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pro vyhledávání: '"Elisa Piccioni"'
TNF-α-Secreting Lung Tumor-Infiltrated Monocytes Play a Pivotal Role During Anti-PD-L1 Immunotherapy
Autor:
Kirsten De Ridder, Hanne Locy, Elisa Piccioni, Miren Ibarra Zuazo, Robin Maximilian Awad, Stefaan Verhulst, Mathias Van Bulck, Yannick De Vlaeminck, Quentin Lecocq, Eva Reijmen, Wout De Mey, Lien De Beck, Thomas Ertveldt, Isabel Pintelon, Jean-Pierre Timmermans, David Escors, Marleen Keyaerts, Karine Breckpot, Cleo Goyvaerts
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immune checkpoint blockade (ICB) of the PD-1 pathway revolutionized the survival forecast for advanced non-small cell lung cancer (NSCLC). Yet, the majority of PD-L1+ NSCLC patients are refractory to anti-PD-L1 therapy. Recent observations indicate a
Externí odkaz:
https://doaj.org/article/8cb0f64de304414d9efd07fa0701e7a3
Autor:
Kirsten De Ridder, Hanne Locy, Elisa Piccioni, Miren Ibarra Zuazo, Robin Maximilian Awad, Stefaan Verhulst, Mathias Van Bulck, Yannick De Vlaeminck, Quentin Lecocq, Eva Reijmen, Wout De Mey, Lien De Beck, Thomas Ertveldt, Isabel Pintelon, Jean-Pierre Timmermans, David Escors, Marleen Keyaerts, Karine Breckpot, Cleo Goyvaerts
Publikováno v:
Frontiers in immunology
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname
Immune checkpoint blockade (ICB) of the PD-1 pathway revolutionized the survival forecast for advanced non-small cell lung cancer (NSCLC). Yet, the majority of PD-L1+ NSCLC patients are refractory to anti-PD-L1 therapy. Recent observations indicate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637189a9817d5664fb7792a00077d19e
https://hdl.handle.net/2454/43383
https://hdl.handle.net/2454/43383
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8691, p 8691 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Tumor necrosis factor-alpha (TNFα) can bind two distinct receptors (TNFR1/2). The transmembrane form (tmTNFα) preferentially binds to TNFR2. Upon tmTNFα cleavage by the TNF-alpha-converting enzyme (TACE), its soluble (sTNFα) form is released with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cc2d4d3a3a45c87aabe3c8d0493e49
https://hdl.handle.net/20.500.14017/7b835de3-ea29-4c95-9795-5d44bb651b79
https://hdl.handle.net/20.500.14017/7b835de3-ea29-4c95-9795-5d44bb651b79