Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Elisabeth D. Galsgaard"'
Autor:
Paul Horn, Jenny Norlin, Kasper Almholt, Birgitte M Viuff, Elisabeth D Galsgaard, Andreas Hald, Franziska Zosel, Helle Demuth, Svend Poulsen, Peder L Norby, Morten G Rasch, Mogens Vyberg, Jan Fleckner, Mikkel Parsberg Werge, Lise Lotte Gluud, Marco R Rink, Emma Shepherd, Ellie Northall, Patricia F Lalor, Chris J Weston, Morten Fog-Tonnesen, Philip N Newsome
Publikováno v:
eLife, Vol 13 (2024)
Gremlin-1 has been implicated in liver fibrosis in metabolic dysfunction-associated steatohepatitis (MASH) via inhibition of bone morphogenetic protein (BMP) signalling and has thereby been identified as a potential therapeutic target. Using rat in v
Externí odkaz:
https://doaj.org/article/26db31e3cfc948118f0e0cdf01eb4818
Autor:
Jaime Moreno, Lise Lotte Gluud, Elisabeth D Galsgaard, Henning Hvid, Gianluca Mazzoni, Vivek Das
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0302853 (2024)
BackgroundChronic Kidney Disease (CKD) and Metabolic dysfunction-associated steatohepatitis (MASH) are metabolic fibroinflammatory diseases. Combining single-cell (scRNAseq) and spatial transcriptomics (ST) could give unprecedented molecular disease
Externí odkaz:
https://doaj.org/article/110996befe404f2b8fc3f222e410c0c1
Autor:
Natascha Roehlen, Antonio Saviano, Houssein El Saghire, Emilie Crouchet, Zeina Nehme, Fabio Del Zompo, Frank Jühling, Marine A. Oudot, Sarah C. Durand, François H. T. Duong, Sara Cherradi, Victor Gonzalez Motos, Nuno Almeida, Clara Ponsolles, Laura Heydmann, Tessa Ostyn, Antonin Lallement, Patrick Pessaux, Emanuele Felli, Andrea Cavalli, Jacopo Sgrignani, Christine Thumann, Olga Koutsopoulos, Bryan C. Fuchs, Yujin Hoshida, Maike Hofmann, Mogens Vyberg, Birgitte Martine Viuff, Elisabeth D. Galsgaard, Greg Elson, Alberto Toso, Markus Meyer, Roberto Iacone, Tamas Schweighoffer, Geoffrey Teixeira, Solange Moll, Claudio De Vito, Tania Roskams, Irwin Davidson, Danijela Heide, Mathias Heikenwälder, Mirjam B. Zeisel, Joachim Lupberger, Laurent Mailly, Catherine Schuster, Thomas F. Baumert
Publikováno v:
Roehlen, N, Saviano, A, El Saghire, H, Crouchet, E, Nehme, Z, Del Zompo, F, Jühling, F, Oudot, M A, Durand, S C, Duong, F H T, Cherradi, S, Gonzalez Motos, V, Almeida, N, Ponsolles, C, Heydmann, L, Ostyn, T, Lallement, A, Pessaux, P, Felli, E, Cavalli, A, Sgrignani, J, Thumann, C, Koutsopoulos, O, Fuchs, B C, Hoshida, Y, Hofmann, M, Vyberg, M, Viuff, B M, Galsgaard, E D, Elson, G, Toso, A, Meyer, M, Iacone, R, Schweighoffer, T, Teixeira, G, Moll, S, De Vito, C, Roskams, T, Davidson, I, Heide, D, Heikenwälder, M, Zeisel, M B, Lupberger, J, Mailly, L, Schuster, C & Baumert, T F 2022, ' A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity ', Science Translational Medicine, vol. 14, no. 676, eabj4221, pp. eabj4221 . https://doi.org/10.1126/scitranslmed.abj4221
Tissue fibrosis is a key driver of end-stage organ failure and cancer, overall accounting for up to 45% of deaths in developed countries. There is a large unmet medical need for antifibrotic therapies. Claudin-1 (CLDN1) is a member of the tight junct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a15761706f515b3e02c2102683616d7
https://vbn.aau.dk/da/publications/ae147006-4f6f-4e57-bf99-f23fc8da0fa9
https://vbn.aau.dk/da/publications/ae147006-4f6f-4e57-bf99-f23fc8da0fa9
Autor:
Henrik Søndergaard, Fredrik Wolfhagen Sand, Elisabeth D. Galsgaard, Constanze Hess, Sisse A Nørgaard, Dorte Bratbo Sørensen
Publikováno v:
Laboratory Animals. 54:341-352
The streptozotocin (STZ)-induced diabetic mouse model has been extensively used as a model for diabetes and diabetic nephropathy, but it is still influenced by many off-target toxic effects and large variation in diabetes induction. Therefore, the ai
Autor:
Adrian McCann, Anne Bugge, Mikkel Werge, Nicolai J. Wewer Albrechtsen, Dorte Holst, Lise Lotte Gluud, Elisabeth D. Galsgaard
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 1081, p 1081 (2021)
