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Akademický článek

Asymmetric neurogenic commitment of retinal progenitors involves Notch through the endocytic pathway

Autor: Elisa Nerli, Mauricio Rocha-Martins, Caren Norden

Publikováno v: eLife, Vol 9 (2020)

During brain development, progenitor cells need to balanceproliferation and differentiation in order to generate different neurons in the correct numbers and proportions. Currently, the patterns of multipotent progenitor divisions that lead to neurog

Externí odkaz: https://doaj.org/article/a8aeb3f98235463d9dbed438a01236cf

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Deterministic and probabilistic fate decisions co‐exist in a single retinal lineage

Autor: Elisa Nerli, Jenny Kretzschmar, Tommaso Bianucci, Mauricio Rocha‐Martins, Christoph Zechner, Caren Norden

Publikováno v: The EMBO Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3ca2420a30f1203889f6bbc8434a157
https://doi.org/10.15252/embj.2022112657

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Deterministic and probabilistic fate decisions co-exist in a single retinal lineage

Autor: Caren Norden, Christoph Zechner, Elisa Nerli, Tommaso Bianucci, Jenny Kretzschmar, Maurício Rocha-Martins

SummaryCorrect nervous system development depends on the timely differentiation of progenitor cells into neurons. While the output of progenitor differentiation is well investigated at the population and clonal level, the possibilities and constraint

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d0c5c201f3f176f0fba5b66bed38e91
https://doi.org/10.1101/2022.08.11.503564

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Stochasticity and determinism in cell fate decisions

Autor: Christoph Zechner, Elisa Nerli, Caren Norden

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Development

During development, cells need to make decisions about their fate in order to ensure that the correct numbers and types of cells are established at the correct time and place in the embryo. Such cell fate decisions are often classified as determinist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7414afcd37470c37639b0568af413b02

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Asymmetric neurogenic commitment of retinal progenitors is regulated via the Notch endocytic pathway

Autor: Caren Norden, Elisa Nerli, Mauricio Rocha-Martins

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

During brain development, progenitor cells need to balance proliferation and differentiation in order to generate different neurons in the correct numbers and proportions. Currently, the patterns of multipotent progenitors’ division that lead to ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e32bdf252fed3d5e8876f44eb81851
https://hdl.handle.net/10400.7/960

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In vitro modeling of dendritic atrophy in Rett syndrome: determinants for phenotypic drug screening in neurodevelopmental disorders

Autor: Enrico Tongiorgi, Gabriele Baj, Ottavia Maria Roggero, Elisa Nerli

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports

Dendritic atrophy, defined as the reduction in complexity of the neuronal arborization, is a hallmark of several neurodevelopmental disorders, including Rett Syndrome (RTT). RTT, affecting 1:10,000 girls worldwide, is mainly caused by mutations in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffd6dd83ed6312ecd2ecbc9481abfe2
https://hdl.handle.net/11368/2998773

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