Cell Shape and Durotaxis Explained from Cell-Extracellular Matrix Forces and Focal Adhesion Dynamics

Autor: Elisabeth G. Rens, Roeland M.H. Merks

Publikováno v: iScience, Vol 23, Iss 9, Pp 101488- (2020)

Summary: Many cells are small and rounded on soft extracellular matrices (ECM), elongated on stiffer ECMs, and flattened on hard ECMs. Cells also migrate up stiffness gradients (durotaxis). Using a hybrid cellular Potts and finite-element model exten

Externí odkaz: https://doaj.org/article/7320d86d53ba4c93929350aa2603fbce

Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro.

Autor: René F M van Oers, Elisabeth G Rens, Danielle J LaValley, Cynthia A Reinhart-King, Roeland M H Merks

Publikováno v: PLoS Computational Biology, Vol 10, Iss 8, p e1003774 (2014)

In vitro cultures of endothelial cells are a widely used model system of the collective behavior of endothelial cells during vasculogenesis and angiogenesis. When seeded in an extracellular matrix, endothelial cells can form blood vessel-like structu

Externí odkaz: https://doaj.org/article/a3b0a727f09e482c8661e4f06e080b92

Spots, stripes, and spiral waves in models for static and motile cells

Autor: Elisabeth G. Rens, Yue Liu, Leah Edelstein-Keshet

Publikováno v: Journal of Mathematical Biology, 82(4)

The polarization and motility of eukaryotic cells depends on assembly and contraction of the actin cytoskeleton and its regulation by proteins called GTPases. The activity of GTPases causes assembly of filamentous actin (by GTPases Cdc42, Rac), resul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045b7e7142f417d5dfcf1f62529b7710
https://doi.org/10.1007/s00285-021-01550-0

Autocrine inhibition of cell motility can drive epithelial branching morphogenesis in the absence of growth

Autor: Iraes Rabbers, Roeland M. H. Merks, Elisabeth G. Rens, Mathé T. Zeegers, András Szabó

Publikováno v: Philosophical Transactions of the Royal Society of London Series B: Biological Sciences, 375(1807). The Royal Society
Philosophical Transactions of the Royal Society B, 375(1807)
Philos Trans R Soc Lond B Biol Sci

Epithelial branching morphogenesis drives the development of organs such as the lung, salivary gland, kidney and the mammary gland. It involves cell proliferation, cell differentiation and cell migration. An elaborate network of chemical and mechanic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069e1e6a73754bbf0dd3c69a82f1e011
http://hdl.handle.net/1887/3238969

Cell Shape and Durotaxis Follow from Mechanical Cell-Substrate Reciprocity and Focal Adhesion Dynamics: A Unifying Mathematical Model

Autor: Elisabeth G. Rens, Roeland M. H. Merks

Publikováno v: SSRN Electronic Journal.

Many animal cells change their shape depending on the stiffness of the substrate on which they are cultured: they assume small, rounded shapes in soft ECMs, they elongate within stiffer ECMs, and flatten out on hard substrates. Cells tend to prefer s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edea0442fad45f93a3dd16be203f445e
https://doi.org/10.2139/ssrn.3569534