive lung diseases that cause irreversible limitations in airflow. Patients with COPD are at high risk for severe respiratory symptoms upon influenza vir

Externí odkaz: https://doaj.org/article/197141a76e44486bba3dd67588e9540b

Gli1 mediates lung cancer cell proliferation and Sonic Hedgehog-dependent mesenchymal cell activation.

Autor: Olga Bermudez, Elisabeth Hennen, Ina Koch, Michael Lindner, Oliver Eickelberg

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63226 (2013)

Non-Small-Cell-Lung-Cancer (NSCLC) represents approximately 85% of all lung cancers and remains poorly understood. While signaling pathways operative during organ development, including Sonic Hedgehog (Shh) and associated Gli transcription factors (G

Externí odkaz: https://doaj.org/article/95a692e1d1bc4e90a10a304ff7006c52

Validation of in vitro models for smoke exposure of primary human bronchial epithelial cells

Autor: Jürgen Behr, Rudolf Hatz, Otmar Schmid, Andrea C. Schamberger, Michael Lindner, Claudia A. Staab-Weijnitz, Michal Mastalerz, Elisabeth Hennen, Anne Hilgendorff, Ashesh Chakraborty, Andreas Schröppel, Elisabeth Dick

Publikováno v: Am. J. Physiol. Lung Cell Mol. Physiol. 322, L129-L148 (2021)

RATIONALE: The bronchial epithelium is constantly challenged by inhalative insults including cigarette smoke (CS), a key risk factor for lung disease. In vitro exposure of bronchial epithelial cells using CS extract (CSE) is a widespread alternative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd0c109fc9622c4eca527c65d1c28b83
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63460

Cigarette smoke induces overexpression of active human cathepsin S in lungs from current smokers with or without COPD

Autor: Thomas Baranek, Agnès Petit-Courty, Andrea C. Schamberger, Fabien Lecaille, Ahlame Saidi, Pierre-Marie Andrault, Oliver Eickelberg, Thibault Chazeirat, Damien Sizaret, Mylène Wartenberg, Serge Guyétant, Elisabeth Hennen, Gilles Lalmanach, Justine Renault, Yves Courty, Claudia A. Staab-Weijnitz

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2019, 317 (5), pp.L625-L638. ⟨10.1152/ajplung.00061.2019⟩
Am. J. Physiol. Lung Cell Mol. Physiol. 317, L625-L638 (2019)

International audience; Cigarette smoking has marked effects on lung tissue, including induction of oxidative stress, inflammatory cell recruitment, and a protease/antiprotease imbalance. These effects contribute to tissue remodeling and destruction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ccbff970691c72a8be55cbc9f06d21
https://hal.archives-ouvertes.fr/hal-03604585

Glutathione peroxidase 3 localizes to the epithelial lining fluid and the extracellular matrix in interstitial lung disease

Autor: Oliver Eickelberg, Martina Vasakova, Katharina Heinzelmann, Andrea C. Schamberger, Rudolf Hatz, Matthias Mann, Elisabeth Hennen, Jürgen Behr, Martina Sterclova, Claudia A. Staab-Weijnitz, Isis E. Fernandez, Herbert B. Schiller

Publikováno v: Sci. Rep. 6:29952 (2016)
SCIENTIFIC REPORTS
Scientific Reports

Aberrant antioxidant activity and excessive deposition of extracellular matrix (ECM) are hallmarks of interstitial lung diseases (ILD). It is known that oxidative stress alters the ECM, but extracellular antioxidant defence mechanisms in ILD are inco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148bc8301e639ce200e49c07b786923e
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=49135