Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Elisabeth Freyer"'
Autor:
Timothy James Kendall, Catherine Mary Duff, Luke Boulter, David H. Wilson, Elisabeth Freyer, Stuart Aitken, Stuart John Forbes, John Peter Iredale, Nicholas Dixon Hastie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Activated hepatic stellate cells of putative mesodermal origin orchestrate scarring during injury. Here, the authors define a discrete morphologically plastic lineage of embryonic mesothelial-derived scar-orchestrating cells, through a distinct quies
Externí odkaz:
https://doaj.org/article/2053b287b6104ed8b2c5a1835405ee3e
Autor:
Mark T. Handley, André Mégarbané, Alison M. Meynert, Stephen Brown, Elisabeth Freyer, Martin S. Taylor, Ian J. Jackson, Irene A. Aligianis
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 2, Iss 4, Pp 319-325 (2014)
Abstract Autosomal recessive cutis laxa type 3A is caused by mutations in ALDH18A1, a gene encoding the mitochondrial enzyme ∆1‐pyrroline‐5‐carboxylate synthase (P5CS). It is a rare disorder with only six pathogenic mutations and 10 affected
Externí odkaz:
https://doaj.org/article/ebe39d83cd9e4ac9b1cc74a82d2be71d
Autor:
You-Ying Chau, David Brownstein, Heidi Mjoseng, Wen-Chin Lee, Natalija Buza-Vidas, Claus Nerlov, Sten Eirik Jacobsen, Paul Perry, Rachel Berry, Anna Thornburn, David Sexton, Nik Morton, Peter Hohenstein, Elisabeth Freyer, Kay Samuel, Rob van't Hof, Nicholas Hastie
Publikováno v:
PLoS Genetics, Vol 7, Iss 12, p e1002404 (2011)
There is much interest in the mechanisms that regulate adult tissue homeostasis and their relationship to processes governing foetal development. Mice deleted for the Wilms' tumour gene, Wt1, lack kidneys, gonads, and spleen and die at mid-gestation
Externí odkaz:
https://doaj.org/article/5b754ee38bb04229ad7234cf55d68a2e
Autor:
Fraser R. Millar, Adam Pennycuick, Morwenna Muir, Andrea Quintanilla, Priya Hari, Elisabeth Freyer, Philippe Gautier, Alison Meynert, Graeme Grimes, Carla Salomo Coll, Sofia Zdral, Stella Victorelli, Vitor H. Teixeira, John Connelly, João F. Passos, Marian A. Ros, William A.H. Wallace, Margaret C. Frame, Andrew H. Sims, Luke Boulter, Sam M. Janes, Simon Wilkinson, Juan Carlos Acosta
Publikováno v:
Cell Reports, 2022, 41(6), 111596
Targeting early-stage lung cancer is vital to improve survival. However, the mechanisms and components of the early tumor suppressor response in lung cancer are not well understood. In this report, we study the role of Toll-like receptor 2 (TLR2), a
Autor:
Andrea Quintanilla, Alison M. Meynert, Margaret C. Frame, Simon Wilkinson, Priya Hari, Adam Pennycuick, Luke Boulter, Elisabeth Freyer, Wallace Wa, John C. Connelly, Sam M. Janes, Juan Carlos Acosta, Morwenna Muir, Andrew H. Sims, Philippe Gautier, Vitor H. Teixeira, Fraser R. Millar
Targeting early-stage lung cancer is vital to improve overall survival. We previously identified Toll-like receptor 2 (TLR2) as a regulator of oncogene-induced senescence (OIS) and the senescence-associated secretory phenotype (SASP), both key for tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b30039cd74356b79013c5e3a858bc0e
https://doi.org/10.1101/2021.06.04.446876
https://doi.org/10.1101/2021.06.04.446876
Autor:
John P. Iredale, Nicholas D. Hastie, Elisabeth Freyer, Stuart Aitken, Stuart J. Forbes, David H. Wilson, Catherine M. Duff, Timothy J. Kendall, Luke Boulter
Publikováno v:
Kendall, T, Duff, C, Boulter, L, Wilson, D, Freyer, E, Aitken, S, Forbes, S, Iredale, J & Hastie, N 2019, ' Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1 ', Nature Communications . https://doi.org/10.1038/s41467-019-12701-9
Kendall, T J, Duff, C M, Boulter, L, Wilson, D H, Freyer, E, Aitken, S, Forbes, S J, Iredale, J P & Hastie, N D 2019, ' Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1 ', Nature Communications, vol. 10, no. 1, 4688 . https://doi.org/10.1038/s41467-019-12701-9
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications
Kendall, T J, Duff, C M, Boulter, L, Wilson, D H, Freyer, E, Aitken, S, Forbes, S J, Iredale, J P & Hastie, N D 2019, ' Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1 ', Nature Communications, vol. 10, no. 1, 4688 . https://doi.org/10.1038/s41467-019-12701-9
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications
Activated hepatic stellate cells (aHSCs) orchestrate scarring during liver injury, with putative quiescent precursor mesodermal derivation. Here we use lineage-tracing from development, through adult homoeostasis, to fibrosis, to define morphological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a05737ec3f92304253e8aa825bcdf60
https://www.pure.ed.ac.uk/ws/files/116286436/s41467_019_12701_9.pdf
https://www.pure.ed.ac.uk/ws/files/116286436/s41467_019_12701_9.pdf
Autor:
Paul Perry, Kay Samuel, Anna Thornburn, Heidi K. Mjoseng, Nicholas D. Hastie, David Sexton, Natalija Buza-Vidas, Wen-Chin Lee, Elisabeth Freyer, David Brownstein, You-Ying Chau, Sten Eirik W. Jacobsen, Nik M. Morton, Rob van't Hof, Peter Hohenstein, Rachel L. Berry, Claus Nerlov
Publikováno v:
Chau, Y-Y, Brownstein, D, Mjoseng, H, Lee, W-C, Buza-Vidas, N, Nerlov, C, Jacobsen, S E, Perry, P, Berry, R, Thornburn, A, Sexton, D, Morton, N, Hohenstein, P, Freyer, E, Samuel, K, van 't Hof, R & Hastie, N 2011, ' Acute Multiple Organ Failure in Adult Mice Deleted for the Developmental Regulator Wt1 ', PLoS Genetics, vol. 7, no. 12, e1002404 . https://doi.org/10.1371/journal.pgen.1002404
PLoS Genetics, Vol 7, Iss 12, p e1002404 (2011)
PLoS Genetics
PLoS Genetics, Vol 7, Iss 12, p e1002404 (2011)
PLoS Genetics
There is much interest in the mechanisms that regulate adult tissue homeostasis and their relationship to processes governing foetal development. Mice deleted for the Wilms' tumour gene, Wt1, lack kidneys, gonads, and spleen and die at mid-gestation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e250ebb18a2166bf30d4527c61b6e9
https://www.pure.ed.ac.uk/ws/files/7731660/Acute_multiple_organ_failure_in_adult_mice_deleted_for_the_developmental_regulator_Wt1.pdf
https://www.pure.ed.ac.uk/ws/files/7731660/Acute_multiple_organ_failure_in_adult_mice_deleted_for_the_developmental_regulator_Wt1.pdf
Autor:
Kay Samuel, Joan Slight, David Dow, You-Ying Chau, David G. Brownstein, Martin Waterfall, Elisabeth Freyer, Nicholas D. Hastie
Publikováno v:
Mechanisms of Development. 126:S84-S85