Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Elisa Theresa Helbig"'
Autor:
Joanna C Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny, Rebecca Evans, Mia I Temkin, Nathalia De Vasconcelos, Iker Valle Aramburu, Dennis Hoving, Donna Basire, Tracey Crissell, Jesusa Guinto, Alison Webb, Hanif Esmail, Victoria Johnston, Anna Last, Thomas Rampling, Lena Lippert, Elisa Theresa Helbig, Florian Kurth, Bryan Williams, Aiden Flynn, Pauline T Lukey, Veronique Birault, Venizelos Papayannopoulos
Publikováno v:
eLife, Vol 12 (2024)
Background: Prinflammatory extracellular chromatin from neutrophil extracellular traps (NETs) and other cellular sources is found in COVID-19 patients and may promote pathology. We determined whether pulmonary administration of the endonuclease dorna
Externí odkaz:
https://doaj.org/article/aa0642bdfc68412890699c84f062b563
Autor:
Ziyue Wang, Adam Cryar, Oliver Lemke, Pinkus Tober-Lau, Daniela Ludwig, Elisa Theresa Helbig, Stefan Hippenstiel, Leif-Erik Sander, Daniel Blake, Catherine S. Lane, Rebekah L. Sayers, Christoph Mueller, Johannes Zeiser, StJohn Townsend, Vadim Demichev, Michael Mülleder, Florian Kurth, Ernestas Sirka, Johannes Hartl, Markus Ralser
Publikováno v:
EClinicalMedicine, Vol 49, Iss , Pp 101495- (2022)
Summary: Background: Global healthcare systems continue to be challenged by the COVID-19 pandemic, and there is a need for clinical assays that can help optimise resource allocation, support treatment decisions, and accelerate the development and eva
Externí odkaz:
https://doaj.org/article/aadb73eb13a34f0391026389c47c46a0
Autor:
Iker Valle Aramburu, Dennis Hoving, Spyros I. Vernardis, Martha C.F. Tin, Marianna Ioannou, Mia I. Temkin, Nathalia M. De Vasconcelos, Vadim Demichev, Elisa Theresa Helbig, Lena Lippert, Klaus Stahl, Matthew White, Helena Radbruch, Jana Ihlow, David Horst, Scott T. Chiesa, John E. Deanfield, Sascha David, Christian Bode, Florian Kurth, Markus Ralser, Venizelos Papayannopoulos
Publikováno v:
Immunity.
The factors that influence survival during severe infection are unclear. Extracellular chromatin drives pathology, but the mechanisms enabling its accumulation remain elusive. Here, we show that in murine sepsis models, splenocyte death interferes wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb7c37ea9968e1b82df1092e391006b
https://pubmed.ncbi.nlm.nih.gov/36462503
https://pubmed.ncbi.nlm.nih.gov/36462503
Autor:
Iker Valle Aramburu, Dennis Hoving, Spyros I. Vernardis, Martha Tin, Vadim Demichev, Elisa Theresa Helbig, Lena Lippert, Klaus Stahl, Marianna Ioannou, Mia I. Temkin, Matthew White, Helena Radbruch, Jana Ihlow, David Horst, Scott T. Chiesa, John E. Deanfield, Sascha David, Christian Bode, Florian Kurth, Markus Ralser, Venizelos Papayannopoulos
SummaryHyperinflammation, coagulopathy and immune dysfunction are prominent in patients with severe infections. Extracellular chromatin clearance by plasma DNases suppresses such pathologies in mice but whether severe infection interferes with these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ad05c0917f5cc4186881d15f79f56d4
https://doi.org/10.1101/2022.01.25.22269616
https://doi.org/10.1101/2022.01.25.22269616
Autor:
Ziyue Wang, Adam Cryar, Oliver Lemke, Daniela Ludwig, Pinkus Tober-Lau, Elisa Theresa Helbig, Daniel Blake, Catherine S Lane, Rebekah L Sayers, Christoph Mueller, Johannes Zeiser, StJohn Townsend, Vadim Demichev, Michael Mülleder, Florian Kurth, Ernestas Sirka, Johannes Hartl, Markus Ralser
Global healthcare systems continue to be challenged by the COVID-19 pandemic, and there is a need for clinical assays that can both help to optimize resource allocation and accelerate the development and evaluation of new therapies. Here, we present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94f010939d836eabd11ba6e8b263ea0a
https://doi.org/10.1101/2021.12.03.21267253
https://doi.org/10.1101/2021.12.03.21267253
Autor:
Fridolin Steinbeis, Philipp Knape, Mirja Mittermaier, Elisa Theresa Helbig, Pinkus Tober-Lau, Charlotte Thibeault, Lena Johanna Lippert, Weiwei Xiang, Moritz Müller-Plathe, Sarah Steinbrecher, Hans-Jakob Meyer, Raphaela Maria Ring, Christoph Ruwwe-Glösenkamp, Florian Alius, Yaosi Li, Holger Müller-Redetzky, Alexander Uhrig, Tilman Lingscheid, Daniel Grund, Bettina Temmesfeld-Wollbrück, Norbert Suttorp, Leif Erik Sander, Florian Kurth, Martin Witzenrath, Thomas Zoller
Publikováno v:
Respiratory Medicine. 202:106968
Cardiopulmonary Exercise Testing (CPET) provides a comprehensive assessment of pulmonary, cardiovascular and musculosceletal function. Reduced CPET performance could be an indicator for chronic morbidity after COVID-19.Patients ≥18 years with confi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bd953908606574e039bb1ba0f7706b
https://doi.org/10.1016/j.rmed.2022.106968
https://doi.org/10.1016/j.rmed.2022.106968
Autor:
Philipp Georg, Rosario Astaburuaga-García, Lorenzo Bonaguro, Sophia Brumhard, Laura Michalick, Lena J. Lippert, Tomislav Kostevc, Christiane Gäbel, Maria Schneider, Mathias Streitz, Vadim Demichev, Ioanna Gemünd, Matthias Barone, Pinkus Tober-Lau, Elisa Theresa Helbig, Julia Stein, Hannah-Philine Dey, Daniela Paclik, Michael Mülleder, Simran Kaur Aulakh, Henrik E. Mei, Axel R. Schulz, Stefan Hippenstiel, Victor Max Corman, Dieter Beule, Emanuel Wyler, Markus Landthaler, Benedikt Obermayer-Wasserscheid, Peter Boor, Münevver Demir, Hans Wesselmann, Norbert Suttorp, Alexander Uhrig, Holger Müller-Redetzky, Jacob Nattermann, Wolfgang M. Kuebler, Christian Meisel, Markus Ralser, Joachim L. Schultze, Anna C. Aschenbrenner, Charlotte Thibeault, Florian Kurth, Leif-Erik Sander, Nils Blüthgen, Birgit Sawitzki
SummarySevere COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathogenesis, and it remains unclear if T cells also contribute to disease pathology. Here, we combined single-cell transcriptomics and proteomics with mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89aba5a5afc97e368ed42a3c27691dcb
https://doi.org/10.1101/2021.06.08.21258481
https://doi.org/10.1101/2021.06.08.21258481