Daytime CLOCK Dephosphorylation Is Controlled by STRIPAK Complexes in Drosophila

Autor: Simonetta Andreazza, Sylvina Bouleau, Béatrice Martin, Annie Lamouroux, Prishila Ponien, Christian Papin, Elisabeth Chélot, Eric Jacquet, François Rouyer

Publikováno v: Cell Reports, Vol 11, Iss 8, Pp 1266-1279 (2015)

In the Drosophila circadian oscillator, the CLOCK/CYCLE complex activates transcription of period (per) and timeless (tim) in the evening. PER and TIM proteins then repress CLOCK (CLK) activity during the night. The pace of the oscillator depends upo

Externí odkaz: https://doaj.org/article/41b1847fd0bb404f958524873dbf5d11

PERIOD-controlled deadenylation of the timeless transcript in the Drosophila circadian clock

Autor: Eric Jacquet, Christian Papin, Prishila Ponien, Elisabeth Chélot, François Rouyer, Béatrice Martin, Brigitte Grima

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (12), pp.5721-5726. ⟨10.1073/pnas.1814418116⟩

Significance Circadian oscillators rely on transcriptional negative feedback loops. In Drosophila , the key transcriptional repressor PERIOD (PER) slowly accumulates during the night under the control of its partner TIMELESS (TIM). A large number of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38acccc1962b25b5234effd92def4be0
https://doi.org/10.1073/pnas.1814418116

Reconfiguration of a Multi-oscillator Network by Light in the Drosophila Circadian Clock

Autor: Wilson Mena, François Rouyer, Abhishek Chatterjee, Patrick Emery, Béatrice Martin, Angélique Lamaze, Elisabeth Chélot, Sebastian Kadener, Paul E. Hardin, Joydeep De

Publikováno v: Current Biology-CB
Current Biology-CB, Elsevier, 2018, ⟨10.1016/j.cub.2018.04.064⟩

International audience; The brain clock that drives circadian rhythms of locomotor activity relies on a multi-oscillator neuronal network. In addition to synchronizing the clock with day-night cycles, light also reformats the clock-driven daily activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc236dba413a7394a8466f20fdc979f
https://hal.archives-ouvertes.fr/hal-01828220

The F-box protein Slimb controls the levels of clock proteins Period and Timeless

Autor: Christian Papin, François Rouyer, Elisabeth Chélot, Annie Lamouroux, Brigitte Grima, Bernadette Limbourg-Bouchon

Publikováno v: Nature. 420:178-182

The Drosophila circadian clock is driven by daily fluctuations of the proteins Period and Timeless, which associate in a complex and negatively regulate the transcription of their own genes. Protein phosphorylation has a central role in this feedback

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4aa8937ecce926440c05bde2562997
https://doi.org/10.1038/nature01122

Cat proenkephalin-A does not contain the opioid octapeptide

Autor: Pascal Bochet, Michel Chaminade, Lia Prado de Carvalho, Elisabeth Chélot, Jean Rossier

Publikováno v: Neurochemistry International. 28:155-160

The sequence of a large cDNA fragment of proenkephalin-A from the cat adrenal medulla was obtained using reverse transcription followed by polymerase chain reaction, and cloning. This cDNA encompasses the region normally containing all the opioid pep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67269bf0a74b9f26c1f35aee85d0b2f0
https://doi.org/10.1016/0197-0186(95)00079-8