Albumin Redox Modifications Promote Cell Calcification Reflecting the Impact of Oxidative Status on Aortic Valve Disease and Atherosclerosis

Autor: Tamara Sastre-Oliva, Nerea Corbacho-Alonso, Elena Rodriguez-Sanchez, Elisa Mercado-García, Ines Perales-Sanchez, German Hernandez-Fernandez, Cristina Juarez-Alia, Teresa Tejerina, Luis F. López-Almodóvar, Luis R. Padial, Pedro L. Sánchez, Ernesto Martín-Núñez, Natalia López-Andrés, Gema Ruiz-Hurtado, Laura Mourino-Alvarez, Maria G. Barderas

Publikováno v: Antioxidants, Vol 13, Iss 1, p 108 (2024)

Calcific aortic valve disease (CAVD) and coronary artery disease (CAD) are related cardiovascular diseases in which common mechanisms lead to tissue calcification. Oxidative stress plays a key role in these diseases and there is also evidence that th

Externí odkaz: https://doaj.org/article/6e7cdbee88f146f494f7064ff564f8f7

Partial Genetic Deletion of Klotho Aggravates Cardiac Calcium Mishandling in Acute Kidney Injury

Autor: Laura González-Lafuente, José Alberto Navarro-García, Ángela Valero-Almazán, Elena Rodríguez-Sánchez, Sara Vázquez-Sánchez, Elisa Mercado-García, Patricia Pineros, Jonay Poveda, María Fernández-Velasco, Makoto Kuro-O, Luis M. Ruilope, Gema Ruiz-Hurtado

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 2, p 1322 (2023)

Acute kidney injury (AKI) is associated with an elevated risk of cardiovascular major events and mortality. The pathophysiological mechanisms underlying the complex cardiorenal network interaction remain unresolved. It is known that the presence of A

Externí odkaz: https://doaj.org/article/6869b39e948f406b864bc9d8640b2cd2

Interplay between mineral bone disorder and cardiac damage in acute kidney injury: from Ca 2+ mishandling and preventive role of Klotho in mice to its potential mortality prediction in human

Autor: LAURA GONZÁLEZ-LAFUENTE, JOSÉ ALBERTO NAVARRO-GARCÍA, ELENA RODRÍGUEZ-SÁNCHEZ, JENNIFER ACEVES-RIPOLL, JONAY POVEDA, SARA VÁZQUEZ-SÁNCHEZ, ELISA MERCADO-GARCÍA, MARÍA FERNÁNDEZ-VELASCO, MAKOTO KURO-O, FERNANDO LIAÑO, LUIS M. RUILOPE, GEMA RUIZ-HURTADO

Biomarkers of mineral bone disorders (MBD) including phosphorus, fibroblast growth factor (FGF)-23 and Klotho are strongly altered in patients with acute kidney injury (AKI) who have high cardiac outcomes and mortality rates. However, the crosslink b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7220327c2480e6c9c4542171e71543
https://hdl.handle.net/11268/11150

Oxidized Low-Density Lipoprotein Associates with Ventricular Stress in Young Adults and Triggers Intracellular Ca2+ Alterations in Adult Ventricular Cardiomyocytes

Autor: Gema Ruiz-Hurtado, Elena Rodríguez-Sánchez, Maria G. Barderas, Nerea Corbacho-Alonso, Jennifer Aceves-Ripoll, Sara Vázquez-Sánchez, Eva Calvo-Bonacho, José Alberto Navarro-García, Luis M. Ruilope, Laura González-Lafuente, Elisa Mercado-García, María Fernández-Velasco, Jonay Poveda, Gloria Alvarez-Llamas

Publikováno v: Antioxidants, Vol 9, Iss 1213, p 1213 (2020)
Antioxidants
Volume 9
Issue 12
ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)

Oxidized low-density lipoprotein (oxLDL) is associated with cardiac damage and causes injury to multiple cell types. We aimed to investigate the role of oxLDL in ventricular stress. We first examined the association between circulating oxLDL and N-te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256791c5153e363556bb28d8da8cadce
https://doi.org/10.3390/antiox9121213