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Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2503-2506
A short synthesis of 3-N-substituted-4,5-bis(3-indolyl)oxazol-2-ones is described from bis(3-indolyl)glyoxal. Their in vitro antimicrobial activities against different strains of microorganisms are examined.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4668c0825c115c49ac5c3877a50fc7bd
https://doi.org/10.1016/s0960-894x(97)10007-5
https://doi.org/10.1016/s0960-894x(97)10007-5
Autor:
Anne-Marie Martre, Valérie Spessel, Guy Mousset, Elisabète Rodrigues Pereira, Michelle Prudhomme
Publikováno v:
Tetrahedron Letters. 36:2479-2482
The synthesis of 4-(3-indolyl)-oxazol-2-one including two electrochemical pathways is described. This compound, possessing both indole and oxazol-2-one moieties is expected to be an efficient protein kinase C inhibitor and to exhibit a vasorelaxant e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a5d067764c61a9f7dadcb9a6f404564
https://doi.org/10.1016/0040-4039(95)00287-1
https://doi.org/10.1016/0040-4039(95)00287-1
Publikováno v:
The Journal of Antibiotics. 48:863-868
New compounds, structurally related to the potent protein kinase C inhibitor staurosporine, and substituted on the imide nitrogen with a functional group bearing a labile hydrogen (hydroxymethyl, amino, hydroxy), were synthesized. Their in vitro inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa4dfe67cbcf34ce9c1fbdab5995501
https://doi.org/10.7164/antibiotics.48.863
https://doi.org/10.7164/antibiotics.48.863
Autor:
Claude Houssier, Jean-François Riou, Michelle Prudhomme, Christian Bailly, Elisabète Rodrigues-Pereira, Pierre Colson
Publikováno v:
Biochemistry. 36(13)
DNA topoisomerase I has been shown to be an important therapeutic target in cancer chemotherapy for the camptothecins as well as for indolocarbazole antibiotics such as BE-13793C and its synthetic derivatives NB-506 and ED-110 [Yoshinari et al. (1993
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40311ceb8e769b20abe30c6a032ae68e
https://pubmed.ncbi.nlm.nih.gov/9092822
https://pubmed.ncbi.nlm.nih.gov/9092822
Autor:
Jean Pierre Savineau, Jean-François Riou, Monique Ollier, Danièle Sevère, Michelle Prudhomme, Elisabète Rodrigues Pereira, Thomas Meyer, Henri Crevel, Doriano Fabbro, Martine Sancelme
Publikováno v:
Chemicalpharmaceutical bulletin. 45(4)
Eight compounds structurally related to protein kinase C inhibitor MDL 27032 and substituted with indole moieties were synthesized. Their activities towards protein kinase C (PKC) and protein kinase A (PKA) were determined. Their effect on PKC-mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6010a9d0c601f9173ba86a99bba5b8f1
https://pubmed.ncbi.nlm.nih.gov/9145508
https://pubmed.ncbi.nlm.nih.gov/9145508
Autor:
Thomas Meyer, Doriano Fabbro, Jean-François Riou, Michelle Prudhomme, Martine Sancelme, Elisabète Rodrigues Pereira, Laure Belin, Monique Ollier, Danièle Sevère, Rapp Maryse
Publikováno v:
Journal of medicinal chemistry. 39(22)
A series of compounds structurally related to staurosporine, rebeccamycin, and corresponding aglycones was synthesized, and their activities toward protein kinase C and topoisomerases I and II were tested together with their in vitro antitumor effici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7866d1e84610cd790ebce84a4c258af5
https://pubmed.ncbi.nlm.nih.gov/8893841
https://pubmed.ncbi.nlm.nih.gov/8893841
Publikováno v:
Tetrahedron Letters. 36:2477-2478
A short route to an analogue of protein kinase C inhibitor K252c possessing an oxazol-2-one heterocycle instead of a maleamide one is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3ee32a6eb489abbe07d5bb9979cc2df
https://doi.org/10.1016/0040-4039(95)94696-p
https://doi.org/10.1016/0040-4039(95)94696-p