Werge, M P, McCann, A, Galsgaard, E D, Holst, D, Bugge, A, Albrechtsen, N J W & Gluud, L L 2021, ' The Role of the Transsulfuration Pathway in Non-Alcoholic Fatty Liver Disease ', Journal of Clinical Medicine, vol. 10, no. 5, 1081 . https://doi.org/10.3390/jcm10051081
Journal of Clinical Medicine
Werge, M P, McCann, A, Galsgaard, E D, Holst, D, Bugge, A, Albrechtsen, N J W & Gluud, L L 2021, ' The Role of the Transsulfuration Pathway in Non-Alcoholic Fatty Liver Disease ', Journal of Clinical Medicine, vol. 10, no. 5, 1081 . https://doi.org/10.3390/jcm10051081
Journal of Clinical Medicine
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing and approximately 25% of the global population may have NAFLD. NAFLD is associated with obesity and metabolic syndrome, but its pathophysiology is complex and only partly under
Autor:
Jens Høiriis Nielsen, Ulrik L. Henriksen, Elisabeth D. Galsgaard, Martin N. Lindberg, Louise Torp Dalgaard, Annette Møldrup
Publikováno v:
Moldrup, A, Lindberg, M N, Galsgaard, E D, Henriksen, U, Dalgaard, L T & Nielsen, J H 2020, ' Regulation of integrin alpha 6A by lactogenic hormones in rat pancreatic beta-cells : Implications for the physiological adaptation to pregnancy ', Acta Physiologica, vol. 229, no. 3, 13454 . https://doi.org/10.1111/apha.13454
Aim During pregnancy, the maternal beta-cell mass is increased in order to adapt to the physiological changes in insulin demand. Lactogenic hormones stimulate rodent beta-cell attachment and proliferation in vitro. The aim of this study was to identi
Autor:
James C. Ryan, Kasper Vadstrup, Teis Jensen, Lewis L. Lanier, Helle Jensen, Marianne K Vester-Andersen, Shih-Yu Chen, Elisabeth D. Galsgaard, Flemming Bendtsen, Jens Gerwien, Garry P. Nolan, Julie Steen Pedersen
Publikováno v:
Experimental and molecular pathology, vol 103, iss 1
Interaction between the activating NKG2D receptor on lymphocytes and its ligands MICA, MICB, and ULBP1–6 modulate T and NK cell activity and may contribute to the pathogenesis of Crohn’s disease (CD). NKG2D ligands are generally not expressed on
Autor:
Elisabeth D. Galsgaard, Henrik D. Pedersen, Berit Østergaard Christoffersen, Merete Fredholm, Markus Latta, Dorte Holst, Susanna Cirera
Publikováno v:
Journal of Clinical and Experimental Hepatology
Pedersen, H D, Galsgaard, E D, Christoffersen, B, Cirera, S, Holst, D, Fredholm, M & Latta, M 2020, ' NASH-inducing Diets in Göttingen Minipigs ', Journal of Clinical and Experimental Hepatology, vol. 10, no. 3, pp. 211-221 . https://doi.org/10.1016/j.jceh.2019.09.004
Pedersen, H D, Galsgaard, E D, Christoffersen, B, Cirera, S, Holst, D, Fredholm, M & Latta, M 2020, ' NASH-inducing Diets in Göttingen Minipigs ', Journal of Clinical and Experimental Hepatology, vol. 10, no. 3, pp. 211-221 . https://doi.org/10.1016/j.jceh.2019.09.004
Background Owing to the human-like physiology, a minipig model of nonalcoholic steatohepatitis (NASH) could be valuable. Pigs, however, rarely develop substantial hepatic steatosis, even when fed diets with high fat, fructose, and cholesterol (FFC) c
Autor:
Fredrik Wolfhagen Sand, Elisabeth D. Galsgaard, Sisse A Nørgaard, Henrik Søndergaard, Thierry Sulpice, Dorte Bratbo Sørensen, François Briand
Publikováno v:
European journal of pharmacology. 860
The widely used db/db mouse as a model of diabetic nephropathy (DN) only mimics the early changes in human DN with a slow disease progression. Since high protein diet (HPD) has been reported to affect progression of nephropathy in both humans and mic
Autor:
Morten Tonnesen, Martin Egfjord, Elisabeth D. Galsgaard, Peter Helding Kvist, Henrik Jeldtoft Jensen, Maria Elm Ougaard, Frederikke E. Sembach, Klaus Stensgaard Frederiksen
Publikováno v:
Nephron. 140(3)
Background/Aims: Murine nephrotoxic nephritis (NTN) is a well-established model resembling chronic kidney disease. Investigating gene expression patterns separately in the glomerular and cortical tubulointerstitial structure could provide new knowled