Insights into the mechanisms of interaction between inhalable lipid-polymer hybrid nanoparticles and pulmonary surfactant

Autor: You Xu, Elisa Parra-Ortiz, Feng Wan, Olga Cañadas, Begoña Garcia-Alvarez, Aneesh Thakur, Henrik Franzyk, Jesús Pérez-Gil, Martin Malmsten, Camilla Foged

Publikováno v: Xu, Y, Parra-Ortiz, E, Wan, F, Cañadas, O, Garcia-Alvarez, B, Thakur, A, Franzyk, H, Pérez-Gil, J, Malmsten, M & Foged, C 2023, ' Insights into the mechanisms of interaction between inhalable lipid-polymer hybrid nanoparticles and pulmonary surfactant ', Journal of Colloid and Interface Science, vol. 633, pp. 511-525 . https://doi.org/10.1016/j.jcis.2022.11.059

Pulmonary delivery of small interfering RNA (siRNA) using nanoparticle-based delivery systems is promising for local treatment of respiratory diseases. We designed dry powder inhaler formulations of siRNA-loaded lipid-polymer hybrid nanoparticles (LP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23d687a5497c7778f2c5af3575adf93
https://doi.org/10.1016/j.jcis.2022.11.059

Surface-functionalized polystyrene nanoparticles alter the transmembrane potential via ion-selective pores maintaining global bilayer integrity

Autor: Antonio Alcaraz, Deborah Aurora Perini, Martin Malmsten, Inmaculada Varó, Elisa Parra-Ortiz, María Queralt-Martín

Publikováno v: Langmuir: the ACS journal of surfaces and colloids.

Although nanoplastics have well-known toxic effects toward the environment and living organisms, their molecular toxicity mechanisms, including the nature of nanoparticle–cell membrane interactions, are still under investigation. Here, we employ dy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae9574dcfc6afb9395aad642f47ba0d
http://hdl.handle.net/10261/303726

Pulmonary surfactant and drug delivery: Vehiculization of a tryptophan-tagged antimicrobial peptide over the air-liquid interfacial highway

Autor: Cristina García-Mouton, Elisa Parra-Ortiz, Martin Malmsten, Antonio Cruz, Jesús Pérez-Gil

Publikováno v: E-Prints Complutense. Archivo Institucional de la UCM
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García-Mouton, C, Parra-Ortiz, E, Malmsten, M, Cruz, A & Pérez-Gil, J 2022, ' Pulmonary surfactant and drug delivery : Vehiculization of a tryptophan-tagged antimicrobial peptide over the air-liquid interfacial highway ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 180, pp. 33-47 . https://doi.org/10.1016/j.ejpb.2022.09.018

This work evaluates interaction of pulmonary surfactant (PS) and antimicrobial peptides (AMPs) in order to investigate (i) if PS can be used to transport AMPs, and (ii) to what extent PS interferes with AMP function and vice versa. This, in turn, is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0acab17e6d0900bbf1e161c1e5c9bd
https://pubmed.ncbi.nlm.nih.gov/36154903

Interaction of polystyrene nanoparticles with phospholipid membranes induces ion channel-like activity

Autor: Deborah Aurora Perini, Elisa Parra-Ortiz, Inmaculada Varó, Maria Queralt-Martin, Martin Malmsten, Antonio Alcaraz

Publikováno v: Biophysical Journal. 121:483a

Trabajo presentado en el BPS2022: 66th Biophysical Society Annual Meeting, celebrado en San Francisco, California (Estados Unidos), del 19 al 23 de febrero de 2022.
Polystyrene nanoparticles can be chemically synthetized at will or naturally pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144748720a902b0a36cda3f9add9135e
https://doi.org/10.1016/j.bpj.2021.11.361

Towards the Molecular Mechanism of Pulmonary Surfactant Protein SP-B: At the Crossroad of Membrane Permeability and Interfacial Lipid Transfer

Autor: Marta Martínez-Calle, Jesús Pérez-Gil, Elisa Parra-Ortiz, Antonio Cruz, Bárbara Olmeda

Publikováno v: Journal of Molecular Biology. 433:166749

Pulmonary surfactant is a lipid-protein complex that coats the alveolar air-liquid interface, enabling the proper functioning of lung mechanics. The hydrophobic surfactant protein SP-B, in particular, plays an indispensable role in promoting the rapi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441b29a6af3891b02005e2d006c21bd4
https://doi.org/10.1016/j.jmb.2020.166749