Výsledky vyhledávání - "Elisabeth Brabants"

Akademický článek

Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract Local delivery of mRNA-based immunotherapy offers a promising avenue as it enables the production of specific immunomodulatory proteins that can stimulate the immune system to recognize and eliminate cancer cells while limiting systemic expo

Externí odkaz: https://doaj.org/article/5d3d46521d37404983a65684b85cc442

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The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome

Autor: Celine Everaert, Hamida Hammad, Jo Vandesompele, Pieter Mestdagh, Kim Deswarte, Elisabeth Brabants, Nancy De Cabooter, Melissa Dullaers, Glenn Waegemans, Karim Vermaelen, Manon Vanheerswynghels, Bart N. Lambrecht, Lotte Pyfferoen, Kelly Heyns, Olivier De Wever, Sofie De Prijck

Publikováno v: OncoImmunology, 6(1):e1253655. Landes Bioscience
Oncoimmunology
ONCOIMMUNOLOGY

Targeting immunomodulatory pathways has ushered a new era in lung cancer therapy. Further progress requires deeper insights into the biology of immune cells in the lung cancer micro-environment. Dendritic cells (DCs) represent a heterogeneous and hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260c15e3808c8c53d36409a774aaf12c
https://pure.eur.nl/en/publications/685fcb28-9789-4b51-8f80-ef1fe6baa726

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Abstract A091: Specific myelomonocytic cells heavily infiltrate orthotopic lung tumors and display a hypoxia-driven miRNA expression signature that directs tumor-supporting functions and negatively impacts on clinical outcome

Autor: Karim Vermaelen, Elisabeth Brabants, Lotte Pyfferoen, Kim Deswarte, Bart N. Lambrecht, Nancy De Cabooter, Glenn Wagemans, Jo Vandesompele, Simon Tavernier, Hamida Hammad, Pieter Mestdagh, Olivier De Wever, Kelly Heyns, Celine Everaert

Publikováno v: Cancer Immunology Research. 4:A091-A091

Tumor-derived micro-RNA expression patterns are known to convey prognostic information in lung cancer. However, the cellular source of these signatures is unclear. In parallel, immunological parameters such as the presence and activation status of de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d077cb592668ef26983774e6c5cc6d93
https://doi.org/10.1158/2326-6066.imm2016-a091

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