New approach methodologies in human regulatory toxicology – Not if, but how and when!

Autor: Sebastian Schmeisser, Andrea Miccoli, Martin von Bergen, Elisabet Berggren, Albert Braeuning, Wibke Busch, Christian Desaintes, Anne Gourmelon, Roland Grafström, Joshua Harrill, Thomas Hartung, Matthias Herzler, George E.N. Kass, Nicole Kleinstreuer, Marcel Leist, Mirjam Luijten, Philip Marx-Stoelting, Oliver Poetz, Bennard van Ravenzwaay, Rob Roggeband, Vera Rogiers, Adrian Roth, Pascal Sanders, Russell S. Thomas, Anne Marie Vinggaard, Mathieu Vinken, Bob van de Water, Andreas Luch, Tewes Tralau

Publikováno v: Environment International, Vol 178, Iss , Pp 108082- (2023)

The predominantly animal-centric approach of chemical safety assessment has increasingly come under pressure. Society is questioning overall performance, sustainability, continued relevance for human health risk assessment and ethics of this system,

Externí odkaz: https://doaj.org/article/f976f541aefc4b4e8d0e30fa3b873d98

Current EU regulatory requirements for the assessment of chemicals and cosmetic products: challenges and opportunities for introducing new approach methodologies

Autor: Valérie Zuang, Alicia Paini, Stephanie K. Bopp, Pilar Prieto, Elisabet Berggren, Silvia Casati, Andrew Worth, Sharon Munn, Elise Grignard, Anna Bal-Price, Federica Madia, Francesca Pistollato, Raffaella Corvi

Publikováno v: Archives of Toxicology

The EU Directive 2010/63/EU on the protection of animals used for scientific purposes and other EU regulations, such as REACH and the Cosmetic Products Regulation advocate for a change in the way toxicity testing is conducted. Whilst the Cosmetic Pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eddf50d34b4b749ed88d1ebabeae6e11
https://doi.org/10.1007/s00204-021-03034-y

21st Century Approaches for Evaluating Exposures, Biological Activity, and Risks of Complex Substances:Workshop highlights

Autor: Kathleen P. Plotzke, Bruno Hubesch, Elisabet Berggren, Robert A. Barter, Océane Albert, Emilio Benfenati, Heli M. Hollnagel, Ursula G. Sauer, Kunifumi Inawaka, Philipp Mayer, Robert Skoglund, Richard A. Becker, Athena M. Keene

Publikováno v: Sauer, U G, Barter, R A, Becker, R A, Benfenati, E, Berggren, E, Hubesch, B, Hollnagel, H M, Inawaka, K, Keene, A M, Mayer, P, Plotzke, K, Skoglund, R & Albert, O 2020, ' 21 st Century Approaches for Evaluating Exposures, Biological Activity, and Risks of Complex Substances : Workshop highlights ', Regulatory Toxicology and Pharmacology, vol. 111, 104583 . https://doi.org/10.1016/j.yrtph.2020.104583

The June 2019 workshop 21st Century Approaches for Evaluating Exposures, Biological Activity, and Risks of Complex Substances, co-organised by the International Council of Chemical Association's Long-Range Research Initiative and the European Commiss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb202031e6a43a386f6ee6a14d8c93b6
https://orbit.dtu.dk/en/publications/e7fb96f5-968d-4d29-a7af-200847cff86b

The virtual cell based assay: Current status and future perspectives

Autor: Andrew Worth, Maurice Whelan, David Asturiol, Elisabet Berggren, Lara Lamon, Rabea Graepel, Alicia Paini, Elisabeth Joossens, Pilar Prieto

Publikováno v: Toxicology in Vitro

In order to replace the use of animals in toxicity testing, there is a need to predict in vivo toxic doses from concentrations that cause toxicological effects in relevant in vitro systems. The Virtual Cell Based Assay (VCBA) estimates time-dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f2512c15bfdef6478b8b8fa3c0749f
https://doi.org/10.1016/j.tiv.2017.01.009

Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making

Autor: Patric Amcoff, Michael Schwarz, Hubert Deluyker, Julien Burton, Terry W Schultz, Andrew Worth, Mark T. D. Cronin, Alfonso Lostia, Andrew White, Romualdo Benigni, Edward W. Carney, Ivan Rusyn, Elisabet Berggren, Gerrit Schüürmann, Georges E. N. Kass, Karen Blackburn, Richard S. Judson, Francoise Gautier, Derek Knight, Sharon Munn, Catherine Mahony, Werner Lilienblum, Detlef Keller

Publikováno v: Environmental Health Perspectives

Background Safety assessment for repeated dose toxicity is one of the largest challenges in the process to replace animal testing. This is also one of the proof of concept ambitions of SEURAT-1, the largest ever European Union research initiative on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b990286a6500180b60b4df8d8c5c228
https://doi.org/10.1289/ehp.1409342