Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Elisabeth Gardiner"'
Autor:
Emily Hinchcliff, Elisabeth Gardiner, Shannon Westin, Virginia Bayer, Kelly Rangel, Kathryn Lito, Bryan Fellman, Ying Yuan, Anil Sood, Karen Lu, Amir Jazaeri
Publikováno v:
Gynecologic Oncology. 166:S166-S167
Autor:
Kathleen M. Fisch, Na Wei, Xiang-Lei Yang, Yun-Shiuan Olivia Hsu, Andrew I. Su, Tao Xu, Elisabeth Gardiner, Shuji Kishi, Xiaohua Wu, Guangsen Fu, Yi Shi, Lan N. Truong
Publikováno v:
Molecular Cell. 56:323-332
Tyrosyl-tRNA synthetase (TyrRS) is known for its essential aminoacylation function in protein synthesis. Here we report a new function for TyrRS in DNA damage protection. We found that oxidative stress, which often down-regulates protein synthesis, i
Autor:
Kyle P. Chiang, Wing Hung Wong, Feng Wang, Zhiwen Xu, Paul Schimmel, Kin Fai Au, Wing-Sze Lo, Mingjie Zhang, Min Guo, Elisabeth Gardiner, Ching-Fun Lau, Leslie A. Nangle, Xiang-Lei Yang, Jie J. Zhou, John D. Mendlein
Publikováno v:
Science. 345:328-332
Evolving from an enzyme and into a regulator Proteins, the work-horses of the cell, are made on a messenger RNA (mRNA) template. An enzyme called aminoacyl tRNA synthetases (AARSs) attaches the correct amino acid to a transfer RNA so that mRNA is acc
Autor:
Carol Forster, Chunxiang Sun, Kersi Pestonjamasp, Michael Glogauer, Orion D. Weiner, Ben Bohl, Elisabeth Gardiner, Gary M. Bokoch
Publikováno v:
Blood. 108:2814-2820
Chemotactic responsiveness is crucial to neutrophil recruitment to sites of infection. During chemotaxis, highly divergent cytoskeletal programs are executed at the leading and trailing edge of motile neutrophils. The Rho family of small GTPases play
Publikováno v:
Cancer Research. 77:78-78
Meditope SnAP (site-specific novel antibody platform) technology is a novel way to target molecules to antibodies in a site specific, non-destructive fashion. A “meditope” is a proprietary peptide that can bind a meditope-enabled antibody in a un
Publikováno v:
Cancer Research. 77:64-64
Meditope Biosciences has developed a way to use SnAP technology to promote internalization of antibody receptor complexes through a novel construct called a SnAP-body. Meditope’s SnAP platform functionalizes monoclonal antibodies to bind to specifi
Publikováno v:
Cancer Research. 76:598-598
Therapeutic antibodies can bind to cell-surface receptors, prompting receptor internalization and effectively blocking further stimulation by the cognate receptor ligands. Receptor internalization is also exploited by antibody-drug conjugates (ADC) t
Autor:
Elisabeth Gardiner, John C. Williams, Krzysztof P. Bzymek, Michael H. Matho, Calin Dan Dumitru
Publikováno v:
Cancer Research. 76:869-869
Meditope Biosciences’ SnAP (Site-specific novel Antibody Platform) technology provides a novel and specific way to create antibody drug conjugates (ADCs). Cyclic peptides, termed ‘meditopes’, have been designed to selectively bind to a ‘medit
Publikováno v:
Journal of Clinical Oncology. 34:e14059-e14059
e14059Background: EGFR is a clinically validated target for advanced colorectal carcinoma, but EGFR targeted therapies are useless against EGFR expressing tumors with K/NRAS mutations. We hypothesi...
Publikováno v:
Cancer Research. 75:646-646
Meditopes are cyclic peptides that bind the Fab fragment noncovalently, in a novel and unique site, outside the paratope. This property can be utilized to harness cytotoxic payloads to an antibody in a site-specific and consistent manner. One of the