Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Elisa Ten Hacken"'
Autor:
Elisa ten Hacken, Michaela Gruber, María Hernández-Sánchez, Gabriela Brunsting Hoffmann, Kaitlyn Baranowski, Robert A. Redd, Kendell Clement, Kenneth Livak, Catherine J. Wu
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102165- (2023)
Summary: Here, we present a protocol to generate B cell restricted mouse models of loss-of-function genetic drivers typical of lymphoproliferative disorders, using stem cell engineering of murine strains carrying B cell restricted Cas9 expression. We
Externí odkaz:
https://doaj.org/article/1aee18471536402abe13153e49a4c230
Autor:
Elisa ten Hacken, Kendell Clement, Shuqiang Li, María Hernández-Sánchez, Robert Redd, Shu Wang, David Ruff, Michaela Gruber, Kaitlyn Baranowski, Jose Jacob, James Flynn, Keith W. Jones, Donna Neuberg, Kenneth J. Livak, Luca Pinello, Catherine J. Wu
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-11 (2020)
Abstract CRISPR-Cas9 gene editing has transformed our ability to rapidly interrogate the functional impact of somatic mutations in human cancers. Droplet-based technology enables the analysis of Cas9-introduced gene edits in thousands of single cells
Externí odkaz:
https://doaj.org/article/0fc6668360f84aa68cc28a219254ce26
Autor:
Elisa ten Hacken, Maria Gounari, Jaap Willem Back, Ekaterina Shimanovskaya, Lydia Scarfò, Ekaterina Kim, Jared Burks, Maurilio Ponzoni, Giuseppe Alvise Ramirez, William G. Wierda, Zeev Estrov, Michael J. Keating, Alessandra Ferrajoli, Kostas Stamatopoulos, Paolo Ghia, Jan A. Burger
Publikováno v:
Haematologica, Vol 102, Iss 10 (2017)
Externí odkaz:
https://doaj.org/article/caa902b48d0449f0be21dcbfc63d6e4c
Autor:
Elisa ten Hacken, Tomasz Sewastianik, Shanye Yin, Gabriela Brunsting Hoffmann, Michaela Gruber, Kendell Clement, Livius Penter, Robert A. Redd, Neil Ruthen, Sébastien Hergalant, Alanna Sholokhova, Geoffrey Fell, Erin M. Parry, Julien Broséus, Romain Guieze, Fabienne Lucas, María Hernández-Sánchez, Kaitlyn Baranowski, Jackson Southard, Heather Joyal, Leah Billington, Fara Faye D. Regis, Elizabeth Witten, Mohamed Uduman, Binyamin A. Knisbacher, Shuqiang Li, Haoxiang Lyu, Tiziana Vaisitti, Silvia Deaglio, Giorgio Inghirami, Pierre Feugier, Stephan Stilgenbauer, Eugen Tausch, Matthew S. Davids, Gad Getz, Kenneth J. Livak, Ivana Bozic, Donna S. Neuberg, Ruben D. Carrasco, Catherine J. Wu
Publikováno v:
Blood Cancer Discovery. 4:150-169
Transformation to aggressive disease histologies generates formidable clinical challenges across cancers, but biological insights remain few. We modeled the genetic heterogeneity of chronic lymphocytic leukemia (CLL) through multiplexed in vivo CRISP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4ce5eeb848d6e6e0c825e20e21c87c
https://doi.org/10.1158/2643-3230.bcd-22-0082
https://doi.org/10.1158/2643-3230.bcd-22-0082
Autor:
Catherine J. Wu, Ruben D. Carrasco, Donna S. Neuberg, Ivana Bozic, Kenneth J. Livak, Gad Getz, Matthew S. Davids, Eugen Tausch, Stephan Stilgenbauer, Pierre Feugier, Giorgio Inghirami, Silvia Deaglio, Tiziana Vaisitti, Haoxiang Lyu, Shuqiang Li, Binyamin A. Knisbacher, Mohamed Uduman, Elizabeth Witten, Fara Faye D. Regis, Leah Billington, Heather Joyal, Jackson Southard, Kaitlyn Baranowski, María Hernández-Sánchez, Fabienne Lucas, Romain Guieze, Julien Broséus, Erin M. Parry, Geoffrey Fell, Alanna Sholokhova, Sébastien Hergalant, Neil Ruthen, Robert A. Redd, Livius Penter, Kendell Clement, Michaela Gruber, Gabriela Brunsting Hoffmann, Shanye Yin, Tomasz Sewastianik, Elisa ten Hacken
