Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Elisabeth Lorge"'
Autor:
Richard A. Spellman, David Kirkland, Véronique Thybaud, Melanie Guérard, Stephen D. Dertinger, Steven M. Bryce, Andreas Zeller, Jeffrey C. Bemis, Maik Schuler, Sabrina Wilde, Elisabeth Lorge, Andreas Sutter, Ulrike Hemmann, Nina Queisser, Pekka T. Heikkinen, Derek T. Bernacki, Maria Engel
Publikováno v:
Environmental and Molecular Mutagenesis. 58:146-161
We previously described a multiplexed in vitro genotoxicity assay based on flow cytometric analysis of detergent-liberated nuclei that are simultaneously stained with propidium iodide and labeled with fluorescent antibodies against p53, γH2AX, and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fada4cc49d4b86be27dafc87bb3b2f93
https://doi.org/10.1002/em.22083
https://doi.org/10.1002/em.22083
Autor:
Francesco Marchetti, Elisabeth Lorge, Dan D. Levy, Véronique Thybaud, Jan van Benthem, George R. Douglas, Rita Schoeny, Martha M. Moore
Publikováno v:
Environmental and Molecular Mutagenesis. 58:284-295
The Organization for Economic Cooperation and Development (OECD) recently revised the test guidelines (TGs) for genetic toxicology. This article describes the main issues addressed during the revision process, and the new and consistent recommendatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5bb766ba0379f9e98e3b5e282b751f9
https://doi.org/10.1002/em.22079
https://doi.org/10.1002/em.22079
Autor:
Jennifer Y. Tanir, Elisabeth Lorge, Mick D. Fellows, Véronique Thybaud, Masamitsu Honma, M.R. O'Donovan, B. Bhaskar Gollapudi, Marilyn J. Aardema, A. Kohara, Michael J. Armstrong, Sheila M. Galloway, Julie Clements, Martha M. Moore
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 809:1-15
Good cell culture practice and characterization of the cell lines used are of critical importance in in vitro genotoxicity testing. The objective of this initiative was to make continuously available stocks of the characterized isolates of the most f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328b3e383eae89ba4eae171365f9567f
Genotoxicity of tungsten carbide–cobalt (WC–Co) nanoparticles in vitro: Mechanisms-of-action studies
Publikováno v:
Mutation Research-Reviews
Mutation Research-Reviews, Elsevier, 2015, 779, pp.15-22. ⟨10.1016/j.mrgentox.2015.02.002⟩
Mutation Research-Reviews, 2015, 779, pp.15-22. ⟨10.1016/j.mrgentox.2015.02.002⟩
Mutation Research-Reviews, Elsevier, 2015, 779, pp.15-22. ⟨10.1016/j.mrgentox.2015.02.002⟩
Mutation Research-Reviews, 2015, 779, pp.15-22. ⟨10.1016/j.mrgentox.2015.02.002⟩
We showed previously that tungsten carbide–cobalt (WC–Co) nanoparticles (NP) can be used as a nanoparticulate positive control in some in vitro mammalian genotoxicity assays. Here, we investigate the mechanisms of action involved in WC–Co NP ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de62cfc004616e1e3a213ac835e9df5
https://doi.org/10.1016/j.mrgentox.2015.02.002
https://doi.org/10.1016/j.mrgentox.2015.02.002
Autor:
Steven M, Bryce, Derek T, Bernacki, Jeffrey C, Bemis, Richard A, Spellman, Maria E, Engel, Maik, Schuler, Elisabeth, Lorge, Pekka T, Heikkinen, Ulrike, Hemmann, Véronique, Thybaud, Sabrina, Wilde, Nina, Queisser, Andreas, Sutter, Andreas, Zeller, Melanie, Guérard, David, Kirkland, Stephen D, Dertinger
Publikováno v:
Environmental and molecular mutagenesis. 58(3)
We previously described a multiplexed in vitro genotoxicity assay based on flow cytometric analysis of detergent-liberated nuclei that are simultaneously stained with propidium iodide and labeled with fluorescent antibodies against p53, γH2AX, and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a6da3ae56952612a2a0f889c16b31da
https://pubmed.ncbi.nlm.nih.gov/28370322
https://pubmed.ncbi.nlm.nih.gov/28370322
Autor:
Veronique, Thybaud, Elisabeth, Lorge, Dan D, Levy, Jan, van Benthem, George R, Douglas, Francesco, Marchetti, Martha M, Moore, Rita, Schoeny
Publikováno v:
Environmental and molecular mutagenesis. 58(5)
The Organization for Economic Cooperation and Development (OECD) recently revised the test guidelines (TGs) for genetic toxicology. This article describes the main issues addressed during the revision process, and the new and consistent recommendatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::acd0ed987a62c9504948b0fb2d9b2fba
https://pubmed.ncbi.nlm.nih.gov/28266061
https://pubmed.ncbi.nlm.nih.gov/28266061
Autor:
Dan D. Levy, Mick D. Fellows, Marilyn J. Aardema, Takeshi Morita, Robert H. Heflich, Elisabeth Lorge, David Kirkland, Maik Schuler, Anthony M. Lynch, Daniel Marzin, David A. Eastmond, Günter Speit, Sheila M. Galloway
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 723:77-83
The selection of maximum concentrations for in vitro mammalian cell genotoxicity assays was reviewed at the 5th International Workshop on Genotoxicity Testing (IWGT), 2009. Currently, the top concentration recommended when toxicity is not limiting is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e935bb8d6d6e649e4fd803ab3b13be45
https://doi.org/10.1016/j.mrgentox.2011.01.003
https://doi.org/10.1016/j.mrgentox.2011.01.003
Autor:
Willi Suter, Kristine L. Witt, Elisabeth Lorge, Véronique Thybaud, Dan D. Levy, Kerry L. Dearfield, Gladys Ouedraogo-Arras, Kirk S. Tarlo, Laura Custer, James Harvey, James H. Kim, Michael C. Cimino, Susan D. Hester, David Kirkland, Maik Schuler, Freddy Van Goethem, Martha M. Moore, Kevin Sweder, Andreas Czich, Jan van Benthem
Publikováno v:
Environmental and Molecular Mutagenesis. 52:177-204
Appropriate follow-up actions and decisions are needed when evaluating and interpreting clear positive results obtained in the in vitro assays used in the initial genotoxicity screening battery (i.e., the battery of tests generally required by regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63ae4d2b7d7d4a81d32d1609a101535
https://doi.org/10.1002/em.20617
https://doi.org/10.1002/em.20617
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 655:4-21
Appropriate measures of cytotoxicity need to be used when selecting test concentrations in in vitro genotoxicity assays. Underestimation of toxicity may lead to inappropriately toxic concentrations being selected for analysis, with the potential for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f914ae14fbfb3ff92674cd28960b3192
https://doi.org/10.1016/j.mrgentox.2008.06.004
https://doi.org/10.1016/j.mrgentox.2008.06.004
Autor:
Véronique Gervais, Nancy Claude, Catherine Maisonneuve, Nathalie Becourt-Lhote, Jean-Luc Delongeas, Elisabeth Lorge
Publikováno v:
Toxicological Sciences. 98:39-42
The minimal three-test battery of the International Conference on Harmonization guideline has been in use since 1997 for the development of new pharmaceuticals (ICH, 1997). After a 10-year experience of this core battery in regulatory genotoxicity te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b6bc6250bb053c78971744b55e5062
https://doi.org/10.1093/toxsci/kfm056
https://doi.org/10.1093/toxsci/kfm056