Methotrexate as a corticosteroid-sparing agent in leprosy reactions: A French multicenter retrospective study.

Autor: Léa Jaume, Estelle Hau, Gentiane Monsel, Antoine Mahé, Antoine Bertolotti, Antoine Petit, Britney Le, Marie Chauveau, Elisabeth Duhamel, Thierry Maisonobe, Martine Bagot, Jean-David Bouaziz, Faïza Mougari, Emmanuelle Cambau, Marie Jachiet, Groupe d’infectiologie en dermatologie et des infections sexuellement transmissibles (GrIDIST)

Publikováno v: PLoS Neglected Tropical Diseases, Vol 17, Iss 4, p e0011238 (2023)

IntroductionLeprosy reactions (LRs) are inflammatory responses observed in 30%-50% of people with leprosy. First-line treatment is glucocorticoids (GCs), often administered at high doses with prolonged courses, resulting in high morbi-mortality. Meth

Externí odkaz: https://doaj.org/article/c3a29e16bf9b4501aab9f6483ea73f30

Frequency and Predictors for Chronic Thromboembolic Pulmonary Hypertension after a first Unprovoked Pulmonary Embolism: results from PADIS studies

Autor: Alexandre Fauché, Emilie Presles, Olivier Sanchez, Xavier Jaïs, Raphael Le Mao, Philippe Robin, Gilles Pernod, Laurent Bertoletti, Patrick Jego, Florence Parent, Catherine A. Lemarié, Florent Leven, Pierre‐Yves Le Roux, Pierre‐Yves Salaun, Michel Nonent, Philippe Girard, Karine Lacut, Laurent Savale, Solen Mélac, Marie Guégan, Patrick Mismetti, Silvy Laporte, Christophe Leroyer, David Montani, Francis Couturaud, Cécile Tromeur, Guy Meyer, Elisabeth Duhamel, Karine Provost, Dominique Mottier, Aurélia Le Hir, Stéphane Lenoir, Christian Lamer, Jean François Bergmann, Denis Wahl, Ludovic Drouet, Patrick Chevarier, Nicolas Monte, Florence Morvan, Véronique Kouassi, Nabahats Ibrir, Gaid El Asri, Pierre Yves Salaun, Pierre Yves Le Roux, Luc Bressollette, Philippe Quéhé, Simon Gestin, Jérôme Bahuon, Lucille Deloire, Benjamin Planquette, Yannick Jobic, Yves Etienne, Romain Didier, Loic Leroux, Hubert Galinat, Cédric Le Maréchal, Lénaïck Gourhant, Fanny Mingant, Emmanuelle Lemoigne, Luc De Saint Martin, Aurélien Delluc, Grégoire Le Gal, Nicolas Paleiron, Raphaël Le Mao, Christophe Pison, Philippe Guéret, Hervé Décousus, Sandrine Accassat

Publikováno v: Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, 2022, 20 (12), pp.2850-2861. ⟨10.1111/jth.15866⟩

International audience; Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening pulmonary embolism's (PE) complication whose incidence and predictors are not precisely determined.Objective: To determine the frequency a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02aa673c913404a0d78cb9a0aded90a
https://hal-univ-rennes1.archives-ouvertes.fr/hal-03800679/document

Risk factors for recurrent venous thromboembolism after unprovoked pulmonary embolism: the PADIS-PE randomised trial

Autor: Florent Leven, Solen Melac, Patrick Jego, Michel Nonent, Philippe Robin, Christophe Leroyer, Pierre-Yves Le Roux, Silvy Laporte, Elisabeth Duhamel, Florence Parent, Guy Meyer, Emilie Presles, Laurent Bertoletti, Cécile Tromeur, Dominique Mottier, Lucile Deloire, Philippe Girard, Francis Couturaud, Patrick Mismetti, Pierre-Yves Salaun, Karine Provost, Gilles Pernod, Brigitte Pan-Petesch, Olivier Sanchez, Fanny Mingant, Benjamin Planquette, Luc Bressollette, Karine Lacut

Publikováno v: European Respiratory Journal
European Respiratory Journal, European Respiratory Society, 2018, 51 (1), pp.1701202. ⟨10.1183/13993003.01202-2017⟩

We aimed to identify risk factors for recurrent venous thromboembolism (VTE) after unprovoked pulmonary embolism.Analyses were based on the double-blind randomised PADIS-PE trial, which included 371 patients with a first unprovoked pulmonary embolism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b88b9af7b2f5cbf8b07c8257702525
https://hal.univ-brest.fr/hal-02059217

Six Months vs Extended Oral Anticoagulation After a First Episode of Pulmonary Embolism: The PADIS-PE Randomized Clinical Trial

Autor: Karine Provost, Gilles Pernod, Francis Couturaud, Philippe Castellant, Philippe Lorillon, Karine Lacut, Patrick Jego, Silvy Laporte, Elisabeth Duhamel, Jean-Luc Bosson, Patrick Mismetti, Christophe Leroyer, Claire Bal dit Sollier, Dominique Mottier, Pierre-Yves Salaun, Marie Guegan, Florence Parent, Philippe Girard, Michel Nonent, Emilie Presles, Hervé Decousus, Olivier Sanchez, Guy Meyer, Luc Bressollette

Publikováno v: Journal of the American Medical Association
Journal of the American Medical Association, American Medical Association (AMA), 2015, 314 (1), pp.31-40. ⟨10.1001/jama.2015.7046⟩
Journal of the American Medical Association, American Medical Association (AMA), 2015, 314 (1), pp.31-40. 〈10.1001/jama.2015.7046〉

International audience; The optimal duration of anticoagulation after a first episode of unprovoked pulmonary embolism is uncertain. To determine the benefits and harms of an additional 18-month treatment with warfarin vs placebo, after an initial 6-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e22969b36d471c32c48d9e0c9db234
https://hal.univ-brest.fr/hal-01259554

Two Years Versus Six Months of Oral Anticoagulation after a First Episode of Unprovoked Pulmonary Embolism: The Padis PE Multicenter, Double-Blind, Randomized Trial

Autor: Philippe Girard, Patrick Jego, Gilles Pernod, Patrick Mismetti, Marie Guegan, Karine Lacut, Philippe Castellant, Olivier Sanchez, Jean-Luc Bosson, Francis Couturaud, Silvy Laporte, Claire Bal dit Sollier, Elisabeth Duhamel, Michel Nonent, Luc Bressollette, Karine Provost, Emilie Presles, Hervé Decousus, Pierre-Yves Salaun, Christophe Leroyer, Guy Meyer, Philippe Lorillon, Dominique Mottier, Florence Parent

Publikováno v: Blood. 124:LBA-3

Background: Patients with a first episode of unprovoked pulmonary embolism have a high risk of recurrent venous thromboembolism (VTE) after anticoagulation is discontinued. Prolongation of anticoagulant therapy beyond the initial period of 3 to 6 mon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::898fd1b9dc7f7082b09b2d42110df948
https://doi.org/10.1182/blood.v124.21.lba-3.lba-3