Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Elisabeth Grondal"'
Autor:
Zhulin Tan, Nitinchandra D. Patel, Harald Engelhardt, Mark Petronczki, Georg Egger, Elisabeth Grondal, Lyne Lamarre, Joyce C. Leung, Bernadette Sharps, Nizar Haddad, Anke Baum, Andreas Bergner, Andreas Schrenk, Renate Schnitzer, Eugene Chong, Tobias Wunberg, Moriz Mayer, Thomas Gerstberger, Dietrich Böse, Andreas Zoephel, Darryl B. McConnell, Christian Engelhardt, Monika Kriz, Nina C. Gonnella, Mariusz Krawiec, Heinz Stadtmüller, Peter Ettmayer, Jonathan T. Reeves, Julian E. Fuchs, Barbara Hopfgartner, Dirk Scharn, Andreas Grimm, Biljana Peric Simov, Flavio Solca, Gerd Bader, Sandra Döbel, Roland Kousek
Publikováno v:
Journal of Medicinal Chemistry. 62:10272-10293
The epidermal growth factor receptor (EGFR), when carrying an activating mutation like del19 or L858R, acts as an oncogenic driver in a subset of lung tumors. While tumor responses to tyrosine kinase inhibitors (TKIs) are accompanied by marked tumor
Autor:
Elisabeth Grondal, Jale Karolyi-Oezguer, Dorothea Rudolph, Juergen Ramharter, Gerhard Gmaschitz, Geraldine Garavel, Joachim Broeker, Nina Kerres, Julian E. Fuchs, Patrick Werni, Karin S. Hofbauer, Wolfgang Hela, Andreas Gollner, Harald Weinstabl, Darryl B. McConnell
Publikováno v:
Chemmedchem
Mouse double minute 2 (MDM2) is a main and direct inhibitor of the crucial tumor suppressor p53. Reports from initial clinical trials showed that blocking this interaction with a small‐molecule inhibitor can have great value in the treatment of can