Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition

Autor: Davide Capelli, Giulia Cazzaniga, Matteo Mori, Antonio Laghezza, Fulvio Loiodice, Martina Quaglia, Elisa Negro, Fiorella Meneghetti, Stefania Villa, Roberta Montanari

Publikováno v: Biomolecules, Vol 13, Iss 4, p 694 (2023)

PPARγ represents a key target for the treatment of type 2 diabetes and metabolic syndrome. To avoid serious adverse effects related to the PPARγ agonism profile of traditional antidiabetic drugs, a new opportunity is represented by the development

Externí odkaz: https://doaj.org/article/48a2d402920e430a9dc364be84f2f22f

Different outcomes of endurance and resistance exercise in skeletal muscles of Oculopharyngeal muscular dystrophy

Autor: Alexis Boulinguiez, Jamila Dhiab, Barbara Crisol, Laura Muraine, Ludovic Gaut, Corentin Rouxel, Justine Flaire, Hadidja‐Rose Mouigni, Mégane Lemaitre, Benoit Giroux, Lucie Audoux, Benjamin SaintPierre, Arnaud Ferry, Vincent Mouly, Gillian Butler‐Browne, Elisa Negroni, Alberto Malerba, Capucine Trollet

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 5, Pp 1976-1988 (2024)

Abstract Background Exercise is widely considered to have beneficial impact on skeletal muscle aging. In addition, there are also several studies demonstrating a positive effect of exercise on muscular dystrophies. Oculopharyngeal muscular dystrophy

Externí odkaz: https://doaj.org/article/9e6f075692794eb9b63cdf6993ff5f94

The potential use of tetracyclines in neurodegenerative diseases and the role of nano-based drug delivery systems

Autor: Mahdieh Rahmani, Sofía Elisa Negro Álvarez, Emilia Barcia Hernández

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 175

Neurodegenerative diseases are still a challenge for effective treatments. The high cost of approved drugs, severity of side effects, injection site pain, and restrictions on drug delivery to the Central Nervous System (CNS) can overshadow the manage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed7ddb391851b0bb9c1290516dff156
https://pubmed.ncbi.nlm.nih.gov/35710076

A negative feedback loop between fibroadipogenic progenitors and muscle fibres involving endothelin promotes human muscle fibrosis

Autor: Mona Bensalah, Laura Muraine, Alexis Boulinguiez, Lorenzo Giordani, Victorine Albert, Victor Ythier, Jamila Dhiab, Alison Oliver, Valentine Hanique, Teresa Gidaro, Sophie Perié, Jean Lacau St‐Guily, Aurélien Corneau, Gillian Butler‐Browne, Anne Bigot, Vincent Mouly, Elisa Negroni, Capucine Trollet

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 3, Pp 1771-1784 (2022)

Abstract Background Fibrosis is defined as an excessive accumulation of extracellular matrix (ECM) components. Many organs are subjected to fibrosis including the lung, liver, heart, skin, kidney, and muscle. Muscle fibrosis occurs in response to tra

Externí odkaz: https://doaj.org/article/7c62485f71544d54a83dad75fc3fe420

Neurofunctional signature of hyperfamiliarity for unknown faces

Autor: Alessia Celeghin, Paola Caroppo, Lorenzo Pinessi, F. Ferrio, Marco Tamietto, Innocenzo Rainero, Elisa Negro, Matteo Diano, Elisa Rubino, Federico D'Agata, Beatrice de Gelder, Mario Gino Coriasco

Publikováno v: PLOS ONE, 10(7):e0129970. Public Library of Science
PLoS ONE, Vol 10, Iss 7, p e0129970 (2015)
PLOS ONE, 10(7):e0129970. PUBLIC LIBRARY SCIENCE
PLoS ONE

Hyperfamiliarity for unknown faces is a rare selective disorder that consists of the disturbing and abnormal feeling of familiarity for unknown faces, while recognition of known faces is normal. In one such patient we investigated with a multimodal n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ed29c37f5be0477c2f6aa1aff21fd2
https://research.tilburguniversity.edu/en/publications/fd355e75-82d0-4e52-bd59-601fb49dde4c