Transformation to aggressive disease histologies generates formidable clinical challenges across cancers, but biological insights remain few. We modeled the genetic heterogeneity of chronic lymphocytic leukemia (CLL) through multiplexed in vivo CRISP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148e97f2d0bfc152eeb638632ab1d55c
https://doi.org/10.1158/2643-3230.c.6551159
https://doi.org/10.1158/2643-3230.c.6551159
Autor:
Cox Terhorst, Pablo Engel, Roland W. Herzog, Jan A. Burger, Catherine J. Wu, Nicholas Chiorazzi, George C. Tsokos, Eri Katsuyama, Abel Suarez-Fueyo, Atul K. Bhan, Shih-Shih Chen, Elisa ten Hacken, Ninghai Wang, Burcu Yigit
Supplementary Tables and Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d275233ba6266701337d43419cf7458
https://doi.org/10.1158/2326-6066.22542312.v1
https://doi.org/10.1158/2326-6066.22542312.v1
Autor:
Catherine J. Wu, Ruben D. Carrasco, Donna S. Neuberg, Ivana Bozic, Kenneth J. Livak, Gad Getz, Matthew S. Davids, Eugen Tausch, Stephan Stilgenbauer, Pierre Feugier, Giorgio Inghirami, Silvia Deaglio, Tiziana Vaisitti, Haoxiang Lyu, Shuqiang Li, Binyamin A. Knisbacher, Mohamed Uduman, Elizabeth Witten, Fara Faye D. Regis, Leah Billington, Heather Joyal, Jackson Southard, Kaitlyn Baranowski, María Hernández-Sánchez, Fabienne Lucas, Romain Guieze, Julien Broséus, Erin M. Parry, Geoffrey Fell, Alanna Sholokhova, Sébastien Hergalant, Neil Ruthen, Robert A. Redd, Livius Penter, Kendell Clement, Michaela Gruber, Gabriela Brunsting Hoffmann, Shanye Yin, Tomasz Sewastianik, Elisa ten Hacken
Supplementary file contains a PDF version of supplementary figures S1-S7 and associated figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f43a2eb1f1900d44f00d9dd6804f444
https://doi.org/10.1158/2643-3230.22546355.v1
https://doi.org/10.1158/2643-3230.22546355.v1
Autor:
Cox Terhorst, Pablo Engel, Roland W. Herzog, Jan A. Burger, Catherine J. Wu, Nicholas Chiorazzi, George C. Tsokos, Eri Katsuyama, Abel Suarez-Fueyo, Atul K. Bhan, Shih-Shih Chen, Elisa ten Hacken, Ninghai Wang, Burcu Yigit
The tumor microenvironment in leukemia and solid tumors induces a shift of activated CD8+ cytotoxic T cells to an exhausted state, characterized by loss of proliferative capacity and impaired immunologic synapse formation. Efficient strategies and ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb55588ba67172e6c853ba3a42e4f79
https://doi.org/10.1158/2326-6066.c.6549870
https://doi.org/10.1158/2326-6066.c.6549870
Autor:
Catherine J. Wu, Ruben D. Carrasco, Donna S. Neuberg, Ivana Bozic, Kenneth J. Livak, Gad Getz, Matthew S. Davids, Eugen Tausch, Stephan Stilgenbauer, Pierre Feugier, Giorgio Inghirami, Silvia Deaglio, Tiziana Vaisitti, Haoxiang Lyu, Shuqiang Li, Binyamin A. Knisbacher, Mohamed Uduman, Elizabeth Witten, Fara Faye D. Regis, Leah Billington, Heather Joyal, Jackson Southard, Kaitlyn Baranowski, María Hernández-Sánchez, Fabienne Lucas, Romain Guieze, Julien Broséus, Erin M. Parry, Geoffrey Fell, Alanna Sholokhova, Sébastien Hergalant, Neil Ruthen, Robert A. Redd, Livius Penter, Kendell Clement, Michaela Gruber, Gabriela Brunsting Hoffmann, Shanye Yin, Tomasz Sewastianik, Elisa ten Hacken
Supplementary file contains all supplementary tables S1-S16 in Excel format in the order in which they appear in the text.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d0324c006cb0468af1370027af39a2
https://doi.org/10.1158/2643-3230.22546352.v1
https://doi.org/10.1158/2643-3230.22546352.v1
Autor:
Cox Terhorst, Pablo Engel, Roland W. Herzog, Jan A. Burger, Catherine J. Wu, Nicholas Chiorazzi, George C. Tsokos, Eri Katsuyama, Abel Suarez-Fueyo, Atul K. Bhan, Shih-Shih Chen, Elisa ten Hacken, Ninghai Wang, Burcu Yigit
Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11018acec9bb22afef36a4e8a9e3160d
https://doi.org/10.1158/2326-6066.22542315.v1
https://doi.org/10.1158/2326-6066.22542315.v1