Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Elisabeth, Bosch"'
Autor:
Elisabeth Bosch, Bernt Popp, Esther Güse, Cindy Skinner, Pleuntje J. van der Sluijs, Isabelle Maystadt, Anna Maria Pinto, Alessandra Renieri, Lucia Pia Bruno, Stefania Granata, Carlo Marcelis, Özlem Baysal, Dewi Hartwich, Laura Holthöfer, Bertrand Isidor, Benjamin Cogne, Dagmar Wieczorek, Valeria Capra, Marcello Scala, Patrizia De Marco, Marzia Ognibene, Rami Abou Jamra, Konrad Platzer, Lauren B. Carter, Outi Kuismin, Arie van Haeringen, Reza Maroofian, Irene Valenzuela, Ivon Cuscò, Julian A. Martinez-Agosto, Ahna M. Rabani, Heather C. Mefford, Elaine M. Pereira, Charlotte Close, Kwame Anyane-Yeboa, Mallory Wagner, Mark C. Hannibal, Pia Zacher, Isabelle Thiffault, Gea Beunders, Muhammad Umair, Priya T. Bhola, Erin McGinnis, John Millichap, Jiddeke M van de Kamp, Eloise J. Prijoles, Amy Dobson, Amelle Shillington, Brett H. Graham, Evan-Jacob Garcia, Maureen Kelly Galindo, Fabienne G. Ropers, Esther AR Nibbeling, Gail Hubbard, Catherine Karimov, Guido Goj, Renee Bend, Julie Rath, Michelle M Morrow, Francisca Millan, Vincenzo Salpietro, Annalaura Torella, Vincenzo Nigro, Mitja Kurki, Roger E Stevenson, Gijs W.E. Santen, Markus Zweier, Philippe M. Campeau, Mariasavina Severino, André Reis, Andrea Accogli, Georgia Vasileiou
PURPOSECoffin-Siris and Nicolaides-Baraitser syndromes, are recognisable neurodevelopmental disorders caused by germline variants in BAF complex subunits. TheSMARCC2BAFopathy was recently reported. Herein, we present clinical and molecular data on a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c27085d1605a13771b0976056173917e
https://doi.org/10.1101/2023.03.30.23287962
https://doi.org/10.1101/2023.03.30.23287962
Autor:
Alex Avdeef, Elisabet Fuguet, Antonio Llinàs, Clara Ràfols, Elisabeth Bosch, Gergely Völgyi, Tatjana Verbić, Elena Boldyreva, Krisztina Takács-Novák
Publikováno v:
ADMET and DMPK, Vol 4, Iss 2, Pp 117-178 (2016)
This commentary addresses data quality in equilibrium solubility measurement in aqueous solution. Broadly discussed is the “gold standard” shake-flask (SF) method used to measure equilibrium solubility of ionizable drug-like molecules as a functi
Externí odkaz:
https://doaj.org/article/cf95436527154eea96006f47bb2785dd
Publikováno v:
ADMET and DMPK, Vol 2, Iss 2, Pp 107-114 (2014)
Predictive software packages to estimate the lipophilicity of molecules have become key tools in the new drug design. Six different well-known computational programs including the classical BioByte-clogP and the GALAS algorithm offered by ACDlabs wer
Externí odkaz:
https://doaj.org/article/72c4da83711b4f8eb0c12ca907bd1730
Publikováno v:
SSRN Electronic Journal.
Acidity constants (pKa) of nine flavonoids have been spectrophotometrically determined and the obtained values carefully contrasted with those derived from various experimental approaches given in literature, as well as with the ones predicted by Per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04798a1b414354ff2d5f449fcbe70b92
https://doi.org/10.2139/ssrn.4219585
https://doi.org/10.2139/ssrn.4219585
Autor:
William G. Wilson, Arif B. Ekici, Helen Cox, Bernt Popp, Shagufta Khan, Bettina Behring, Moritz Hebebrand, Regina Trollmann, André Reis, Theresa Penger, Steffen Uebe, Cornelia Kraus, Joachim Woelfle, Mandy Krumbiegel, Georgia Vasileiou, Shelley Towner, Elisabeth Bosch
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism.
Context CPE encodes carboxypeptidase E, an enzyme that converts proneuropeptides and propeptide hormones to bioactive forms. It is widely expressed in the endocrine and central nervous system. To date, 4 individuals from 2 families with core clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb8d04d2563be5f9553065bca7cbe27
https://doi.org/10.1210/clinem/dgab592
https://doi.org/10.1210/clinem/dgab592
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
It is widely accepted that solubility-pH profiles of ionizable compounds follow the Henderson-Hasselbalch equation. However, several studies point out that compounds often undergo additional processes in saturated solutions, such as sub-micellar olig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ad9a522ed578617d6ab4b83a55cadf
http://hdl.handle.net/2445/178187
http://hdl.handle.net/2445/178187
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
A wide set of well-known drugs, most of them included in the Abraham´s reference database, covering a wide variety of chemical structures and therapeutical functionalities were chosen in order to determine some molecular properties from solvent/wate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6fee1632569e68a746dc76db3ae0050
https://doi.org/10.1016/j.ejps.2021.106066
https://doi.org/10.1016/j.ejps.2021.106066
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Interaction thermodynamics between warfarin, a very popular anticoagulant, and Sudlow I binding site of human (HSA) or bovine (BSA) serum albumin have been examined in strictly controlled experimental conditions (HEPES buffer 50 mM, pH 7.4 and 25 °C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd169ca64c6682605cf6ce9281dd2dd0
https://doi.org/10.1016/j.jpba.2017.12.008
https://doi.org/10.1016/j.jpba.2017.12.008
Autor:
Xavier Subirats, Martí Rosés, Magda Bordas, Adriana Port, Elisabeth Bosch, Rosalia Pascual, Clara Ràfols, Raquel Enrech
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
instname
Dipòsit Digital de la UB
Universidad de Barcelona
In the present study three different procedures have been compared for the determination of the lipophilicity of the unionized species (log Po/w) of neutral, acidic, basic, amphoteric, and zwitterionic drugs. Shake-flask, potentiometric and chromatog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1fbbe378ff685f42bbb53624f638ce
http://hdl.handle.net/2445/127667
http://hdl.handle.net/2445/127667
Autor:
Adriana, Port, Magda, Bordas, Raquel, Enrech, Rosalia, Pascual, Martí, Rosés, Clara, Ràfols, Xavier, Subirats, Elisabeth, Bosch
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 122
In the present study three different procedures have been compared for the determination of the lipophilicity of the unionized species (log P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::813e4229bcd27967ff025f020bd5be84
https://pubmed.ncbi.nlm.nih.gov/30006180
https://pubmed.ncbi.nlm.nih.gov/30006180