Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Elisa Uliassi"'
Autor:
Elisa Uliassi, Clara M. Lima, Michael G. Bertram, Eli S.J. Thoré, Anabela Cordeiro da Silva, Luis Cardoso, Harry P. de Koning, Maria Paola Costi
Publikováno v:
Open Research Europe, Vol 4 (2024)
Background The current scientific discourse on environmental impacts of veterinary medicines mostly focuses on ectoparasiticides. Meanwhile, the environmental impacts of widely prescribed drugs for the treatment of human and animal parasitic vector-b
Externí odkaz:
https://doaj.org/article/79a6adb786da4bceb5de05bfc8cca376
Autor:
Maria da Conceição Avelino Dias Bianco, Debora Inacio Leite, Frederico Silva Castelo Branco, Nubia Boechat, Elisa Uliassi, Maria Laura Bolognesi, Monica Macedo Bastos
Publikováno v:
Molecules, Vol 27, Iss 23, p 8502 (2022)
The concept of polypharmacology embraces multiple drugs combined in a therapeutic regimen (drug combination or cocktail), fixed dose combinations (FDCs), and a single drug that binds to different targets (multi-target drug). A polypharmacology approa
Externí odkaz:
https://doaj.org/article/a438763d480e43939f97e435e55d3f3e
Autor:
Angela Lauriola, Elisa Uliassi, Matteo Santucci, Maria Laura Bolognesi, Marco Mor, Laura Scalvini, Gian Marco Elisi, Gaia Gozzi, Lorenzo Tagliazucchi, Gaetano Marverti, Stefania Ferrari, Lorena Losi, Domenico D’Arca, Maria Paola Costi
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 391 (2022)
The transcriptional regulators YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif) are the major downstream effectors in the Hippo pathway and are involved in cancer progression through modulation of the activit
Externí odkaz:
https://doaj.org/article/6b37af2ad3704c51b856208309d6c8c9
Autor:
Rona R. Ramsay, Marija R. Popovic-Nikolic, Katarina Nikolic, Elisa Uliassi, Maria Laura Bolognesi
Publikováno v:
Clinical and Translational Medicine, Vol 7, Iss 1, Pp 1-14 (2018)
Abstract Diseases of infection, of neurodegeneration (such as Alzheimer’s and Parkinson’s diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identify potential modulators for m
Externí odkaz:
https://doaj.org/article/f64c404e4da0439c8233adec1796bb0a
Autor:
Elisa Uliassi, Andressa Souza de Oliveira, Luciana de Camargo Nascente, Luiz Antonio Soares Romeiro, Maria Laura Bolognesi
Publikováno v:
Molecules, Vol 26, Iss 18, p 5441 (2021)
Alzheimer’s disease (AD) is a complex neurodegenerative disorder with a multifaceted pathogenesis. This fact has long halted the development of effective anti-AD drugs. Recently, a therapeutic strategy based on the exploitation of Brazilian biodive
Externí odkaz:
https://doaj.org/article/4c678febf0dd4d9d828d3c33fa6c9fdb
Autor:
Elisa Uliassi, Lorna Piazzi, Federica Belluti, Marcel Kaiser, Reto Brun, Sheraz Gul, Bernhard Ellinger, Carolina B. Moraes, Lucio H. Freitas-Junior, Chiara Borsari, Maria Paola Costi, Maria Laura Bolognesi
Publikováno v:
Proceedings, Vol 1, Iss 6, p 648 (2017)
Protozoan infections (Plasmodium spp., Leishmania spp., and Trypanosoma spp.) remain one of the most pressing global health concerns, affecting billions of people and producing unsustainable economic burdens [1]. [...]
Externí odkaz:
https://doaj.org/article/f3f63b03c20b45e7b13e2df14fd7d599
Autor:
Rocío Marisol Espinoza-Chávez, Alessandra Salerno, Anastasia Liuzzi, Andrea Ilari, Andrea Milelli, Elisa Uliassi, Maria Laura Bolognesi
Publikováno v:
ACS Bio & Med Chem Au. 3:32-45
Targeted protein degradation (TPD) is emerging as one of the most innovative strategies to tackle infectious diseases. Particularly, proteolysis-targeting chimera (PROTAC)-mediated protein degradation may offer several benefits over classical anti-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e553f9eff40b3a827a42afd0b8519c
https://doi.org/10.1021/acsbiomedchemau.2c00063
https://doi.org/10.1021/acsbiomedchemau.2c00063
Autor:
Melissa Guardigni, Letizia Pruccoli, Alan Santini, Angela De Simone, Matteo Bersani, Francesca Spyrakis, Flavia Frabetti, Elisa Uliassi, Vincenza Andrisano, Barbara Pagliarani, Paula Fernández-Gómez, Valle Palomo, Maria Laura Bolognesi, Andrea Tarozzi, Andrea Milelli
Publikováno v:
ACS Chemical Neuroscience.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be63e20b0db36b959f8e8c80a3d4ca13
https://doi.org/10.1021/acschemneuro.3c00096
https://doi.org/10.1021/acschemneuro.3c00096
Autor:
Elisa Uliassi, Flaminia Di Pietri, Ondrej Soukup, Manuela Bartolini, Claudia Albertini, Anna Tramarin, Lenka Pulkrabkova, Maria Laura Bolognesi, Sabrina Petralla, Rosaria Carmela Perone, Nicola Rizzardi, Romana Fato, Pedro de Sena Murteira Pinheiro
Publikováno v:
ChemMedChem. 16:187-198
Thanks to the widespread use and safety profile of donepezil (1) in the treatment of Alzheimer's disease (AD), one of the most widely adopted multi-target-directed ligand (MTDL) design strategies is to modify its molecular structure by linking a seco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1485fc5d25dca0b7c46d0c7398c7b08
https://doi.org/10.1002/cmdc.202000484
https://doi.org/10.1002/cmdc.202000484
Autor:
Claudia Albertini, Alessandra Salerno, Silvia Atzeni, Elisa Uliassi, Francesca Massenzio, Annalisa Maruca, Roberta Rocca, Marko Mecava, Filomena S. G. Silva, Débora Mena, Pedro Valente, Ana I. Duarte, Daniel Chavarria, Maicol Bissaro, Stefano Moro, Stephanie Federico, Giampiero Spalluto, Ondřej Soukup, Fernanda Borges, Stefano Alcaro, Barbara Monti, Paulo J. Oliveira, Josè C. Menéndez, Maria Laura Bolognesi
Polypharmacology is a new trend in amyotrophic lateral sclerosis (ALS) therapy and an effective way of addressing a multifactorial etiology involving excitotoxicity, mitochondrial dysfunction, oxidative stress, and microglial activation. Inspired by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8898ca7bb004e27e5695c334f1ae5ab1
https://hdl.handle.net/11585/894854
https://hdl.handle.net/11585/894854
