Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Elisabeth Doyle"'
Autor:
William P. Taylor, Mark Edward Bunnage, Hardwin O'dowd, Michael P. Clark, Dan Crawford, Sanjay Shivayogi Magavi, Bin Song, Jianglin Liang, Timothy J. Senter, Tal Kramer, Juntyma J. Engtrakul, Arun K. Mohanty, Fan Lu, Hong Gao, Yulin Huang, Swett Rebecca Jane, Bryan W. Vought, Ray Winquist, Tony Considine, Ganesh Iyer, Kenneth C. Bonanno, Elisabeth Doyle, Suganthini Nanthakumar, Raymond Kemper, Elaine Krueger, Cameron Stuver Moody, Joyce T. Coll, Paul S. Charifson, John J. Court, Wenxin Gu, Francois Maltais, Gale-Day Zachary, Ananthisrinivas Chakilam, Jon H. Come, John L. Andreassi, Morris Mark A, Brinley Furey, Christina Boucher, Martin Sanders, Harmon J. Zuccola, Gagnon Kevin James, Katrina L. Jackson, Lu Gan, Jonathan A. Phillips
Publikováno v:
Journal of Medicinal Chemistry. 64:17753-17776
Accumulation of very long chain fatty acids (VLCFAs) due to defects in ATP binding cassette protein D1 (ABCD1) is thought to underlie the pathologies observed in adrenoleukodystrophy (ALD). Pursuing a substrate reduction approach based on the inhibit
Autor:
Natasha Rose Morrison, Valerie May Swift, Sharon Anne Weeks, June Elisabeth Doyle, Peter Richmond, Deborah Lehmann, Holly Jane Richmond, Christopher G. Brennan-Jones
Publikováno v:
Deafness & Education International. 22:255-274
The majority of Australian Aboriginal and Torres Strait Islander (hereafter referred to as “Aboriginal”) people live in urban centres. Otitis media (OM) occurs at a younger age, prevalence is highe...
Autor:
Chau Mak, Luca Settimo, Guy Brenchley, Francoise Pierard, Andrew Miller, Dean Boyall, Philip N. Collier, Adam Tanner, Heather Twin, Clare M. Bolton, Peter Chiu, Juan-Miguel Jimenez, Shazia Keily, Elisabeth Doyle, Adam P. Curnock, Ronald Knegtel, Christopher John Davis
Publikováno v:
ACS Med Chem Lett
[Image: see text] PKCθ plays an important role in T cell biology and is a validated target for a number of disease states. A series of potent and selective PKCθ inhibitors were designed and synthesized starting from a HTS hit compound. Cell activit
Autor:
Elisabeth Doyle
Sam, also known as Sammy Puppy Doggy, the Big Friendly Wolf, is a beautiful, intelligent, energetic, and funny German Shepherd. Every day is a new adventure, full of fun, games, laughter, and discoveries. Sam's mom and brothers, Will and James, showe
Autor:
Andrey Peresypkin, Setu Roday, Stavropoulos Kathy, Wojciech Dworakowski, Nti-Addae Kwame Wiredu, Elisabeth Doyle, Jim Bernhard
Publikováno v:
Journal of pharmaceutical sciences. 110(7)
In Drug Discovery, pharmacology studies often require benign formulation compositions for safe administration in animal models. Here, we applied Adaptive Focused Acoustics™ (AFA) to a molecular scaffold with challenging physicochemical properties f
Autor:
Clare M. Bolton, Peter Weber, Peter Chiu, Julie Jones, Damien Fraysse, Jimenez Juan Miguel, Elisabeth Doyle, Matthias Hesse, Adam P. Curnock
Publikováno v:
Biochemical Society Transactions. 42:1524-1528
Protein kinase Cθ (PKCθ) is a member of a large family of serine/threonine kinases that are involved in diverse cellular functions. PKCθ has roles in T-cell activation and survival, where the dependency of T-cell responses on this enzyme appears t
Autor:
Paolo A. Centrella, Christopher C. Arico-Muendel, Gary M. Olson, Jennifer L Svendsen, Matthew T. Labenski, Steven R. Skinner, Charles D. Thompson, Christopher L. Paradise, Dennis Benjamin, Barbara C. Sluboski, Kenneth E Lind, Brooke D. Contonio, Teresa M Caiazzo, Christopher Self, Gerhard Hannig, Barry A. Morgan, William F. Westlin, Elisabeth Doyle, Charles M. Cook, Kerry White, Lily Lee Searle
Publikováno v:
Journal of Medicinal Chemistry. 52:8047-8056
Inhibition of methionine aminopeptidase-2 (MetAP2) represents a novel approach to antiangiogenic therapy. We describe the synthesis and activity of fumagillin analogues that address the pharmacokinetic and safety liabilities of earlier candidates in
Autor:
Ghotas Evindar, Amy Hutchings, Jeanine Lorusso, Albion D. Wright, Michael Kelley, Sylvie G. Bernier, Keith Halley, Barry A. Morgan, William F. Westlin, Elisabeth Doyle, Nazbeh Taghizadeh, Gerhard Hannig, Alexander L. Satz, Malcolm J. Kavarana, Ashis K. Saha
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2315-2319
In pursuit of potent and selective sphingosine-1-phosphate receptor agonists, we have utilized previously reported phenylamide and phenylimidazole scaffolds to explore extensive side-chain modifications to generate new molecular entities. A number of
Autor:
Hongfeng Deng, Jeanine Lorusso, Ghotas Evindar, Barry A. Morgan, William F. Westlin, Sylvie G. Bernier, Elisabeth Doyle
Publikováno v:
ACS medicinal chemistry letters. 4(10)
To develop effective oral treatment for multiple sclerosis (MS), we discovered a series of alkyl-substituted biaryl amino alcohols as selective S1P1 modulators. One exemplar is (S)-2-amino-2-(5-(4-(octyloxy)-3-(trifluoromethyl)phenyl)-1,3,4-thiadiazo
Autor:
Gary K. O’Donovan, Steven R. Skinner, Barry A. Morgan, Bruce Belanger, Matthew T. Labenski, Kerry White, Dennis Benjamin, Paolo A. Centrella, Elisabeth Doyle, Heather S. Blanchette, Ulrike Gradhand, Nazbeh Taghizadeh, Sarah T Griffin, Teresa M Caiazzo, Kavirayani R. Prasad, James Wakefield, William F. Westlin, Jennifer L. DeLorey, Susan E. Hill, Charles D. Thompson, Christopher C. Arico-Muendel
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 41(4)
The natural product fumagillin exhibits potent antiproliferative and antiangiogenic properties. The semisynthetic analog PPI-2458, [(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] N-[(2R)-1-am