Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Elisa S. Jansen"'
Autor:
Silvia A Fuertes Marraco, Clare L Scott, Philippe Bouillet, Annette Ives, Slavica Masina, David Vremec, Elisa S Jansen, Lorraine A O'Reilly, Pascal Schneider, Nicolas Fasel, Ken Shortman, Andreas Strasser, Hans Acha-Orbea
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20189 (2011)
BackgroundDC are activated by pathogen-associated molecular patterns (PAMPs), and this is pivotal for the induction of adaptive immune responses. Thereafter, the clearance of activated DC is crucial to prevent immune pathology. While PAMPs are of maj
Externí odkaz:
https://doaj.org/article/b56d3e79d01545d096a0a06502ed8744
Autor:
Mark S. Cragg, Gordon K. Smyth, Marco J Herold, Andreas Strasser, Clare L. Scott, Lina Happo, Cassandra J. Vandenberg, Elisa S. Jansen, Jon M. Haga, Grant Dewson, Belinda Phipson, Suzanne Cory, Ewa M. Michalak
Publikováno v:
Blood. 116:5256-5267
DNA-damaging chemotherapy is the backbone of cancer treatment, although it is not clear how such treatments kill tumor cells. In nontransformed lymphoid cells, the combined loss of 2 proapoptotic p53 target genes, Puma and Noxa, induces as much resis
Autor:
Andreas Strasser, Philippe Bouillet, David C.S. Huang, Elisa S. Jansen, Janette Allison, Thomas W.H. Kay, Helen E. Thomas, Mark D. McKenzie, Emma Jamieson, Clare L. Scott
Publikováno v:
Diabetes
OBJECTIVEHigh concentrations of circulating glucose are believed to contribute to defective insulin secretion and β-cell function in diabetes and at least some of this effect appears to be caused by glucose-induced β-cell apoptosis. In mammalian ce
Autor:
Clare L. Scott, Thomas W.H. Kay, Stacey Fynch, Andreas Strasser, Mark D. McKenzie, Elisa S. Jansen, Cameron Kos, Michelle Myers, Janette Allison, Emma M. Carrington
Publikováno v:
Diabetes
OBJECTIVEBcl-xL is an antiapoptotic member of the Bcl-2 family of proteins and a potent regulator of cell death. We investigated the importance of Bcl-xL for β-cells by deleting the Bcl-x gene specifically in β-cells and analyzing their survival in
Autor:
Mark S. Cragg, Claire L. Harris, Andreas Strasser, Elisa S. Jansen, Clare L. Scott, Michele Cook
Publikováno v:
Journal of Clinical Investigation. 118:3651-3659
B-RAF is frequently mutated in solid tumors, resulting in activation of the MEK/ERK signaling pathway and ultimately tumor cell growth and survival. MEK inhibition in these cells results in cell cycle arrest and cytostasis. Here, we have shown that M
Publikováno v:
Virus Research. 97:151-157
A recombinant porcine adenovirus expressing the classical swine fever virus (CSFV) gp55 gene (rPAdV-gp55) was administered to commercially available outbred pigs via the subcutaneous or oral route and their susceptibility to 'in contact' challenge wi
Autor:
C. J. Morrissy, Hooper Pt, Lorne A. Babiuk, Winsome V Goff, Jef M Hammond, Suresh K. Tikoo, Brenda van der Heide, M. M. Williamson, Elisa S Jansen, Michael A Johnson
Publikováno v:
Vaccine. 19:3752-3758
Five week old, commercially available large white pigs were vaccinated with either a single dose or two doses of a recombinant porcine adenovirus expressing the glycoprotein D gene from pseudorabies virus (PRV). Pigs were monitored for the developmen
Autor:
Elisa S Jansen, Michael A Johnson, Jef M Hammond, Barbara E.H. Coupar, M. M. Williamson, C. J. Morrissy, Greer Meehan, Kathy Sproat, Cor Lenghaus, Winsome V Goff, Marion E. Andrew
Publikováno v:
Veterinary Microbiology. 80:101-119
Weaned pigs (6-week-old) and 7-day-old pre-weaned piglets were vaccinated with naked plasmid DNA expressing the gp55/E2 gene from classical swine fever virus (CSFV). Both groups of pigs were then given a booster dose of recombinant porcine adenovirus
Autor:
Richard J McCoy, Adrian L. M. Hodgson, Elisa S Jansen, Jef M Hammond, Michael A Johnson, C. J. Morrissy
Publikováno v:
Vaccine. 18:1040-1050
A recombinant porcine adenovirus (rPAV) with the gp55 (E2) gene from the classical swine fever virus (CSFV) ‘Weybridge’ strain inserted into the right hand end of the PAV serotype 3 (PAV3) genome was constructed. Expression of gp55 was directed b
Publikováno v:
Methods (San Diego, Calif.). 61(2)
Mitochondria play a pivotal role in life and death of the cell because they produce the majority of energy required for survival and also regulate the intrinsic pathway to apoptosis. The involvement of mitochondria in cell death is generally measured