Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Elisa Pileggi"'
Autor:
Gaia Pasqualetto, Martin Schepelmann, Carmine Varricchio, Elisa Pileggi, Caroline Khogali, Siân R. Morgan, Ian Boostrom, Malgorzata Rozanowska, Andrea Brancale, Salvatore Ferla, Marcella Bassetto
Publikováno v:
Molecules, Vol 25, Iss 21, p 4904 (2020)
Accumulation of misfolded and mistrafficked rhodopsin on the endoplasmic reticulum of photoreceptor cells has a pivotal role in the pathogenesis of retinitis pigmentosa and a subset of Leber’s congenital amaurosis. One potential strategy to reduce
Externí odkaz:
https://doaj.org/article/1e783e04b31245e18c6cfa686b59132c
Autor:
David Dimmock, Patrick Crutcher, Margaret Beatka, Rebecca A. Slick, Jessica L. Sutton, Hui Meng, Michael W. Lawlor, Daniel Helbling, Mark A. Vanden Avond, Elisa Pileggi, Stephen Thomas, Fabrizio Pertusati, Michaela Serpi, Mariah J. Prom
Publikováno v:
Journal of inherited metabolic diseaseREFERENCES. 44(2)
Loss‐of‐function mutations in the deoxyguanosine kinase (DGUOK) gene result in a mitochondrial DNA (mtDNA) depletion syndrome. DGUOK plays an important role in converting deoxyribonucleosides to deoxyribonucleoside monophosphates via the salvage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf26e27b32b490df0dd15a454f8a350
https://pubmed.ncbi.nlm.nih.gov/33368311
https://pubmed.ncbi.nlm.nih.gov/33368311
Autor:
Dominique Schols, Elisa Pileggi, Robert Snoeck, Michaela Serpi, Graciela Andrei, Fabrizio Pertusati
Publikováno v:
Bioorganic & Medicinal Chemistry
Graphical abstract
The importance of phosphonoamidate prodrugs (ProTides) of acyclic nucleoside phosphonate (ANPs) is highlighted by the approval of Tenofovir Alafenamide Fumarate for the treatment of HIV and HBV infections. In the present paper
The importance of phosphonoamidate prodrugs (ProTides) of acyclic nucleoside phosphonate (ANPs) is highlighted by the approval of Tenofovir Alafenamide Fumarate for the treatment of HIV and HBV infections. In the present paper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb39e60e72bf163937d92e605376790f
https://doi.org/10.1016/j.bmc.2018.05.034
https://doi.org/10.1016/j.bmc.2018.05.034
Autor:
Elisa Pileggi, Carmine Varricchio, Malgorzata Barbara Rozanowska, Martin Schepelmann, Marcella Bassetto, Andrea Brancale, Gaia Pasqualetto
Publikováno v:
European Journal of Medicinal Chemistry. 226:113841
Inherited blinding diseases retinitis pigmentosa (RP) and a subset of Leber's congenital amaurosis (LCA) are caused by the misfolding and mistrafficking of rhodopsin molecules, which aggregate and accumulate in the endoplasmic reticulum (ER), leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26336925a9bec4b44050595a26c7e6d5
https://doi.org/10.1016/j.ejmech.2021.113841
https://doi.org/10.1016/j.ejmech.2021.113841
Autor:
Christopher McGuigan, Thijs Van Leemputte, Xabier Villanueva, Jennifer Richards, Mandy Wootton, Fabrizio Pertusati, Elisa Pileggi, Leentje Persoons, Michaela Serpi, Hans Steenackers, Dirk Daelemans, David De Coster
Publikováno v:
The Journal of antimicrobial chemotherapy. 75(10)
Objectives Following a drug repurposing approach, we aimed to investigate and compare the antibacterial and antibiofilm activities of different classes of phosphate prodrugs (HepDirect, cycloSal, SATE and mix SATE) of antiviral and anticancer FDA-app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429b4ac9f796cf6c19f0809a77f02bab
https://pubmed.ncbi.nlm.nih.gov/32688391
https://pubmed.ncbi.nlm.nih.gov/32688391
Autor:
Kuo-Shyan Lin, Sergii Afonin, Justin J. Bailey, Pablo Barrio, Francois Benard, Vadim Bernard-Gauthier, Thierry Billard, Silvestre Buscemi, Fabien Caillé, Loïc P. Chêne, Julien A. Delbrouck, Kevin D. Dykstra, Myriem El Qacemi, Lori Fitz, Santos Fustero, Jéôme Graton, Oliver Gutbrod, Tadashi Honda, Luke Hunter, Naoko Ichiishi, Peter Jeschke, Klaus Jurkschat, Igor V. Komarov, Olga Koshkina, Shane W. Krska, Bertrand Kuhnast, Jean-Yves Le Questel, Frederic R. Leroux, François Liger, Bruno Linclau, Peter Maienfisch, Flora Mansour, Klaus Müller, Cormac D. Murphy, Iwao Ojima, Andrea Pace, William Palmer-Brown, Antonio Palumbo Piccionello, David M. Perrin, Fabrizio Pertusati, Ivana Pibiri, Elisa Pileggi, Laura Quinn, Stefano Rendine, Paul F. Richardson, Mélanie Roche, Raquel Román, Marta Saccomanno, Ralf Schirrmacher, Esther Schirrmacher, Daniel M. Sedgwick, Michaela Serpi, Simon Specklin, Mangala Srinivas, Xander Staal, Andrés A. Trabanco, Anne S. Ulrich, Mathieu Verdurand, Stéphane P. Vincent, Carmen Wängler, Björn Wängler, Li Xing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68e6cf90fd569787b54636f8c72764fe
https://doi.org/10.1016/b978-0-12-812733-9.01002-3
https://doi.org/10.1016/b978-0-12-812733-9.01002-3
The introduction of fluorine in drug-like compounds is now a well-accepted and very efficient strategy in drug discovery, encouraged by the extensive synthetic methodologies available. Nowadays, not only fluorine but polyfluorinated groups such as tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20a1a1c8eb830639d56bdde0152d064e
https://doi.org/10.1016/b978-0-12-812733-9.00003-9
https://doi.org/10.1016/b978-0-12-812733-9.00003-9
Publikováno v:
Current protocols in nucleic acid chemistry. 74(1)
This synthetic protocol describes two strategies for the preparation of pyrimidine alkenyl acyclic nucleoside phosphonoamidates (ANPs), including linear and trisubstituted alkenyl derivatives. For the first procedure, a bis-trimethylsilyl ester of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2432fa5501a95f1c9afc5fdd949da4
https://pubmed.ncbi.nlm.nih.gov/30102460
https://pubmed.ncbi.nlm.nih.gov/30102460