Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Elisa Vergari"'
Autor:
Elisa Vergari, Jakob G. Knudsen, Reshma Ramracheya, Albert Salehi, Quan Zhang, Julie Adam, Ingrid Wernstedt Asterholm, Anna Benrick, Linford J. B. Briant, Margarita V. Chibalina, Fiona M. Gribble, Alexander Hamilton, Benoit Hastoy, Frank Reimann, Nils J. G. Rorsman, Ioannis I. Spiliotis, Andrei Tarasov, Yanling Wu, Frances M. Ashcroft, Patrik Rorsman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Impaired glucagon secretion in patients with diabetes causes hypoglycemia. Here the authors show that therapeutic concentrations of insulin inhibit alpha-cell glucagon secretion by stimulating delta-cell insulin receptor and the release of somatostat
Externí odkaz:
https://doaj.org/article/9d4aeee6ff1d49cdae2f6687f5fe8637
Publikováno v:
Biomolecules, Vol 2, Iss 2, Pp 269-281 (2012)
The secretion of insulin by pancreatic islet β-cells plays a pivotal role in glucose homeostasis and diabetes. Recent work suggests an important role for SUMOylation in the control of insulin secretion from β-cells. In this paper we discuss mechani
Externí odkaz:
https://doaj.org/article/99c788efdf8f4d39a1fca2ac3a225b32
Publikováno v:
Peptides. 147
The pancreatic islets contain beta-cells and alpha-cells, which are responsible for secreting two principal gluco-regulatory hormones; insulin and glucagon, respectively. However, they also contain delta-cells, a relatively sparse cell type that secr
Autor:
Elisa, Vergari, Geoffrey, Denwood, Albert, Salehi, Quan, Zhang, Julie, Adam, Ahmed, Alrifaiy, Ingrid, Wernstedt Asterholm, Anna, Benrick, Margarita V, Chibalina, Lena, Eliasson, Claudia, Guida, Thomas G, Hill, Alexander, Hamilton, Reshma, Ramracheya, Frank, Reimann, Nils J G, Rorsman, Ioannis, Spilliotis, Andrei I, Tarasov, Jonathan N, Walker, Patrik, Rorsman, Linford J B, Briant
Publikováno v:
Nature metabolism
Pancreatic islets are complex micro-organs consisting of at least three different cell types: glucagon-secreting α-, insulin-producing β- and somatostatin-releasing δ-cells1. Somatostatin is a powerful paracrine inhibitor of insulin and glucagon s
Publikováno v:
Journal of Visualized Experiments.
Pancreatic islet hormones regulate blood glucose homeostasis. Changes in blood glucose induce oscillations of cytosolic calcium in pancreatic islet cells that trigger secretion of three main hormones: insulin (from β-cells), glucagon (α-cells) and
Publikováno v:
Journal of Histochemistry & Cytochemistry. 63:575-591
Islet non-β-cells, the α- δ- and pancreatic polypeptide cells (PP-cells), are important components of islet architecture and intercellular communication. In α-cells, glucagon is found in electron-dense granules; granule exocytosis is calcium-depe
Autor:
Dan Li, Lavinia Woodward, David J. Paterson, Chieh-Ju Lu, Nicoletta C. Surdo, Neil Herring, Elisa Vergari, Guoliang Hao, Hannah Wright, Manuela Zaccolo, Kun Liu
Publikováno v:
Hypertension. 66:190-198
Elevated B-type natriuretic peptide (BNP) regulates cGMP-phosphodiesterase activity. Its elevation is regarded as an early compensatory response to cardiac failure where it can facilitate sympathovagal balance and cardiorenal homeostasis. However, re
Publikováno v:
Journal of The Royal Society Interface
Autor:
Linford J B, Briant, Quan, Zhang, Elisa, Vergari, Joely A, Kellard, Blanca, Rodriguez, Frances M, Ashcroft, Patrik, Rorsman
Publikováno v:
Journal of the Royal Society Interface
The α-, β- and δ-cells of the pancreatic islet exhibit different electrophysiological features. We used a large dataset of whole-cell patch-clamp recordings from cells in intact mouse islets (N = 288 recordings) to investigate whether it is possib
Autor:
Makoto Shigeto, Manuela Zaccolo, Reshma Ramracheya, Antony Galione, William Sones, Thomas Reinbothe, Benoit Hastoy, Rudi Vennekens, Elisa Vergari, Cathryn Weston, Graham Ladds, Viacheslav O. Nikolaev, Chae Young Cha, Masashi Katsura, Nils J.G. Rorsman, Andrei I. Tarasov, Patrik Rorsman, Paul Johnson, Julia Gorelik, Koenraad Philippaert, Margarita V. Chibalina, Albert Salehi, Kohei Kaku
Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); however, it is not clear whether GLP-1 directly drives insulin secretio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce9c8d589f091227aa5ae7d0286bf35
https://ora.ox.ac.uk/objects/uuid:bf20aef5-debd-4768-9a1e-76c25351ea79
https://ora.ox.ac.uk/objects/uuid:bf20aef5-debd-4768-9a1e-76c25351ea79