Ethanol exposure increases mutation rate through error-prone polymerases

Autor: Karin Voordeckers, Camilla Colding, Lavinia Grasso, Benjamin Pardo, Lore Hoes, Jacek Kominek, Kim Gielens, Kaat Dekoster, Jonathan Gordon, Elisa Van der Zande, Peter Bircham, Toon Swings, Jan Michiels, Peter Van Loo, Sandra Nuyts, Philippe Pasero, Michael Lisby, Kevin J. Verstrepen

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Whereas the toxic effects of ethanol are well-documented, the underlying mechanism is obscure. This study uses the eukaryotic model S. cerevisiae to reveal how exposure to sublethal ethanol concentrations causes DNA replication stress and an increase

Externí odkaz: https://doaj.org/article/df587fed078742dfbc9ad32716f400df

Adaptation to High Ethanol Reveals Complex Evolutionary Pathways.

Autor: Karin Voordeckers, Jacek Kominek, Anupam Das, Adriana Espinosa-Cantú, Dries De Maeyer, Ahmed Arslan, Michiel Van Pee, Elisa van der Zande, Wim Meert, Yudi Yang, Bo Zhu, Kathleen Marchal, Alexander DeLuna, Vera Van Noort, Rob Jelier, Kevin J Verstrepen

Publikováno v: PLoS Genetics, Vol 11, Iss 11, p e1005635 (2015)

Tolerance to high levels of ethanol is an ecologically and industrially relevant phenotype of microbes, but the molecular mechanisms underlying this complex trait remain largely unknown. Here, we use long-term experimental evolution of isogenic yeast

Externí odkaz: https://doaj.org/article/81888a5e063e499fb9e2508c82055ffd

Ethanol exposure increases mutation rate through error-prone polymerases

Autor: Michael Lisby, Peter W. Bircham, Toon Swings, Benjamin Pardo, Jacek Kominek, Lavinia Grasso, Lore Hoes, Elisa van der Zande, Jan Michiels, Karin Voordeckers, Camilla Colding, Sandra Nuyts, Philippe Pasero, Jonathan L Gordon, Kevin J. Verstrepen, Kim Gielens, Kaat Dekoster, Peter Van Loo

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-17447-3⟩
Voordeckers, K, Colding, C, Grasso, L, Pardo, B, Hoes, L, Kominek, J, Gielens, K, Dekoster, K, Gordon, J, Van der Zande, E, Bircham, P, Swings, T, Michiels, J, Van Loo, P, Nuyts, S, Pasero, P, Lisby, M & Verstrepen, K J 2020, ' Ethanol exposure increases mutation rate through error-prone polymerases ', Nature Communications, vol. 11, 3664 . https://doi.org/10.1038/s41467-020-17447-3

Ethanol is a ubiquitous environmental stressor that is toxic to all lifeforms. Here, we use the model eukaryote Saccharomyces cerevisiae to show that exposure to sublethal ethanol concentrations causes DNA replication stress and an increased mutation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7076704eb8bc67eeab2a3d75f0d1a9ed
http://link.springer.com/article/10.1038/s41467-020-17447-3

Selecting and generating superior yeasts for the brewing industry

Autor: Wim Meert, Elham Aslankoohi, Elisa van der Zande, Joaquin F. Christiaens, Karin Voordeckers, Esther Meersman, Veerle Saels, Kevin J. Verstrepen, Rita Gemayel, Aaron M. New, Tim Snoek, Martina Picca Nicolino, Jan Steensels, Ksenia Pougach

Publikováno v: Cerevisia. 37:63-67

Fermented foods and beverages have been consumed by umans for over 8000 years. These fermentations were at first spontaneous process, without any control or knowledge of the icrobial driving force. This led to irregular and often inferior end roducts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cea92968e35e9adb7dcbe03c5e431777
https://doi.org/10.1016/j.cervis.2012.08.001

Nucleosomes affect local transformation efficiency

Autor: Karin Voordeckers, Elham Aslankoohi, Kathleen Marchal, Elisa van der Zande, Hong Sun, Kevin J. Verstrepen, Aminael Sánchez-Rodríguez

Publikováno v: Nucleic Acids Research
NUCLEIC ACIDS RESEARCH

Genetic transformation is a natural process during which foreign DNA enters a cell and integrates into the genome. Apart from its relevance for horizontal gene transfer in nature, transformation is also the cornerstone of today's recombinant gene tec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0de391dd6580a2adcbd8c7ca7c79cae
https://pubmed.ncbi.nlm.nih.gov/22904077