More than meets the eye: The role of microglia in healthy and diseased retina

Autor: Elisa Murenu, Maximilian-Joachim Gerhardt, Martin Biel, Stylianos Michalakis

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Microglia are the main resident immune cells of the nervous system and as such they are involved in multiple roles ranging from tissue homeostasis to response to insults and circuit refinement. While most knowledge about microglia comes from brain st

Externí odkaz: https://doaj.org/article/d70db39d90da4162bb2681ff372ce53c

A universal protocol for isolating retinal ON bipolar cells across species via fluorescence-activated cell sorting

Autor: Dirk Grimm, Jasmina Cehajic-Kapetanovic, Andrew Hayes, Robert J. Lucas, Marina Pavlou, Rachel Scholey, Hildegard Büning, Elisa Murenu, Neda Tafrishi, Stylianos Michalakis, Sabrina Just, Lisa Richter, Kleopatra Rapti

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 587-600 (2021)
Molecular Therapy. Methods & Clinical Development

Inherited retinal dystrophies (IRDs) are characterized by progressive degeneration and loss of light-sensing photoreceptors. The most promising therapeutic approach for IRDs is gene supplementation therapy using viral vectors, which requires the pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2cb0f91278ca8987de3b6962508214c
https://doi.org/10.1016/j.omtm.2021.01.011

Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice

Autor: Axel Imhof, Stylianos Michalakis, Shibojyoti Lahiri, Elisa Murenu, Anna S. Geserich, Sarantos Kostidis, Martin Giera

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 5
International Journal of Molecular Sciences, 22(5). MDPI
International Journal of Molecular Sciences, Vol 22, Iss 2345, p 2345 (2021)

Photoreceptors are the light-sensing cells of the retina and the major cell type affected in most inherited retinal degenerations. Different metabolic pathways sustain their high energetic demand in physiological conditions, particularly aerobic glyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf7e4c02778882e6132a39e5111ff17

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

Autor: Susan Gascon, Magdalena Götz, Martin Irmler, Felipe Ortega, David Petrik, Stephen P. Robertson, Johannes Beckers, Gianluca Luigi Russo, Aditi Deshpande, Marisa Karow, Carsten Berndt, Marcus Conrad, Giacomo Masserdotti, Timm Schroeder, Benedikt Berninger, José Pedro Friedmann Angeli, Christophe Heinrich, Elisa Murenu

Publikováno v: Cell Stem Cell 18, 396-409 (2016)

Despite the widespread interest in direct neuronal reprogramming, the mechanisms underpinning fate conversion remain largely unknown. Our study revealed a critical time point after which cells either successfully convert into neurons or succumb to ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f90d111a76cdde4abcc3d061f10de0f
https://doi.org/10.1016/j.stem.2015.12.003

Stem Cells and the Retina – Challenges for Regenerative Medicine

Autor: Elisa Murenu, Simona Casarosa, Andrea Messina

Publikováno v: Embryonic Stem Cells-Recent Advances in Pluripotent Stem Cell-Based Regenerative Medicine

The retina, as one of the most accessible parts of the nervous system, has been extensively studied in different animal models. These studies have highlighted a remarkable conservation of the molecular mechanisms and gene regulatory networks involved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958bab59fcfb55b06dccb0764d62c5e7
https://doi.org/10.5772/14780